@article{Гояева2024,

title = {Специфика оценивания фонематического слуха и его особенностей у детей с РАС},

author = {Д.Э. Гояева and Т.С. Обухова and Т.М. Овсянникова and А.М. Рытикова and Ц.Г. Джиоева and А. Павлова and А.Ю. Николаева},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.51217_npsyresearch_2024_04_01_07.pdf},

doi = {10.51217/npsyresearch_2024_04_01_07},

issn = {2782-2184},

year  = {2024},

date = {2024-04-03},

urldate = {2024-04-03},

journal = {Новые Психологические Исследования},

volume = {4},

number = {1},

pages = {143-158},

publisher = {Московский институт психоанализа},

abstract = {Расстройства аутистического спектра (РАС) характеризуются широким диапазоном когнитивных, социальных и коммуникативных нарушений. Одним из наиболее заметных проявлений РАС являются трудности в области речи и языка, которые могут серьезно ограничивать способность индивидов с РАС к эффективному общению и взаимодействию с окружающим миром. Проблема диагностики речевых нарушений у лиц с РАС усложняется тем, что многие существующие методики оценки не позволяют четко разделить речевые и языковые трудности от общего уровня интеллектуального развития, что может приводить к неточностям в интерпретации результатов. В данной работе мы сосредоточились на выявлении тех аспектов фонематического восприятия, которые могут быть оценены с минимальным влиянием интеллектуальных факторов. Для этого были использованы фонематические субтесты из комплексной диагностической батареи «КОРАБЛИК». Мы тщательно проанализировали результаты выполнения таких заданий, как «Повторение слов», «Повторение псевдослов», «Понимание существительных» и «Понимание глаголов», чтобы определить их способность отражать специфические речевые нарушения у детей с РАС. Результаты анализа показали наличие дефицита фонематического восприятия у детей с РАС, однако только результат задания «Повторение псевдослов» продемонстрировал стабильную корреляцию с речевыми нарушениями, не зависимо от уровня интеллекта участников. Данные результаты подчеркивают критическую необходимость в разработке и адаптации специализированных диагностических инструментов, которые были бы чувствительны к специфике речевых и языковых нарушений у лиц с РАС, но в то же время минимально зависели от их когнитивных способностей. Такие инструменты могли бы значительно улучшить точность диагностики и, как следствие, эффективность последующих коррекционных и образовательных программ для детей с РАС.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Goyaeva2023b,

title = {Особенности фонематического восприятия речи у обучающихся с билингвизмом},

author = {Гояева, Д.Э. and Обухова, Т.С. and Овсянникова, Т.М. and Рытикова, А.М. and Павлова, А.А. and Джиоева, Ц.Г. and Кокоев, Т.И. and Николаева, А.Ю.},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.17759_exppsy.2023160409.pdf},

doi = {10.17759/exppsy.2023160409},

issn = {2311-7036},

year  = {2023},

date = {2023-12-01},

urldate = {2023-12-01},

journal = {Экспериментальная психология},

volume = {16},

number = {4},

pages = {129-142},

publisher = {Московский государственный психолого-педагогический университет},

abstract = {В Российской Федерации используется, по разным источникам, от 277 до 295 различных языков, что делает очень важным вопрос оценки влияния билингвизма на восприятие речи, например в контексте школьного обучения. Существуют противоречивые данные о том, как дети, растущие в двуязычной среде, распознают отдельные фонемы. В данной работе мы сравнили восприятие фонем русского языка на слух у детей младшего и среднего школьного возраста из моноязычной (русскоязычной) и двуязычной (русскоязычной и осетиноязычной) среды при помощи речевого теста «КОРАБЛИК» («Клиническая оценка развития базовых лингвистических компетенций») и психофизической задачи на различение слов в шуме. Было обнаружено, что двуязычные дети хуже повторяют псевдослова и распознают фонемы в стационарном шуме, что говорит о наличии значимых затруднений, но проявляющихся только в ситуациях нового/затрудненного восприятия. Причины затруднений могут быть связаны с тем, что у детей, растущих в двуязычной среде, значительно шире перечень фонем, которые необходимо распознавать, чем у детей, растущих в моноязычной среде. Это может приводить к сниженному распознаванию речи на языке обучения и, соответственно, возможному снижению качества обучения.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pavlova2023,

title = {Learning of new associations invokes a major change in modulations of cortical beta oscillations in human adults},

author = {Anna Pavlova and Nikita Tyulenev and Vera Tretyakova and Valeriya Skavronskaya and Anastasia Nikolaeva and Andrey Prokofyev and Tatiana Stroganova and Boris Chernyshev},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1111_psyp.14284.pdf},

doi = {10.1111/psyp.14284},

issn = {1469-8986},

year  = {2023},

date = {2023-08-00},

urldate = {2023-08-00},

journal = {Psychophysiology},

volume = {60},

issue = {8},

pages = {e14284},

publisher = {Wiley},

abstract = {Large-scale cortical beta (β) oscillations were implicated in the learning processes, but their exact role is debated. We used MEG to explore the dynamics of movement-related β-oscillations while 22 adults learned, through trial and error, novel associations between four auditory pseudowords and movements of four limbs. As learning proceeded, spatial–temporal characteristics of β-oscillations accompanying cue-triggered movements underwent a major transition. Early in learning, widespread suppression of β-power occurred long before movement initiation and sustained throughout the whole behavioral trial. When learning advanced and performance reached asymptote, β-suppression after the initiation of correct motor response was replaced by a rise in β-power mainly in the prefrontal and medial temporal regions of the left hemisphere. This post-decision β-power predicted trial-by-trial response times (RT) at both stages of learning (before and after the rules become familiar), but with different signs of interaction. When a subject just started to acquire associative rules and gradually improved task performance, a decrease in RT correlated with the increase in the post-decision β-band power. When the participants implemented the already acquired rules, faster (more confident) responses were associated with the weaker post-decision β-band synchronization. Our findings suggest that maximal beta activity is pertinent to a distinct stage of learning and may serve to strengthen the newly learned association in a distributed memory network.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fadeev2023,

title = {Трудности с восприятием речи на фоне шума у детей с расстройствами аутистического спектра не связаны с уровнем их интеллекта},

author = {Фадеев, К.А. and Гояева, Д.Э. and Обухова, Т.С. and Овсянникова, Т.М. and Шведовский, Е.Ф. and Николаева, А.Ю. and Давыдова, Е.Ю. and Строганова, Т.А. and Орехова, Е.В.},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.17759_cpse.2023120108.pdf},

doi = {10.17759/cpse.2023120108},

issn = {2304-0394},

year  = {2023},

date = {2023-04-10},

urldate = {2023-04-10},

journal = {Клиническая и специальная психология},

volume = {12},

number = {1},

pages = {180-212},

publisher = {Московский государственный психолого-педагогический университет},

abstract = {Известно, что детям с расстройствами аутистического спектра (РАС) сложнее, чем типично развивающимся сверстникам, понимать речь в шумной обстановке. В основе такого нарушения могут лежать снижение помехоустойчивости и/или трудности интеграции фрагментов речи, расслышанных в интервалах, которые имеются в окружающих шумах. Мы исследовали роль этих факторов в восприятии слов на фоне шума у детей с РАС с широким спектром интеллектуальных способностей. Выборку составили 42 ребенка с РАС и 38 типично развивающихся детей 7–12 лет. Детям предлагалось повторять двусложные слова, предъявляемые на фоне шума. Использовалось два типа маскировки: стационарный шум и шум, модулированный по амплитуде. Уровень интеллекта оценивался с помощью Батареи тестов Кауфмана для детей (KABC-II). Результаты свидетельствуют о том, что дети с РАС хуже, чем типично развивающиеся дети, распознавали слова на фоне стационарного шума, т.е. имели сниженную помехоустойчивость. Даже после поправки на помехоустойчивость, наличие интервалов сниженной интенсивности в шуме, модулированном по амплитуде, в меньшей степени улучшало распознавание слов у детей с РАС, чем у типично развивающихся детей (F(1,75)=18,57, p<0,001). Ни успешность восприятия слов на фоне стационарного шума, ни способность использовать для распознавания интервалы низкой интенсивности шума не коррелировали у детей с РАС с уровнем интеллекта (коэффициент Спирмена, все p>0,80). Трудности восприятия зашумленной речи у детей с РАС не зависят напрямую от уровня их когнитивных способностей и связаны как с низкой помехоустойчивостью, так и слабыми возможностями временной интеграции фонем в слова.

Портал психологических изданий PsyJournals.ru — https://psyjournals.ru/journals/cpse/archive/2023_n1/Fadeev_et_al [Трудности с восприятием речи на фоне шума у детей с расстройствами аутистического спектра не связаны с уровнем их интеллекта // Клиническая и специальная психология — 2023. Том 12. № 1]},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kozunov2020,

title = {Object recognition is enabled by an experience-dependent appraisal of visual features in the brain’s value system},

author = {Vladimir V. Kozunov and Timothy O. West and Anastasia Y. Nikolaeva and Tatiana A. Stroganova and Karl J. Friston},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1016_j.neuroimage.2020.117143.pdf},

doi = {10.1016/j.neuroimage.2020.117143},

issn = {1053-8119},

year  = {2020},

date = {2020-11-01},

urldate = {2020-11-01},

journal = {NeuroImage},

volume = {221},

pages = {117143},

publisher = {Elsevier BV},

abstract = {This paper addresses perceptual synthesis by comparing responses evoked by visual stimuli before and after they are recognized, depending on prior exposure. Using magnetoencephalography, we analyzed distributed patterns of neuronal activity – evoked by Mooney figures – before and after they were recognized as meaningful objects. Recognition induced changes were first seen at 100–120 ​ms, for both faces and tools. These early effects – in right inferior and middle occipital regions – were characterized by an increase in power in the absence of any changes in spatial patterns of activity. Within a later 210–230 ​ms window, a quite different type of recognition effect appeared. Regions of the brain’s value system (insula, entorhinal cortex and cingulate of the right hemisphere for faces and right orbitofrontal cortex for tools) evinced a reorganization of their neuronal activity without an overall power increase in the region. Finally, we found that during the perception of disambiguated face stimuli, a face-specific response in the right fusiform gyrus emerged at 240–290 ​ms, with a much greater latency than the well-known N170m component, and, crucially, followed the recognition effect in the value system regions. These results can clarify one of the most intriguing issues of perceptual synthesis, namely, how a limited set of high-level predictions, which is required to reduce the uncertainty when resolving the ill-posed inverse problem of perception, can be available before category-specific processing in visual cortex. We suggest that a subset of local spatial features serves as partial cues for a fast re-activation of object-specific appraisal by the value system. The ensuing top-down feedback from value system to visual cortex, in particular, the fusiform gyrus enables high levels of processing to form category-specific predictions. This descending influence of the value system was more prominent for faces than for tools, the fact that reflects different dependence of these categories on value-related information.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Razorenova2020b,

title = {Rapid Cortical Plasticity Induced by Active Associative Learning of Novel Words in Human Adults},

author = {Alexandra M. Razorenova and Boris V. Chernyshev and Anastasia Yu Nikolaeva and Anna V. Butorina and Andrey O. Prokofyev and Nikita B. Tyulenev and Tatiana A. Stroganova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnins.2020.00895.pdf},

doi = {10.3389/fnins.2020.00895},

issn = {1662-453X},

year  = {2020},

date = {2020-09-11},

urldate = {2020-09-11},

journal = {Frontiers in Neuroscience},

volume = {14},

pages = {895},

publisher = {Frontiers Media SA},

abstract = {Human speech requires that new words are routinely memorized, yet neurocognitive mechanisms of such acquisition of memory remain highly debatable. Major controversy concerns the question whether cortical plasticity related to word learning occurs in neocortical speech-related areas immediately after learning, or neocortical plasticity emerges only on the second day after a prolonged time required for consolidation after learning. The functional spatiotemporal pattern of cortical activity related to such learning also remains largely unknown. In order to address these questions, we examined magnetoencephalographic responses elicited in the cerebral cortex by passive presentations of eight novel pseudowords before and immediately after an operant conditioning task. This associative procedure forced participants to perform an active search for unique meaning of four pseudowords that referred to movements of left and right hands and feet. The other four pseudowords did not require any movement and thus were not associated with any meaning. Familiarization with novel pseudowords led to a bilateral repetition suppression of cortical responses to them; the effect started before or around the uniqueness point and lasted for more than 500 ms. After learning, response amplitude to pseudowords that acquired meaning was greater compared with response amplitude to pseudowords that were not assigned meaning; the effect was significant within 144–362 ms after the uniqueness point, and it was found only in the left hemisphere. Within this time interval, a learning-related selective response initially emerged in cortical areas surrounding the Sylvian fissure: anterior superior temporal sulcus, ventral premotor cortex, the anterior part of intraparietal sulcus and insula. Later within this interval, activation additionally spread to more anterior higher-tier brain regions, and reached the left temporal pole and the triangular part of the left inferior frontal gyrus extending to its orbital part. Altogether, current findings evidence rapid plastic changes in cortical representations of meaningful auditory word-forms occurring almost immediately after learning. Additionally, our results suggest that familiarization resulting from stimulus repetition and semantic acquisition resulting from an active learning procedure have separable effects on cortical activity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Orekhova2020,

title = {Spatial suppression in visual motion perception is driven by inhibition: Evidence from MEG gamma oscillations},

author = {Elena V. Orekhova and Ekaterina N. Rostovtseva and Viktoriya O. Manyukhina and Andrey O. Prokofiev and Tatiana S. Obukhova and Anastasia Yu. Nikolaeva and Justin F. Schneiderman and Tatiana A. Stroganova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1016_j.neuroimage.2020.116753.pdf},

doi = {10.1016/j.neuroimage.2020.116753},

issn = {1053-8119},

year  = {2020},

date = {2020-06-00},

urldate = {2020-06-00},

journal = {NeuroImage},

volume = {213},

pages = {116753},

publisher = {Elsevier BV},

abstract = {Spatial suppression (SS) is a visual perceptual phenomenon that is manifest in a reduction of directional sensitivity for drifting high-contrast gratings whose size exceeds the center of the visual field. Gratings moving at faster velocities induce stronger SS. The neural processes that give rise to such size- and velocity-dependent reductions in directional sensitivity are currently unknown, and the role of surround inhibition is unclear. In magnetoencephalogram (MEG), large high-contrast drifting gratings induce a strong gamma response (GR), which also attenuates with an increase in the gratings’ velocity. It has been suggested that the slope of this GR attenuation is mediated by inhibitory interactions in the primary visual cortex. Herein, we investigate whether SS is related to this inhibitory-based MEG measure. We evaluated SS and GR in two independent samples of participants: school-age boys and adult women. The slope of GR attenuation predicted inter-individual differences in SS in both samples. Test-retest reliability of the neuro-behavioral correlation was assessed in the adults, and was high between two sessions separated by several days or weeks. Neither frequencies nor absolute amplitudes of the GRs correlated with SS, which highlights the functional relevance of velocity-related changes in GR magnitude caused by augmentation of incoming input. Our findings provide evidence that links the psychophysical phenomenon of SS to inhibitory-based neural responses in the human primary visual cortex. This supports the role of inhibitory interactions as an important underlying mechanism for spatial suppression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Orekhova2020b,

title = {Additive effect of contrast and velocity suggests the role of strong excitatory drive in suppression of visual gamma response},

author = {Elena V. Orekhova and Andrey O. Prokofyev and Anastasia Yu. Nikolaeva and Justin F. Schneiderman and Tatiana A. Stroganova},

editor = {César Rennó‐Costa},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1371_journal.pone.0228937.pdf},

doi = {10.1371/journal.pone.0228937},

issn = {1932-6203},

year  = {2020},

date = {2020-02-13},

urldate = {2020-02-13},

journal = {PLoS ONE},

volume = {15},

number = {2},

pages = {e0228937},

publisher = {Public Library of Science (PLoS)},

abstract = {It is commonly acknowledged that gamma-band oscillations arise from interplay between neural excitation and inhibition; however, the neural mechanisms controlling the power of stimulus-induced gamma responses (GR) in the human brain remain poorly understood. A moderate increase in velocity of drifting gratings results in GR power enhancement, while increasing the velocity beyond some ‘transition point’ leads to GR power attenuation. We tested two alternative explanations for this nonlinear input-output dependency in the GR power. First, the GR power can be maximal at the preferable velocity/temporal frequency of motion-sensitive V1 neurons. This ‘velocity tuning’ hypothesis predicts that lowering contrast either will not affect the transition point or shift it to a lower velocity. Second, the GR power attenuation at high velocities of visual motion can be caused by changes in excitation/inhibition balance with increasing excitatory drive. Since contrast and velocity both add to excitatory drive, this ‘excitatory drive’ hypothesis predicts that the ‘transition point’ for low-contrast gratings would be reached at a higher velocity, as compared to high-contrast gratings. To test these alternatives, we recorded magnetoencephalography during presentation of low (50%) and high (100%) contrast gratings drifting at four velocities. We found that lowering contrast led to a highly reliable shift of the GR suppression transition point to higher velocities, thus supporting the excitatory drive hypothesis. No effects of contrast or velocity were found in the alpha-beta range. The results have implications for understanding the mechanisms of gamma oscillations and developing gamma-based biomarkers of disturbed excitation/inhibition balance in brain disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pavlova2019b,

title = {Effortful verb retrieval from semantic memory drives beta suppression in mesial frontal regions involved in action initiation},

author = {Anna A. Pavlova and Anna V. Butorina and Anastasia Y. Nikolaeva and Andrey O. Prokofyev and Maxim A. Ulanov and Denis P. Bondarev and Tatiana A. Stroganova},

url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.24624},

doi = {10.1002/hbm.24624},

issn = {1097-0193},

year  = {2019},

date = {2019-08-15},

urldate = {2019-08-15},

journal = {Human Brain Mapping},

volume = {40},

number = {12},

pages = {3669-3681},

publisher = {Wiley},

abstract = {The contribution of the motor cortex to the semantic retrieval of verbs remains a subject of debate in neuroscience. Here, we examined whether additional engagement of the cortical motor system was required when access to verbs semantics was hindered during a verb generation task. We asked participants to produce verbs related to presented noun cues that were either strongly associated with a single verb to prompt fast and effortless verb retrieval, or were weakly associated with multiple verbs and more difficult to respond to. Using power suppression of magnetoencephalography beta oscillations (15–30 Hz) as an index of cortical activation, we performed a whole‐brain analysis in order to identify the cortical regions sensitive to the difficulty of verb semantic retrieval. Highly reliable suppression of beta oscillations occurred 250 ms after the noun cue presentation and was sustained until the onset of verbal response. This was localized to multiple cortical regions, mainly in the temporal and frontal lobes of the left hemisphere. Crucially, the only cortical regions where beta suppression was sensitive to the task difficulty, were the higher order motor areas on the medial and lateral surfaces of the frontal lobe. Stronger activation of the premotor cortex and supplementary motor area accompanied the effortful verb retrieval and preceded the preparation of verbal responses for more than 500 ms, thus, overlapping with the time window of verb retrieval from semantic memory. Our results suggest that reactivation of verb‐related motor plans in higher order motor circuitry promotes the semantic retrieval of target verbs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kozunov2018,

title = {Categorization for Faces and Tools—Two Classes of Objects Shaped by Different Experience—Differs in Processing Timing, Brain Areas Involved, and Repetition Effects},

author = {Vladimir Kozunov and Anastasia Nikolaeva and Tatiana A. Stroganova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnhum.2017.00650.pdf},

doi = {10.3389/fnhum.2017.00650},

issn = {1662-5161},

year  = {2018},

date = {2018-01-09},

urldate = {2018-01-09},

journal = {Frontiers in Human Neuroscience},

volume = {11},

pages = {650},

publisher = {Frontiers Media SA},

abstract = {The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se, or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140–170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210–220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions. Furthermore, we hypothesized and tested whether activity within face and tool-specific binding-related patterns would demonstrate oppositely acting effects following procedural perceptual learning. We found that activity in the ventral, face-specific network increased following the stimuli repetition. In contrast, tool processing in the dorsal network adapted by reducing its activity over the repetition period. Altogether, we have demonstrated that activity associated with visual processing of faces and tools during the categorization stage differ in processing timing, brain areas involved, and in their dynamics underlying stimuli learning.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Николаева2018,

title = {Влияние лексико-семантической обработки глаголов движения рук и ног на указательные движения тех же конечностей},

author = {А. Ю. Николаева and Т. А. Строганова},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1134_s0044467718050118.pdf},

doi = {10.1134/s0044467718050118},

issn = {0044-4677},

year  = {2018},

date = {2018-00-00},

urldate = {2018-00-00},

journal = {Журнал высшей нервной деятельности им. И.П.Павлова},

volume = {68},

number = {5},

pages = {627-636},

publisher = {Российская академия наук},

abstract = {Согласно теории ассоциативного обучения, при восприятии глаголов “ходить” или “писать” происходит реактивация моторных нейронных репрезентаций руки или ноги, вовлеченных в осуществление соответствующих действий. Общая активация моторных зон

должна приводить к эффектам интерференции, т.е. к замедлению движения определенной

конечности при семантической обработке глагола, обозначающего ее движения. Целью

работы был анализ избирательности эффектов интерференции семантической обработки

глаголов, обозначающих движения рук и ног, с движениями этих же конечностей. Перед

испытуемыми (14 женщин, 14 мужчин, средний возраст 28 лет) стояла семантическая задача – определить конкретность/абстрактность глаголов, включавших в том числе глаголы

движения рук и ног. Испытуемые отвечали либо рукой, либо ногой, как правой, так и левой в зависимости от серии эксперимента. Результаты исследования показали, что обработка семантической информации о глаголах движения интерферирует с одновременными произвольными движениями конечностей, но не по соматотопическому принципу.

Выявленная избирательная интерференция говорит о том, что структуры левого полушария, вовлеченные в восприятие глаголов, частично задействуют те же мозговые механизмы, что и инициация движений правых конечностей, в особенности движений правой руки. Наши результаты не опровергают теорию ассоциативного обучения речи, но показывают, что ее предсказания нельзя проверить с помощью предназначенных для этой цели

поведенческих экспериментов.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Not all reading is alike: task modulation of magnetic evoked response to visual word},

author = {Pavlova, Anna A. and Butorina, Anna V. and Nikolaeva, Anastasia Y. and Prokofyev, Andrey O. and Ulanov, Maxim A. and Stroganova, Tatiana A.},

doi = {10.11621/pir.2017.0313},

year  = {2017},

date = {2017-12-00},

journal = {Psychology in Russia: State of the art},

volume = {10},

number = {3},

pages = {190-205},

publisher = {Russian Psychology Society},

abstract = {Background. 

Previous studies have shown that brain response to a written word depends on the task: whether the word is a target in a version of lexical decision task or should be read silently. Although this effect has been interpreted as an evidence for an interaction between word recognition processes and task demands, it also may be caused by greater attention allocation to the target word. 



Objective. 

We aimed to examine the task effect on brain response evoked by non-target written words. 



Design. 

Using MEG and magnetic source imaging, we compared spatial-temporal pattern of brain response elicited by a noun cue when it was read silently either without additional task (SR) or with a requirement to produce an associated verb (VG). 



Results. 

The task demands penetrated into early (200-300 ms) and late (500-800 ms) stages of a word processing by enhancing brain response under VG versus SR condition. The cortical sources of the early response were localized to bilateral inferior occipitotem-poral and anterior temporal cortex suggesting that more demanding VG task required elaborated lexical-semantic analysis. The late effect was observed in the associative auditory areas in middle and superior temporal gyri and in motor representation of articulators. Our results suggest that a remote goal plays a pivotal role in enhanced recruitment of cortical structures underlying orthographic, semantic and sensorimotor dimensions of written word perception from the early processing stages. Surprisingly, we found that to full a more challenging goal the brain progressively engaged resources of the right hemisphere throughout all stages of silent reading. Conclusion. Our study demonstrates that a deeper processing of linguistic input amplies activation of brain areas involved in integration of speech perception and pro-duction. This is consistent with theories that emphasize the role of sensorimotor integration in speech understanding.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Butorina2017,

title = {Simultaneous Processing of Noun Cue and to-be-Produced Verb in Verb Generation Task: Electromagnetic Evidence},

author = {Anna V. Butorina and Anna A. Pavlova and Anastasia Y. Nikolaeva and Andrey O. Prokofyev and Denis P. Bondarev and Tatiana A. Stroganova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnhum.2017.00279.pdf},

doi = {10.3389/fnhum.2017.00279},

issn = {1662-5161},

year  = {2017},

date = {2017-05-30},

urldate = {2017-05-30},

journal = {Frontiers in Human Neuroscience},

volume = {11},

pages = {279},

publisher = {Frontiers Media SA},

abstract = {A long-standing but implicit assumption is that words strongly associated with a presented cue are automatically activated in the memory through rapid spread of activation within brain semantic networks. The current study was aimed to provide direct evidence of such rapid access to words’ semantic representations and to investigate its neural sources using magnetoencephalography (MEG) and distributed source localization technique. Thirty-three neurotypical subjects underwent the MEG recording during verb generation task, which was to produce verbs related to the presented noun cues. Brain responses evoked by the noun cues were examined while manipulating the strength of association between the noun and the potential verb responses. The strong vs. weak noun-verb association led to a greater noun-related neural response at 250–400 ms after cue onset, and faster verb production. The cortical sources of the differential response were localized in left temporal pole, previously implicated in semantic access, and left ventrolateral prefrontal cortex (VLPFC), thought to subserve controlled semantic retrieval. The strength of the left VLPFC’s response to the nouns with strong verb associates was positively correlated to the speed of verbs production. Our findings empirically validate the theoretical expectation that in case of a strongly connected noun-verb pair, successful access to target verb representation may occur already at the stage of lexico-semantic analysis of the presented noun. Moreover, the MEG results suggest that contrary to the previous conclusion derived from fMRI studies left VLPFC supports selection of the target verb representations, even if they were retrieved from semantic memory rapidly and effortlessly. The discordance between MEG and fMRI findings in verb generation task may stem from different modes of neural activation captured by phase-locked activity in MEG and slow changes of blood-oxygen-level-dependent (BOLD) signal in fMRI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Stroganova2015,

title = {Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders},

author = {Tatiana A. Stroganova and Anna V. Butorina and Olga V. Sysoeva and Andrey O. Prokofyev and Anastasia Yu. Nikolaeva and Marina M. Tsetlin and Elena V. Orekhova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1186_s11689-015-9121-x.pdf},

doi = {10.1186/s11689-015-9121-x},

issn = {1866-1955},

year  = {2015},

date = {2015-12-00},

urldate = {2015-12-00},

journal = {Journal of Neurodevelopmental Disorders},

volume = {7},

number = {1},

pages = {21},

publisher = {Springer Science and Business Media LLC},

abstract = {Background

Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50–120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of excitation of the fast-spiking inhibitory basket cells recruited by increasing strength of excitatory input. Therefore, the experimental manipulations affecting gamma frequency may throw light on inhibitory networks dysfunction in ASD.



Methods

Here, we used magnetoencephalography (MEG) to investigate modulation of visual gamma oscillation frequency by speed of drifting annular gratings (1.2, 3.6, 6.0 °/s) in 21 boys with ASD and 26 typically developing boys aged 7–15 years. Multitaper method was used for analysis of spectra of gamma power change upon stimulus presentation and permutation test was applied for statistical comparisons. We also assessed in our participants visual orientation discrimination thresholds, which are thought to depend on excitability of inhibitory networks in the visual cortex.



Results

Although frequency of the oscillatory gamma response increased with increasing velocity of visual motion in both groups of participants, the velocity effect was reduced in a substantial proportion of children with ASD. The range of velocity-related gamma frequency modulation correlated inversely with the ability to discriminate oblique line orientation in the ASD group, while no such correlation has been observed in the group of typically developing participants.



Conclusions

Our findings suggest that abnormal velocity-related gamma frequency modulation in ASD may constitute a potential biomarker for reduced excitability of fast-spiking inhibitory neurons in a subset of children with ASD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Orekhova2015,

title = {Frequency of gamma oscillations in humans is modulated by velocity of visual motion},

author = {Elena V. Orekhova and Anna V. Butorina and Olga V. Sysoeva and Andrey O. Prokofyev and Anastasia Yu. Nikolaeva and Tatiana A. Stroganova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1152_jn.00232.2015.pdf},

doi = {10.1152/jn.00232.2015},

issn = {1522-1598},

year  = {2015},

date = {2015-07-00},

urldate = {2015-07-00},

journal = {Journal of Neurophysiology},

volume = {114},

number = {1},

pages = {244-255},

publisher = {American Physiological Society},

abstract = {Gamma oscillations are generated in networks of inhibitory fast-spiking (FS) parvalbumin-positive (PV) interneurons and pyramidal cells. In animals, gamma frequency is modulated by the velocity of visual motion; the effect of velocity has not been evaluated in humans. In this work, we have studied velocity-related modulations of gamma frequency in children using MEG/EEG. We also investigated whether such modulations predict the prominence of the "spatial suppression" effect (Tadin D, Lappin JS, Gilroy LA, Blake R. Nature 424: 312-315, 2003) that is thought to depend on cortical center-surround inhibitory mechanisms. MEG/EEG was recorded in 27 normal boys aged 8-15 yr while they watched high-contrast black-and-white annular gratings drifting with velocities of 1.2, 3.6, and 6.0°/s and performed a simple detection task. The spatial suppression effect was assessed in a separate psychophysical experiment. MEG gamma oscillation frequency increased while power decreased with increasing velocity of visual motion. In EEG, the effects were less reliable. The frequencies of the velocity-specific gamma peaks were 64.9, 74.8, and 87.1 Hz for the slow, medium, and fast motions, respectively. The frequency of the gamma response elicited during slow and medium velocity of visual motion decreased with subject age, whereas the range of gamma frequency modulation by velocity increased with age. The frequency modulation range predicted spatial suppression even after controlling for the effect of age. We suggest that the modulation of the MEG gamma frequency by velocity of visual motion reflects excitability of cortical inhibitory circuits and can be used to investigate their normal and pathological development in the human brain.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {[Lateralized brain language semantic network demonstrated by word repetition suppression effect in MEG]},

author = {Nikolaeva, A.Y. and Butorina, A.V. and Prokofyev, A.O. and Stroganova, T.A.},

year  = {2015},

date = {2015-01-00},

urldate = {2015-01-00},

journal = {Zh Vyssh Nerv Deiat Im I P Pavlova},

volume = {65},

pages = {82-91},

abstract = {We studied auditory word repetition suppression effect using magnetoencephalography while subjects listened to "new" and "old" words whose familiarity they had to judge upon presentation. The lateralization of brain magnetic activity during processing of "new" and "old" words were estimated by computing RMS measure of whole-brain magnetic response within time window of semantic N400 (350-450 ms). A magnetic N400 was significantly stronger in the left than in the right hemisphere for the "new" words only. Repetition of "new" words led to sharp decrease of N400 response RMS in the left hemisphere but did not change right-hemispheric N400 RMS. The asymmetry index of this repetition suppression effect was lateralized to the left hemisphere for the majority of the participants and its magnitude was related to memory task performance. The findings point to a strong left-hemispheric dominance of word repetition suppression effect within the brain semantic networks at the level of whole-network response.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shtyrov2014,

title = {Automatic ultrarapid activation and inhibition of cortical motor systems in spoken word comprehension},

author = {Yury Shtyrov and Anna Butorina and Anastasia Nikolaeva and Tatiana Stroganova},

url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1073_pnas.1323158111.pdf},

doi = {10.1073/pnas.1323158111},

issn = {1091-6490},

year  = {2014},

date = {2014-05-06},

urldate = {2014-05-06},

journal = {Proceedings of the National Academy of Sciences},

volume = {111},

number = {18},

pages = {E1918-E1923},

address = {USA},

abstract = {Significance

The mechanisms through which our brain generates complex cognitive percepts from simple sensory and motor events remain unknown. An important question is whether the basic brain structures controlling movements and perceptions directly participate in higher-order cognitive processes such as language comprehension. Using neurophysiology, we found ultrarapid (starting at ∼80 ms) activations in the human motor cortex in response to unattended action-related verbs and nouns, with words related to different body parts activating corresponding body representations. Accompanying this category-specific activity was activation suppression by words with area-incompatible meaning, demonstrating operation of the neurophysiological principles of lateral/surround inhibition in language processing. These instant activations and deactivations emerging for words of different types in the absence of attention advocate automatic involvement of neural sensorimotor circuits in language comprehension.



Abstract

To address the hotly debated question of motor system involvement in language comprehension, we recorded neuromagnetic responses elicited in the human brain by unattended action-related spoken verbs and nouns and scrutinized their timecourse and neuroanatomical substrates. We found that already very early on, from ∼80 ms after disambiguation point when the words could be identified from the available acoustic information, both verbs and nouns produced characteristic somatotopic activations in the motor strip, with words related to different body parts activating the corresponding body representations. Strikingly, along with this category-specific activation, we observed suppression of motor-cortex activation by competitor words with incompatible semantics, documenting operation of the neurophysiological principles of lateral/surround inhibition in neural word processing. The extremely early onset of these activations and deactivations, their emergence in the absence of attention, and their similar presence for words of different lexical classes strongly suggest automatic involvement of motor-specific circuits in the perception of action-related language.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}