@article{Gorlova2026,

title = {Partial Serotonin Transporter Deficiency Modulates Plasma Metabolome, Arginine-Nitric Oxide Pathway and Emotional Behavior in Mice Exposed to Western Diet},

author = {Anna Gorlova and Raymond Cespuglio and Angelika Schmitt-Böhrer and Alexey Deykin and Allan V. Kalueff and Ksenia Lebedeva and Andrey Nedorubov and Gabriela Ortega Shulte and Evgeniy Svirin and Aleksey Lyundup and Klaus-Peter Lesch and Tatyana Strekalova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3390_metabo16020117.pdf},

doi = {10.3390/metabo16020117},

issn = {2218-1989},

year  = {2026},

date = {2026-02-06},

urldate = {2026-02-00},

journal = {Metabolites},

volume = {16},

number = {2},

publisher = {MDPI AG},

abstract = {Reduced serotonin transporter (SERT) function is associated with increased vulnerability to emotional and metabolic dysregulation, particularly in elderly women. Most preclinical studies relied on young male rodents with complete Sert deficiency; the Western diet (WD) acerbates these abnormalities. However, complete Sert loss does not fully reflect the human condition of partial SERT dysfunction. Here, we examined the effects of WD in aged female Sert+/− mice on metabolic, biochemical, molecular, and behavioral outcomes. Methods: Wild-type (WT) and Sert+/− mice were fed WD or a control diet. Emotionality, cognition, glucose tolerance (GT), plasma 1HNMR spectroscopy metabolome and biochemical parameters were studied. Gene expression analyses of nitric oxide (NO)-related markers were performed in the hypothalamus, dorsal raphe, and liver. Results: WD-exposed WT mice showed impaired GT and reduced plasma lactate and branched-chain amino acid levels; metabolome changes were more pronounced in mutants, while GT was unchanged. Naïve Sert+/− mice exhibited lower lactate and alanine levels compared with WT controls. WD increased leptin and cholesterol levels in both genotypes, whereas triglyceride concentrations were reduced in Sert+/− mice. Both WD and Sert deficiency increased Nos expression, while arginase expression was differentially regulated by genotype and diet. Malondialdehyde levels were elevated in the prefrontal cortex of Sert+/− mice regardless diet. WD also impaired object recognition memory and induced anxiety- and depression-like behaviors, with more pronounced effects in Sert+/− mice, except marble test behavior. Conclusions: Partial Sert deficiency aggravates some but not all WD-induced metabolic alterations, enhances oxidative stress, dysregulates arginine–NO signaling, and modifies behavior, highlighting the translational relevance of Sert+/− mice for modeling SERT dysfunction.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vasilyev2025,

title = {Intentionally versus spontaneously prolonged Gaze: A MEG study of active gaze-based interaction},

author = {Anatoly N. Vasilyev and Evgeniy P. Svirin and Ignat A. Dubynin and Anna V. Butorina and Yuri O. Nuzhdin and Alexei E. Ossadtchi and Tatiana A. Stroganova and Sergei L. Shishkin},

url = {https://www.biorxiv.org/content/10.1101/2024.12.11.627776v1.full.pdf},

doi = {10.1016/j.cortex.2025.05.010},

issn = {0010-9452},

year  = {2025},

date = {2025-08-00},

urldate = {2025-08-00},

journal = {Cortex},

volume = {189},

pages = {76-96},

publisher = {Elsevier BV},

abstract = {Eye fixations are increasingly employed to control computers through gaze-sensitive interfaces, yet the brain mechanisms supporting this non-visual use of gaze remain poorly understood. In this study, we employed 306-channel magnetoencephalography (MEG) to find out what is specific to brain activity when gaze is used voluntarily for control.

MEG was recorded while participants played a video game controlled by their eye movements. Each move required object selection by fixating it for at least 500 msec. Gaze dwells were classified as intentional if followed by a confirmation gaze on a designated location and as spontaneous otherwise.

We identified both induced oscillatory and sustained phase-locked MEG activity differentiating intentional and spontaneous gaze dwells. Induced power analysis revealed prominent alpha-beta band synchronization (8–30 Hz) localized in the frontal cortex, with location broadly consistent with the frontal eye fields. This synchronization began 500–750 msec before intentional fixation onset and peaked shortly after it, suggesting proactive inhibition of saccadic activity. Sustained evoked responses further distinguished the two conditions, showing gradually rising cortical activation with a maximum at 200 msec post-onset in the inferior temporal cortex during intentional fixations, likely indicative of focused attentional engagement on spatial targets. These findings illuminate the neural dynamics underlying intentional gaze control, shedding light on the roles of proactive inhibitory mechanisms and attentional processes in voluntary behavior.

By leveraging a naturalistic gaze-based interaction paradigm, this study offers a novel framework for investigating voluntary control under free behavior conditions and holds potential applications for enhancing hybrid eye-brain-computer interfaces.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}