Stroganova Tatyana
Senior researcher
Doctor of Sciences in Biology, Professor
Publications:
2025
53.
Obukhova, Tatiana S.; Stroganova, Tatiana A.; Artemenko, Ada R.; Petrokovskaia, Anastasiia V.; Orekhova, Elena V. (2025). Directional motion sensitivity in people with Visual Snow Syndrome is modulated by the presence of trailing-type palinopsia. Investigative Ophthalmology & Visual Science, 66(4), 24. https://doi.org/10.1167/iovs.66.4.24
@article{nokey,
title = {Directional motion sensitivity in people with Visual Snow Syndrome is modulated by the presence of trailing-type palinopsia},
author = {Tatiana S. Obukhova and Tatiana A. Stroganova and Ada R. Artemenko and Anastasiia V. Petrokovskaia and Elena V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1167_iovs.66.4.24.pdf},
doi = {10.1167/iovs.66.4.24},
year = {2025},
date = {2025-04-02},
urldate = {2025-04-02},
journal = {Investigative Ophthalmology & Visual Science},
volume = {66},
number = {4},
pages = {24},
abstract = {Purpose: Visual Snow Syndrome (VSS) is characterized by visual perceptual distortions, potentially linked to increased neural excitability and/or decreased inhibition in the visual cortex. If present, these putative physiological abnormalities may alter motion direction sensitivity. Trailing-type palinopsia (TTP), commonly associated with VSS, may further affect motion sensitivity. This study aimed to investigate the sensitivity to direction of motion and its dependence on stimulus size in patients with VSS using the Spatial Suppression paradigm.
Methods: We assessed motion duration discrimination thresholds for small (1 degree), medium (2.5 degrees), and large (12 degrees) high-contrast gratings in 23 patients with VSS and 27 healthy control participants. The Spatial Suppression Index (SSI) quantified size-dependent increases in duration thresholds. Visual Discomfort Questionnaire scores and VSS symptom ratings, including TTP, afterimages, photophobia, etc., were also collected.
Results: Patients with VSS reported higher visual discomfort and perceptual disturbances, but no group differences were found in duration thresholds or SSI. Notably, higher TTP scores were associated with lower duration thresholds, indicating a facilitatory effect of TTP on sensitivity to direction of motion.
Conclusions: Our findings indicate that when VSS is regarded as a unified diagnostic category, it is not associated with impaired motion direction sensitivity or abnormal center-surround suppression. However, our preliminary results suggest that an absence or presence of comorbid TTP has a qualitatively different effect on directional sensitivity in patients with VSS. The facilitatory effect of TTP on motion sensitivity provides insight into the functional concomitants of TTP, and warrants further exploration, as it may significantly influence experimental outcomes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Purpose: Visual Snow Syndrome (VSS) is characterized by visual perceptual distortions, potentially linked to increased neural excitability and/or decreased inhibition in the visual cortex. If present, these putative physiological abnormalities may alter motion direction sensitivity. Trailing-type palinopsia (TTP), commonly associated with VSS, may further affect motion sensitivity. This study aimed to investigate the sensitivity to direction of motion and its dependence on stimulus size in patients with VSS using the Spatial Suppression paradigm.
Methods: We assessed motion duration discrimination thresholds for small (1 degree), medium (2.5 degrees), and large (12 degrees) high-contrast gratings in 23 patients with VSS and 27 healthy control participants. The Spatial Suppression Index (SSI) quantified size-dependent increases in duration thresholds. Visual Discomfort Questionnaire scores and VSS symptom ratings, including TTP, afterimages, photophobia, etc., were also collected.
Results: Patients with VSS reported higher visual discomfort and perceptual disturbances, but no group differences were found in duration thresholds or SSI. Notably, higher TTP scores were associated with lower duration thresholds, indicating a facilitatory effect of TTP on sensitivity to direction of motion.
Conclusions: Our findings indicate that when VSS is regarded as a unified diagnostic category, it is not associated with impaired motion direction sensitivity or abnormal center-surround suppression. However, our preliminary results suggest that an absence or presence of comorbid TTP has a qualitatively different effect on directional sensitivity in patients with VSS. The facilitatory effect of TTP on motion sensitivity provides insight into the functional concomitants of TTP, and warrants further exploration, as it may significantly influence experimental outcomes.
Methods: We assessed motion duration discrimination thresholds for small (1 degree), medium (2.5 degrees), and large (12 degrees) high-contrast gratings in 23 patients with VSS and 27 healthy control participants. The Spatial Suppression Index (SSI) quantified size-dependent increases in duration thresholds. Visual Discomfort Questionnaire scores and VSS symptom ratings, including TTP, afterimages, photophobia, etc., were also collected.
Results: Patients with VSS reported higher visual discomfort and perceptual disturbances, but no group differences were found in duration thresholds or SSI. Notably, higher TTP scores were associated with lower duration thresholds, indicating a facilitatory effect of TTP on sensitivity to direction of motion.
Conclusions: Our findings indicate that when VSS is regarded as a unified diagnostic category, it is not associated with impaired motion direction sensitivity or abnormal center-surround suppression. However, our preliminary results suggest that an absence or presence of comorbid TTP has a qualitatively different effect on directional sensitivity in patients with VSS. The facilitatory effect of TTP on motion sensitivity provides insight into the functional concomitants of TTP, and warrants further exploration, as it may significantly influence experimental outcomes.
2024
52.
Fadeev, Kirill A.; Romero Reyes, Ilacai V.; Goiaeva, Dzerassa E.; Obukhova, Tatiana S.; Ovsiannikova, Tatiana M.; Prokofyev, Andrey O.; Rytikova, Anna M.; Novikov, Artem Y.; Kozunov, Vladimir V.; Stroganova, Tatiana A.; Orekhova, Elena V. (2024). Attenuated processing of vowels in the left temporal cortex predicts speech-in-noise perception deficit in children with autism. Journal of Neurodevelopmental Disorders, 16(1). https://doi.org/10.1186/s11689-024-09585-2
@article{Fadeev2024,
title = {Attenuated processing of vowels in the left temporal cortex predicts speech-in-noise perception deficit in children with autism},
author = {Kirill A. Fadeev and Romero Reyes, Ilacai V. and Dzerassa E. Goiaeva and Tatiana S. Obukhova and Tatiana M. Ovsiannikova and Andrey O. Prokofyev and Anna M. Rytikova and Artem Y. Novikov and Vladimir V. Kozunov and Tatiana A. Stroganova and Elena V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1186_s11689-024-09585-2.pdf},
doi = {10.1186/s11689-024-09585-2},
year = {2024},
date = {2024-12-06},
urldate = {2024-12-06},
journal = {Journal of Neurodevelopmental Disorders},
volume = {16},
number = {1},
publisher = {Springer Science and Business Media LLC},
abstract = {Background
Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory “object”.
Methods
We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio.
Results
SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150—200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise.
Conclusions
These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background
Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory “object”.
Methods
We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio.
Results
SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150—200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise.
Conclusions
These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.
Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory “object”.
Methods
We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio.
Results
SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150—200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise.
Conclusions
These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.
51.
Pultsina, Kristina I.; Stroganova, Tatiana A.; Kozunova, Galina L.; Prokofyev, Andrey O.; Miasnikova, Aleksandra S.; Rytikova, Anna M.; Chernyshev, Boris V. (2024). Atypical pupil-linked arousal induced by low-risk probabilistic choices, and intolerance of uncertainty in adults with ASD. Cognitive, Affective, & Behavioral Neuroscience, 25(2), 531-549. https://doi.org/10.3758/s13415-024-01227-3
@article{Pultsina2024,
title = {Atypical pupil-linked arousal induced by low-risk probabilistic choices, and intolerance of uncertainty in adults with ASD},
author = {Kristina I. Pultsina and Tatiana A. Stroganova and Galina L. Kozunova and Andrey O. Prokofyev and Aleksandra S. Miasnikova and Anna M. Rytikova and Boris V. Chernyshev},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3758_s13415-024-01227-3.pdf},
doi = {10.3758/s13415-024-01227-3},
year = {2024},
date = {2024-11-19},
urldate = {2024-11-19},
journal = { Cognitive, Affective, & Behavioral Neuroscience },
volume = {25},
number = {2},
pages = {531-549},
publisher = {Springer Science and Business Media LLC},
abstract = {Adults with autism spectrum disorder (ASD) experience stress when operating in a probabilistic environment, even if it is familiar, but the underlying mechanisms remain unclear. Their decision-making may be affected by the uncertainty aversion implicated in ASD and associated with increased autonomic arousal. Previous studies have shown that in neurotypical (NT) people, decisions with predictably better outcomes are less stressful and elicit smaller pupil-linked arousal than those involving exploration. Here, in a sample of 46 high-functioning ASD and NT participants, using mixed-effects model analysis, we explored pupil-linked arousal and behavioral performance in a probabilistic reward learning task with a stable advantage of one choice option over the other. We found that subjects with ASD learned and preferred advantageous probabilistic choices at the same rate and to the same extent as NT participants, both in terms of choice ratio and response time. Although both groups exhibited similar predictive behaviors, learning to favor advantageous choices led to increased pupillary arousal for these choices in the ASD group, while it caused a decrease in pupillary arousal in the NT group. Moreover, greater pupil-linked arousal during decisions with higher expected value correlated with greater degree of self-reported intolerance of uncertainty in everyday life. Our results suggest that in a nonvolatile probabilistic environment, objectively good predictive abilities in people with ASD are coupled with elevated physiological stress and subjective uncertainty regarding the decisions with the best possible but still uncertain outcome that contributes to their intolerance of uncertainty.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Adults with autism spectrum disorder (ASD) experience stress when operating in a probabilistic environment, even if it is familiar, but the underlying mechanisms remain unclear. Their decision-making may be affected by the uncertainty aversion implicated in ASD and associated with increased autonomic arousal. Previous studies have shown that in neurotypical (NT) people, decisions with predictably better outcomes are less stressful and elicit smaller pupil-linked arousal than those involving exploration. Here, in a sample of 46 high-functioning ASD and NT participants, using mixed-effects model analysis, we explored pupil-linked arousal and behavioral performance in a probabilistic reward learning task with a stable advantage of one choice option over the other. We found that subjects with ASD learned and preferred advantageous probabilistic choices at the same rate and to the same extent as NT participants, both in terms of choice ratio and response time. Although both groups exhibited similar predictive behaviors, learning to favor advantageous choices led to increased pupillary arousal for these choices in the ASD group, while it caused a decrease in pupillary arousal in the NT group. Moreover, greater pupil-linked arousal during decisions with higher expected value correlated with greater degree of self-reported intolerance of uncertainty in everyday life. Our results suggest that in a nonvolatile probabilistic environment, objectively good predictive abilities in people with ASD are coupled with elevated physiological stress and subjective uncertainty regarding the decisions with the best possible but still uncertain outcome that contributes to their intolerance of uncertainty.
50.
Vander, Tatiana; Bikmullina, Rozaliya; Froimovich, Naomi; Stroganova, Tatiana A.; Nissenkorn, Andreea; Gilboa, Tal; Eliashiv, Dawn; Ekstein, Dana; Medvedovsky, Mordekhay (2024). Economic aspects of prolonged home video-EEG monitoring: a simulation study. Cost Effectiveness and Resource Allocation, 22(1). https://doi.org/10.1186/s12962-024-00568-7
@article{Vander2024,
title = {Economic aspects of prolonged home video-EEG monitoring: a simulation study},
author = {Tatiana Vander and Rozaliya Bikmullina and Naomi Froimovich and Tatiana A. Stroganova and Andreea Nissenkorn and Tal Gilboa and Dawn Eliashiv and Dana Ekstein and Mordekhay Medvedovsky},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1186_s12962-024-00568-7.pdf},
doi = {10.1186/s12962-024-00568-7},
issn = {1478-7547},
year = {2024},
date = {2024-08-10},
urldate = {2024-08-10},
journal = {Cost Effectiveness and Resource Allocation},
volume = {22},
number = {1},
publisher = {Springer Science and Business Media LLC},
abstract = {Introduction
Video EEG monitoring (VEM) is an important tool for characterizing clinical events suspected as seizures. It is also used for pre-surgical workups in patients with drug-resistant epilepsy (DRE). In-hospital VEM high cost, long admission waiting periods and some other inconveniences led to an interest in home VEM (HVEM). However, because antiseizure medications cannot be reduced at home, HVEM may require longer monitoring. While the economic aspect is one of the main motivations for HVEM, the cost of HVEM lasting several weeks has not been assessed.
Methods
We modeled the cost of HVEM for 8 weeks and compared it to the cost of 1-week in-hospital VEM. Additionally, we modeled the per-patient cost for a combination of HVEM and in-hospital VEM, considering that if in a proportion of patients HVEM fails to achieve its goal, they should undergo in-hospital VEM with drug reduction.
Results
The average cost of HVEM up to 4–6 weeks of monitoring was lower than that for the 1-week in-hospital VEM. Combining the 3-week HVEM with 1-week in-hospital VEM (if needed) reduced the per-patient cost by 6.6–28.6% as compared to the situation when all the patients with DRE were referred to the in-hospital VEM.
Conclusions
A prolonged intermittent HVEM can be cost-effective, especially if the minimal seizure frequency is about one seizure per week. The study findings support directing efforts into clinical trials and technology development.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction
Video EEG monitoring (VEM) is an important tool for characterizing clinical events suspected as seizures. It is also used for pre-surgical workups in patients with drug-resistant epilepsy (DRE). In-hospital VEM high cost, long admission waiting periods and some other inconveniences led to an interest in home VEM (HVEM). However, because antiseizure medications cannot be reduced at home, HVEM may require longer monitoring. While the economic aspect is one of the main motivations for HVEM, the cost of HVEM lasting several weeks has not been assessed.
Methods
We modeled the cost of HVEM for 8 weeks and compared it to the cost of 1-week in-hospital VEM. Additionally, we modeled the per-patient cost for a combination of HVEM and in-hospital VEM, considering that if in a proportion of patients HVEM fails to achieve its goal, they should undergo in-hospital VEM with drug reduction.
Results
The average cost of HVEM up to 4–6 weeks of monitoring was lower than that for the 1-week in-hospital VEM. Combining the 3-week HVEM with 1-week in-hospital VEM (if needed) reduced the per-patient cost by 6.6–28.6% as compared to the situation when all the patients with DRE were referred to the in-hospital VEM.
Conclusions
A prolonged intermittent HVEM can be cost-effective, especially if the minimal seizure frequency is about one seizure per week. The study findings support directing efforts into clinical trials and technology development.
Video EEG monitoring (VEM) is an important tool for characterizing clinical events suspected as seizures. It is also used for pre-surgical workups in patients with drug-resistant epilepsy (DRE). In-hospital VEM high cost, long admission waiting periods and some other inconveniences led to an interest in home VEM (HVEM). However, because antiseizure medications cannot be reduced at home, HVEM may require longer monitoring. While the economic aspect is one of the main motivations for HVEM, the cost of HVEM lasting several weeks has not been assessed.
Methods
We modeled the cost of HVEM for 8 weeks and compared it to the cost of 1-week in-hospital VEM. Additionally, we modeled the per-patient cost for a combination of HVEM and in-hospital VEM, considering that if in a proportion of patients HVEM fails to achieve its goal, they should undergo in-hospital VEM with drug reduction.
Results
The average cost of HVEM up to 4–6 weeks of monitoring was lower than that for the 1-week in-hospital VEM. Combining the 3-week HVEM with 1-week in-hospital VEM (if needed) reduced the per-patient cost by 6.6–28.6% as compared to the situation when all the patients with DRE were referred to the in-hospital VEM.
Conclusions
A prolonged intermittent HVEM can be cost-effective, especially if the minimal seizure frequency is about one seizure per week. The study findings support directing efforts into clinical trials and technology development.
49.
Manyukhina, Viktoriya O.; Prokofyev, Andrey O.; Obukhova, Tatiana S.; Stroganova, Tatiana A.; Orekhova, Elena V. (2024). Changes in high-frequency aperiodic 1/f slope and periodic activity reflect post-stimulus functional inhibition in the visual cortex. Imaging Neuroscience, 2, 1-24. https://doi.org/10.1162/imag_a_00146
@article{Manyukhina2024,
title = {Changes in high-frequency aperiodic 1/f slope and periodic activity reflect post-stimulus functional inhibition in the visual cortex},
author = {Viktoriya O. Manyukhina and Andrey O. Prokofyev and Tatiana S. Obukhova and Tatiana A. Stroganova and Elena V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1162_imag_a_00146.pdf},
doi = {10.1162/imag_a_00146},
issn = {2837-6056},
year = {2024},
date = {2024-04-10},
urldate = {2024-04-10},
journal = {Imaging Neuroscience},
volume = {2},
pages = {1-24},
publisher = {MIT Press},
abstract = {It has been shown that cessation of intensive sensory stimulation is associated with a transient increase in functional inhibition in the sensory cortical areas. However, the electrophysiological correlates of this post-stimulus inhibition in the human brain have not been thoroughly investigated. To investigate post-stimulus inhibition, we analyzed magnetoencephalogram (MEG) recorded at rest and after cessation of visual stimulation of varying intensity (high-contrast gratings drifting at a slow, medium, or high rate) in 25 healthy women aged 18–40 years. We analyzed condition- and intensity-related changes in MEG parameters sensitive to functional inhibition: periodic alpha-beta power, peak alpha frequency (PAF), and 1/f aperiodic slope. We also investigated the association of these parameters with sensory sensitivity and avoidance assessed by a questionnaire. To evaluate the influence of hormonal status on the studied parameters, participants were examined twice, during the follicular and luteal phases of the menstrual cycle (MC). Regardless of the MC phase, increasing drift rate of visual gratings resulted in a proportional increase of post-stimulus posterior alpha-beta power, PAF, and a negative shift of the aperiodic (1/f) slope of the power spectrum in the high-frequency range. Compared to rest, the post-stimulus periods were characterized by higher PAF, more negative 1/f slope in posterior cortical areas, and a widespread increase in beta power. While condition- and drift-rate-dependent modulations of alpha-beta power and 1/f slope were correlated, changes in PAF did not correlate with either of them. A greater intensity-dependent increase in visual alpha-beta power predicted higher subjective sensory sensitivity/avoidance, suggesting stronger regulatory top-down modulation of the visual cortex in individuals with heightened sensitivity. Our results show that several MEG parameters concordantly indicate a post-stimulus enhancement of inhibition that is proportional to the intensity of the preceding visual stimulation. While post-stimulus changes in alpha-beta power and 1/f slope may share some common mechanisms, changes in PAF reflect a distinct aspect of inhibitory regulation. Our results inform potential inhibition-based biomarkers for clinical and translational research.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
It has been shown that cessation of intensive sensory stimulation is associated with a transient increase in functional inhibition in the sensory cortical areas. However, the electrophysiological correlates of this post-stimulus inhibition in the human brain have not been thoroughly investigated. To investigate post-stimulus inhibition, we analyzed magnetoencephalogram (MEG) recorded at rest and after cessation of visual stimulation of varying intensity (high-contrast gratings drifting at a slow, medium, or high rate) in 25 healthy women aged 18–40 years. We analyzed condition- and intensity-related changes in MEG parameters sensitive to functional inhibition: periodic alpha-beta power, peak alpha frequency (PAF), and 1/f aperiodic slope. We also investigated the association of these parameters with sensory sensitivity and avoidance assessed by a questionnaire. To evaluate the influence of hormonal status on the studied parameters, participants were examined twice, during the follicular and luteal phases of the menstrual cycle (MC). Regardless of the MC phase, increasing drift rate of visual gratings resulted in a proportional increase of post-stimulus posterior alpha-beta power, PAF, and a negative shift of the aperiodic (1/f) slope of the power spectrum in the high-frequency range. Compared to rest, the post-stimulus periods were characterized by higher PAF, more negative 1/f slope in posterior cortical areas, and a widespread increase in beta power. While condition- and drift-rate-dependent modulations of alpha-beta power and 1/f slope were correlated, changes in PAF did not correlate with either of them. A greater intensity-dependent increase in visual alpha-beta power predicted higher subjective sensory sensitivity/avoidance, suggesting stronger regulatory top-down modulation of the visual cortex in individuals with heightened sensitivity. Our results show that several MEG parameters concordantly indicate a post-stimulus enhancement of inhibition that is proportional to the intensity of the preceding visual stimulation. While post-stimulus changes in alpha-beta power and 1/f slope may share some common mechanisms, changes in PAF reflect a distinct aspect of inhibitory regulation. Our results inform potential inhibition-based biomarkers for clinical and translational research.
48.
Chernyshev, B. V.; Pavlova, A. A.; Rytikova, A. M.; Butorina, A. V.; Stroganova, T. A. (2024). Prolongation of Cerebral Activation in Response to a Stimulus as a Probable Mechanism of Associative Plasticity during Semantic Learning. Neuroscience and Behavioral Physiology, 54(3), 434-447. https://doi.org/10.1007/s11055-024-01610-0
@article{Chernyshev2024,
title = {Prolongation of Cerebral Activation in Response to a Stimulus as a Probable Mechanism of Associative Plasticity during Semantic Learning},
author = {B. V. Chernyshev and A. A. Pavlova and A. M. Rytikova and A. V. Butorina and T. A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1007_s11055-024-01610-0.pdf},
doi = {10.1007/s11055-024-01610-0},
issn = {1573-899X},
year = {2024},
date = {2024-03-00},
urldate = {2024-03-00},
journal = {Neuroscience and Behavioral Physiology },
volume = {54},
number = {3},
pages = {434-447},
publisher = {Springer Science and Business Media LLC},
abstract = {Remembering the meanings of new spoken words is believed to occur as a result of associative learning. For example, this is how words denoting movements can be compared with their corresponding motor acts. Synaptic plasticity is known to develop in the brain when the activity of the cellular ensembles representing associated events coincides in time. However, in reality, such associations can develop when there is a significant time gap between the events to be associated, violating the conditions required for the occurrence of synaptic plasticity. We suggested that the conditions required for the development of synaptic plasticity in the brain can be created if the activity of neural representations is prolonged in time such that the required overlap in time at the level of neural ensembles is achieved. To test this assumption, we recorded magnetoencephalograms from voluntary participants during the development of associations between pseudowords and movements of the four limbs. The results obtained here show that there is indeed a significant prolongation of stimulus-induced auditory-verbal activation when new associations develop. Thus, during the development of an association, conditions can be created in the brain for the development of Hebbian plasticity, even if the associated events are separated in time.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Remembering the meanings of new spoken words is believed to occur as a result of associative learning. For example, this is how words denoting movements can be compared with their corresponding motor acts. Synaptic plasticity is known to develop in the brain when the activity of the cellular ensembles representing associated events coincides in time. However, in reality, such associations can develop when there is a significant time gap between the events to be associated, violating the conditions required for the occurrence of synaptic plasticity. We suggested that the conditions required for the development of synaptic plasticity in the brain can be created if the activity of neural representations is prolonged in time such that the required overlap in time at the level of neural ensembles is achieved. To test this assumption, we recorded magnetoencephalograms from voluntary participants during the development of associations between pseudowords and movements of the four limbs. The results obtained here show that there is indeed a significant prolongation of stimulus-induced auditory-verbal activation when new associations develop. Thus, during the development of an association, conditions can be created in the brain for the development of Hebbian plasticity, even if the associated events are separated in time.
2023
47.
Чернышев, Б. В.; Пульцина, К. И.; Третьякова, В. Д.; Мясникова, А. С.; Прокофьев, А. О.; Козунова, Г. Л.; Строганова, Т. А. (2023). Нейрофизиологические механизмы стратегий использования и исследования при выскофункциональном аутизме: магнитоэнцефалографическое исследование. Гены и Клетки, 18(4), 606-609. https://doi.org/10.17816/gc623327
@article{Chernyshev2023b,
title = {Нейрофизиологические механизмы стратегий использования и исследования при выскофункциональном аутизме: магнитоэнцефалографическое исследование},
author = {Чернышев, Б. В. and Пульцина, К. И. and Третьякова, В. Д. and Мясникова, А. С. and Прокофьев, А. О. and Козунова, Г. Л. and Строганова, Т.А.},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.17816_gc623327.pdf},
doi = {10.17816/gc623327},
issn = {2500-2562},
year = {2023},
date = {2023-12-15},
urldate = {2023-12-15},
journal = {Гены и Клетки},
volume = {18},
number = {4},
pages = {606-609},
abstract = {Нетерпимость к неопределённости и высокую чувствительностью к угрозе неудачи рассматривают как один из факторов, поддерживающих хроническое беспокойство у пациентов с высокофункциональным аутизмом. Мы исследовали, каким образом эти личностные черты у пациентов с аутизмом сказываются на мозговых процессах, обеспечивающих стратегии выбора в вероятностной среде.
21 участник эксперимента от 19 до 46 лет с высокофункциональным аутизмом и высоким уровнем нетерпимости к неопределённости в возрасте и 21 нейротипичный доброволец того же возраста выполняли задачу вероятностного выбора из двух альтернатив, одна из которых приносила денежный выигрыш в 70% случаев, а другая — только в 30% случаев. После каждого выбора испытуемые получали обратную связь, и методом проб и ошибок они обучались предпочтению более выгодного стимула. С этого момента мы рассматривали частые выборы выгодного стимула как следование внутренней ценностной модели, то есть как стратегию использования, а редкие выборы невыгодного стимула — как следование стратегии исследования (которая невыгодна в постоянной среде, но позволяет адаптировать поведение к её неожиданным изменениям). Мы предположили, что характерные различия между группами в активности мозга, отражающей стратегии использования и исследования, проявятся в периоде принятия решения, а также после внутренней оценки поступившей обратной связи о результатах выгодного и невыгодного выбора [1]. Мы анализировали бета-осцилляции (16–30 Гц) в записи магнитоэнцефалограммы. Подавление мощности бета-осцилляций ниже фонового уровня в период времени между предъявлением стимулов и ответом испытуемого рассматривали как показатель активации областей мозга, участвующих в принятии решения о стратегии выбора, а повышение мощности бета-осцилляций после сигнала обратной связи о проигрыше при невыгодном выборе — как отражение работы механизма, закрепляющего внутреннюю ценностную модель применительно к текущей задаче [1]. Мощность корковых источников бета-осцилляций в 448 областях коры больших полушарий оценивали с помощью метода sLoreta на уровне отдельных реализаций. Статистический анализ осуществляли с помощью смешанных линейных моделей (LMM), поправку на множественные сравнения выполняли с помощью метода FDR на число анализируемых областей коры больших полушарий. Анализ был направлен на интервал принятия решения (–900…–300 мс перед моторным действием выбора) и интервал после обратной связи (500–900 мс после начала предъявления обратной связи) [1].
Согласно результатам опросников, участники эксперимента с высокофункциональным аутизмом имели достоверно более низкую терпимость к неопределённости и более высокую нетерпимость к неопределённости по сравнению с нейротипичными испытуемыми.
Исследование принесло два основных результата. Во-первых, при принятии решения уровень активации областей мозга зависел от типа выбора у контрольных испытуемых и испытуемых с аутизмом прямо противоположным образом. Принятие решения о выгодном выборе в сравнении с невыгодным сопровождалось меньшей активацией нижневисочных, теменных и медиальных лобных областей коры у контрольных испытуемых и большей активаций этих зон у испытуемых с расстройствами аутистического спектра. Эти данные указывают на то, что нейротипичные испытуемые при принятии выгодного для них решения тратят меньше ресурсов мозга и испытывают меньше эмоций, чем в случае исследовательского выбора, который, исходя из их прошлого опыта, с высокой вероятностью принесёт неудачу. Напротив, люди с аутизмом расходуют аномально много ресурсов внимания и эмоций при планировании относительно безопасных для них действий, исход которых сулит вероятную (но не гарантированную) выгоду, тогда как угроза высоковероятной неудачи активирует их мозг в меньшей степени.
Во-вторых, внутренняя оценка поступившей обратной связи была связана с различиями между людьми с аутизмом и контрольными испытуемыми в функциональной активности орбитофронтальных и латеральных префронтальных областей коры при исследовательском (невыгодном) выборе. Как и в нашем предыдущим исследовании, у нейротипичных испытуемых наблюдалась сильная бета-синхронизация после отрицательной обратной связи после невыгодного выбора [1]. В отличие от контрольных испытуемых, у испытуемых с расстройствами аутистического спектра отсутствовала синхронизация фронтальных бета-осцилляций после проигрыша в результате невыгодного выбора. Этот факт может означать слабое закрепление внутренней ценностной модели, которое в норме возникает после совпадения прогнозируемого на её основе негативного исхода действия с его реальным результатом [1].
В целом, наше исследование показало, что людей с расстройствами аутистического спектра и крайней нетерпимостью к неопределённости характеризует аномально высокий уровень вовлечения мозговых систем принятия решений в относительно безопасных условиях, гарантирующих высокую вероятность благоприятного исхода планируемого действия. Эта находка проливает свет на причины парадоксального повышения уровня тревоги и вегетативной реактивности у таких людей в ситуациях ожидания награды, которые, в отличие от угрозы наказания, по своей природе не являются аверсивными [2].
1. Chernyshev B.V., Pultsina K.I., Tretyakova V.D., et al. Losses resulting from deliberate exploration trigger beta oscillations in frontal cortex // Frontiers in Neuroscience. 2023. Vol. 17. P. 1152926. doi: 10.3389/fnins.2023.1152926
2. Tanovic E., Gee D.G., Joormann J. Intolerance of uncertainty: Neural and psychophysiological correlates of the perception of uncertainty as threatening // Clinical psychology review. 2018. Vol. 60. P. 87–99. doi: 10.1016/j.cpr.2018.01.001},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Нетерпимость к неопределённости и высокую чувствительностью к угрозе неудачи рассматривают как один из факторов, поддерживающих хроническое беспокойство у пациентов с высокофункциональным аутизмом. Мы исследовали, каким образом эти личностные черты у пациентов с аутизмом сказываются на мозговых процессах, обеспечивающих стратегии выбора в вероятностной среде.
21 участник эксперимента от 19 до 46 лет с высокофункциональным аутизмом и высоким уровнем нетерпимости к неопределённости в возрасте и 21 нейротипичный доброволец того же возраста выполняли задачу вероятностного выбора из двух альтернатив, одна из которых приносила денежный выигрыш в 70% случаев, а другая — только в 30% случаев. После каждого выбора испытуемые получали обратную связь, и методом проб и ошибок они обучались предпочтению более выгодного стимула. С этого момента мы рассматривали частые выборы выгодного стимула как следование внутренней ценностной модели, то есть как стратегию использования, а редкие выборы невыгодного стимула — как следование стратегии исследования (которая невыгодна в постоянной среде, но позволяет адаптировать поведение к её неожиданным изменениям). Мы предположили, что характерные различия между группами в активности мозга, отражающей стратегии использования и исследования, проявятся в периоде принятия решения, а также после внутренней оценки поступившей обратной связи о результатах выгодного и невыгодного выбора [1]. Мы анализировали бета-осцилляции (16–30 Гц) в записи магнитоэнцефалограммы. Подавление мощности бета-осцилляций ниже фонового уровня в период времени между предъявлением стимулов и ответом испытуемого рассматривали как показатель активации областей мозга, участвующих в принятии решения о стратегии выбора, а повышение мощности бета-осцилляций после сигнала обратной связи о проигрыше при невыгодном выборе — как отражение работы механизма, закрепляющего внутреннюю ценностную модель применительно к текущей задаче [1]. Мощность корковых источников бета-осцилляций в 448 областях коры больших полушарий оценивали с помощью метода sLoreta на уровне отдельных реализаций. Статистический анализ осуществляли с помощью смешанных линейных моделей (LMM), поправку на множественные сравнения выполняли с помощью метода FDR на число анализируемых областей коры больших полушарий. Анализ был направлен на интервал принятия решения (–900…–300 мс перед моторным действием выбора) и интервал после обратной связи (500–900 мс после начала предъявления обратной связи) [1].
Согласно результатам опросников, участники эксперимента с высокофункциональным аутизмом имели достоверно более низкую терпимость к неопределённости и более высокую нетерпимость к неопределённости по сравнению с нейротипичными испытуемыми.
Исследование принесло два основных результата. Во-первых, при принятии решения уровень активации областей мозга зависел от типа выбора у контрольных испытуемых и испытуемых с аутизмом прямо противоположным образом. Принятие решения о выгодном выборе в сравнении с невыгодным сопровождалось меньшей активацией нижневисочных, теменных и медиальных лобных областей коры у контрольных испытуемых и большей активаций этих зон у испытуемых с расстройствами аутистического спектра. Эти данные указывают на то, что нейротипичные испытуемые при принятии выгодного для них решения тратят меньше ресурсов мозга и испытывают меньше эмоций, чем в случае исследовательского выбора, который, исходя из их прошлого опыта, с высокой вероятностью принесёт неудачу. Напротив, люди с аутизмом расходуют аномально много ресурсов внимания и эмоций при планировании относительно безопасных для них действий, исход которых сулит вероятную (но не гарантированную) выгоду, тогда как угроза высоковероятной неудачи активирует их мозг в меньшей степени.
Во-вторых, внутренняя оценка поступившей обратной связи была связана с различиями между людьми с аутизмом и контрольными испытуемыми в функциональной активности орбитофронтальных и латеральных префронтальных областей коры при исследовательском (невыгодном) выборе. Как и в нашем предыдущим исследовании, у нейротипичных испытуемых наблюдалась сильная бета-синхронизация после отрицательной обратной связи после невыгодного выбора [1]. В отличие от контрольных испытуемых, у испытуемых с расстройствами аутистического спектра отсутствовала синхронизация фронтальных бета-осцилляций после проигрыша в результате невыгодного выбора. Этот факт может означать слабое закрепление внутренней ценностной модели, которое в норме возникает после совпадения прогнозируемого на её основе негативного исхода действия с его реальным результатом [1].
В целом, наше исследование показало, что людей с расстройствами аутистического спектра и крайней нетерпимостью к неопределённости характеризует аномально высокий уровень вовлечения мозговых систем принятия решений в относительно безопасных условиях, гарантирующих высокую вероятность благоприятного исхода планируемого действия. Эта находка проливает свет на причины парадоксального повышения уровня тревоги и вегетативной реактивности у таких людей в ситуациях ожидания награды, которые, в отличие от угрозы наказания, по своей природе не являются аверсивными [2].
1. Chernyshev B.V., Pultsina K.I., Tretyakova V.D., et al. Losses resulting from deliberate exploration trigger beta oscillations in frontal cortex // Frontiers in Neuroscience. 2023. Vol. 17. P. 1152926. doi: 10.3389/fnins.2023.1152926
2. Tanovic E., Gee D.G., Joormann J. Intolerance of uncertainty: Neural and psychophysiological correlates of the perception of uncertainty as threatening // Clinical psychology review. 2018. Vol. 60. P. 87–99. doi: 10.1016/j.cpr.2018.01.001
21 участник эксперимента от 19 до 46 лет с высокофункциональным аутизмом и высоким уровнем нетерпимости к неопределённости в возрасте и 21 нейротипичный доброволец того же возраста выполняли задачу вероятностного выбора из двух альтернатив, одна из которых приносила денежный выигрыш в 70% случаев, а другая — только в 30% случаев. После каждого выбора испытуемые получали обратную связь, и методом проб и ошибок они обучались предпочтению более выгодного стимула. С этого момента мы рассматривали частые выборы выгодного стимула как следование внутренней ценностной модели, то есть как стратегию использования, а редкие выборы невыгодного стимула — как следование стратегии исследования (которая невыгодна в постоянной среде, но позволяет адаптировать поведение к её неожиданным изменениям). Мы предположили, что характерные различия между группами в активности мозга, отражающей стратегии использования и исследования, проявятся в периоде принятия решения, а также после внутренней оценки поступившей обратной связи о результатах выгодного и невыгодного выбора [1]. Мы анализировали бета-осцилляции (16–30 Гц) в записи магнитоэнцефалограммы. Подавление мощности бета-осцилляций ниже фонового уровня в период времени между предъявлением стимулов и ответом испытуемого рассматривали как показатель активации областей мозга, участвующих в принятии решения о стратегии выбора, а повышение мощности бета-осцилляций после сигнала обратной связи о проигрыше при невыгодном выборе — как отражение работы механизма, закрепляющего внутреннюю ценностную модель применительно к текущей задаче [1]. Мощность корковых источников бета-осцилляций в 448 областях коры больших полушарий оценивали с помощью метода sLoreta на уровне отдельных реализаций. Статистический анализ осуществляли с помощью смешанных линейных моделей (LMM), поправку на множественные сравнения выполняли с помощью метода FDR на число анализируемых областей коры больших полушарий. Анализ был направлен на интервал принятия решения (–900…–300 мс перед моторным действием выбора) и интервал после обратной связи (500–900 мс после начала предъявления обратной связи) [1].
Согласно результатам опросников, участники эксперимента с высокофункциональным аутизмом имели достоверно более низкую терпимость к неопределённости и более высокую нетерпимость к неопределённости по сравнению с нейротипичными испытуемыми.
Исследование принесло два основных результата. Во-первых, при принятии решения уровень активации областей мозга зависел от типа выбора у контрольных испытуемых и испытуемых с аутизмом прямо противоположным образом. Принятие решения о выгодном выборе в сравнении с невыгодным сопровождалось меньшей активацией нижневисочных, теменных и медиальных лобных областей коры у контрольных испытуемых и большей активаций этих зон у испытуемых с расстройствами аутистического спектра. Эти данные указывают на то, что нейротипичные испытуемые при принятии выгодного для них решения тратят меньше ресурсов мозга и испытывают меньше эмоций, чем в случае исследовательского выбора, который, исходя из их прошлого опыта, с высокой вероятностью принесёт неудачу. Напротив, люди с аутизмом расходуют аномально много ресурсов внимания и эмоций при планировании относительно безопасных для них действий, исход которых сулит вероятную (но не гарантированную) выгоду, тогда как угроза высоковероятной неудачи активирует их мозг в меньшей степени.
Во-вторых, внутренняя оценка поступившей обратной связи была связана с различиями между людьми с аутизмом и контрольными испытуемыми в функциональной активности орбитофронтальных и латеральных префронтальных областей коры при исследовательском (невыгодном) выборе. Как и в нашем предыдущим исследовании, у нейротипичных испытуемых наблюдалась сильная бета-синхронизация после отрицательной обратной связи после невыгодного выбора [1]. В отличие от контрольных испытуемых, у испытуемых с расстройствами аутистического спектра отсутствовала синхронизация фронтальных бета-осцилляций после проигрыша в результате невыгодного выбора. Этот факт может означать слабое закрепление внутренней ценностной модели, которое в норме возникает после совпадения прогнозируемого на её основе негативного исхода действия с его реальным результатом [1].
В целом, наше исследование показало, что людей с расстройствами аутистического спектра и крайней нетерпимостью к неопределённости характеризует аномально высокий уровень вовлечения мозговых систем принятия решений в относительно безопасных условиях, гарантирующих высокую вероятность благоприятного исхода планируемого действия. Эта находка проливает свет на причины парадоксального повышения уровня тревоги и вегетативной реактивности у таких людей в ситуациях ожидания награды, которые, в отличие от угрозы наказания, по своей природе не являются аверсивными [2].
1. Chernyshev B.V., Pultsina K.I., Tretyakova V.D., et al. Losses resulting from deliberate exploration trigger beta oscillations in frontal cortex // Frontiers in Neuroscience. 2023. Vol. 17. P. 1152926. doi: 10.3389/fnins.2023.1152926
2. Tanovic E., Gee D.G., Joormann J. Intolerance of uncertainty: Neural and psychophysiological correlates of the perception of uncertainty as threatening // Clinical psychology review. 2018. Vol. 60. P. 87–99. doi: 10.1016/j.cpr.2018.01.001
46.
Orekhova, Elena V.; Fadeev, Kirill A.; Goiaeva, Dzerassa E.; Obukhova, Tatiana S.; Ovsiannikova, Tatiana M.; Prokofyev, Andrey O.; Stroganova, Tatiana A. (2023). Different hemispheric lateralization for periodicity and formant structure of vowels in the auditory cortex and its changes between childhood and adulthood. Cortex, 171, 287-307. https://doi.org/10.1016/j.cortex.2023.10.020
Abstract | PDF (preprint) | BibTeX
@article{Orekhova2024,
title = {Different hemispheric lateralization for periodicity and formant structure of vowels in the auditory cortex and its changes between childhood and adulthood},
author = {Elena V. Orekhova and Kirill A. Fadeev and Dzerassa E. Goiaeva and Tatiana S. Obukhova and Tatiana M. Ovsiannikova and Andrey O. Prokofyev and Tatiana A. Stroganova},
url = {https://www.biorxiv.org/content/10.1101/2022.12.08.519561v2.full.pdf},
doi = {10.1016/j.cortex.2023.10.020},
issn = {0010-9452},
year = {2023},
date = {2023-11-19},
urldate = {2023-11-19},
journal = {Cortex},
volume = {171},
pages = {287-307},
publisher = {Elsevier BV},
abstract = {The spectral formant structure and periodicity pitch are the major features that determine the identity of vowels and the characteristics of the speaker. However, very little is known about how the processing of these features in the auditory cortex changes during development. To address this question, we independently manipulated the periodicity and formant structure of vowels while measuring auditory cortex responses using magnetoencephalography (MEG) in children aged 7–12 years and adults. We analyzed the sustained negative shift of source current associated with these vowel properties, which was present in the auditory cortex in both age groups despite differences in the transient components of the auditory response. In adults, the sustained activation associated with formant structure was lateralized to the left hemisphere early in the auditory processing stream requiring neither attention nor semantic mapping. This lateralization was not yet established in children, in whom the right hemisphere contribution to formant processing was strong and decreased during or after puberty. In contrast to the formant structure, periodicity was associated with a greater response in the right hemisphere in both children and adults. These findings suggest that left-lateralization for the automatic processing of vowel formant structure emerges relatively late in ontogenesis and pose a serious challenge to current theories of hemispheric specialization for speech processing.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The spectral formant structure and periodicity pitch are the major features that determine the identity of vowels and the characteristics of the speaker. However, very little is known about how the processing of these features in the auditory cortex changes during development. To address this question, we independently manipulated the periodicity and formant structure of vowels while measuring auditory cortex responses using magnetoencephalography (MEG) in children aged 7–12 years and adults. We analyzed the sustained negative shift of source current associated with these vowel properties, which was present in the auditory cortex in both age groups despite differences in the transient components of the auditory response. In adults, the sustained activation associated with formant structure was lateralized to the left hemisphere early in the auditory processing stream requiring neither attention nor semantic mapping. This lateralization was not yet established in children, in whom the right hemisphere contribution to formant processing was strong and decreased during or after puberty. In contrast to the formant structure, periodicity was associated with a greater response in the right hemisphere in both children and adults. These findings suggest that left-lateralization for the automatic processing of vowel formant structure emerges relatively late in ontogenesis and pose a serious challenge to current theories of hemispheric specialization for speech processing.
45.
Kozunova, G. L.; Zakirov, F. Kh.; Rytikova, A. M.; Stroganova, T. A.; Chernyshev, B. V. (2023). Neurobiological Factors of Executive Dysfunction in Autism Spectrum Disorders. Neuroscience and Behavioral Physiology, 53(7), 1158-1174. https://doi.org/10.1007/s11055-023-01512-7
@article{Kozunova2023,
title = {Neurobiological Factors of Executive Dysfunction in Autism Spectrum Disorders},
author = {G. L. Kozunova and F. Kh. Zakirov and A. M. Rytikova and T. A. Stroganova and B. V. Chernyshev},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1007_s11055-023-01512-7.pdf},
doi = {10.1007/s11055-023-01512-7},
issn = {1573-899X},
year = {2023},
date = {2023-11-10},
urldate = {2023-11-10},
journal = {Neuroscience and Behavioral Physiology},
volume = {53},
number = {7},
pages = {1158-1174},
publisher = {Springer Science and Business Media LLC},
abstract = {Autism is a developmental disorder characterized by difficulties in social interaction and a tendency to stereotypical behavior. Neuropsychological deficit in executive functions – cognitive flexibility, inhibitory control, working memory, etc. – makes a significant contribution to the development of these symptoms. The key role in these processes is played by the prefrontal and cingulate areas of the cortex, which are regulated by cerebral neuromodulatory systems including cholinergic, noradrenergic, serotonergic, and dopaminergic ergicities. In the early stages of brain development, neuromodulators operate as neurotrophic factors and regulate the balance of arousal and inhibition in the cerebral cortex. The pathogenesis of autism may be associated with impaired metabolism of one or more neuromodulators. The purpose of this review is to consider the role of neuromodulators in the formed and developing brain and the contribution made by neuromodulator imbalance to the development of autism symptoms in children and adults.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Autism is a developmental disorder characterized by difficulties in social interaction and a tendency to stereotypical behavior. Neuropsychological deficit in executive functions – cognitive flexibility, inhibitory control, working memory, etc. – makes a significant contribution to the development of these symptoms. The key role in these processes is played by the prefrontal and cingulate areas of the cortex, which are regulated by cerebral neuromodulatory systems including cholinergic, noradrenergic, serotonergic, and dopaminergic ergicities. In the early stages of brain development, neuromodulators operate as neurotrophic factors and regulate the balance of arousal and inhibition in the cerebral cortex. The pathogenesis of autism may be associated with impaired metabolism of one or more neuromodulators. The purpose of this review is to consider the role of neuromodulators in the formed and developing brain and the contribution made by neuromodulator imbalance to the development of autism symptoms in children and adults.
44.
Чернышев, Б. В.; Павлова, А. А.; Рытикова, А. М.; Буторина, А. В.; Строганова, Т. А. (2023). Продление мозговой активации в ответ на стимул как вероятный механизм ассоциативной пластичности при семантическом научении. Журнал высшей нервной деятельности им. И.П.Павлова, 73(6), 764-784. https://doi.org/10.31857/s0044467723060035
@article{Chernyshev2023,
title = {Продление мозговой активации в ответ на стимул как вероятный механизм ассоциативной пластичности при семантическом научении},
author = {Б.В. Чернышев and А.А. Павлова and А.М. Рытикова and А.В. Буторина and Т.А. Строганова},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.31857_s0044467723060035.pdf},
doi = {10.31857/s0044467723060035},
issn = {0044-4677},
year = {2023},
date = {2023-11-01},
urldate = {2023-11-01},
journal = {Журнал высшей нервной деятельности им. И.П.Павлова},
volume = {73},
number = {6},
pages = {764-784},
publisher = {Российская академия наук},
abstract = {Считается, что запоминание смысла новых слов речи происходит благодаря ассоциативному обучению. Например, именно так слова, обозначающие движения, могут сопоставляться с соответствующими моторными актами. Известно, что синаптическая пластичность в мозге развивается при условии совпадения во времени активности клеточных ансамблей, репрезентирующих ассоциируемые события. Однако в реальности при выработке подобных ассоциаций возможен значительный разрыв во времени между ассоциируемыми событиями, нарушающий условия возникновения синаптической пластичности. Мы предположили, что необходимые условия для развития синаптической пластичности в мозге могут создаваться благодаря тому, что активность нейронных репрезентаций продлевается во времени, и тем самым обеспечивается требуемое перекрытие во времени на уровне нейронных ансамблей. Чтобы проверить это предположение, мы регистрировали магнитоэнцефалограмму у добровольных участников во время выработки ассоциаций между псевдословами и движениями четырьмя конечностями. Результаты исследования показывают, что при выработке новых ассоциаций действительно происходит значимое удлинение слухоречевой активации, вызванной стимулом. Таким образом, во время выработки ассоциации в мозге действительно могут создаваться условия для развития Хеббовской пластичности, даже если ассоциируемые события разнесены во времени.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Считается, что запоминание смысла новых слов речи происходит благодаря ассоциативному обучению. Например, именно так слова, обозначающие движения, могут сопоставляться с соответствующими моторными актами. Известно, что синаптическая пластичность в мозге развивается при условии совпадения во времени активности клеточных ансамблей, репрезентирующих ассоциируемые события. Однако в реальности при выработке подобных ассоциаций возможен значительный разрыв во времени между ассоциируемыми событиями, нарушающий условия возникновения синаптической пластичности. Мы предположили, что необходимые условия для развития синаптической пластичности в мозге могут создаваться благодаря тому, что активность нейронных репрезентаций продлевается во времени, и тем самым обеспечивается требуемое перекрытие во времени на уровне нейронных ансамблей. Чтобы проверить это предположение, мы регистрировали магнитоэнцефалограмму у добровольных участников во время выработки ассоциаций между псевдословами и движениями четырьмя конечностями. Результаты исследования показывают, что при выработке новых ассоциаций действительно происходит значимое удлинение слухоречевой активации, вызванной стимулом. Таким образом, во время выработки ассоциации в мозге действительно могут создаваться условия для развития Хеббовской пластичности, даже если ассоциируемые события разнесены во времени.
43.
Pavlova, Anna; Tyulenev, Nikita; Tretyakova, Vera; Skavronskaya, Valeriya; Nikolaeva, Anastasia; Prokofyev, Andrey; Stroganova, Tatiana; Chernyshev, Boris (2023). Learning of new associations invokes a major change in modulations of cortical beta oscillations in human adults. Psychophysiology, 60, e14284. https://doi.org/10.1111/psyp.14284
@article{Pavlova2023,
title = {Learning of new associations invokes a major change in modulations of cortical beta oscillations in human adults},
author = {Anna Pavlova and Nikita Tyulenev and Vera Tretyakova and Valeriya Skavronskaya and Anastasia Nikolaeva and Andrey Prokofyev and Tatiana Stroganova and Boris Chernyshev},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1111_psyp.14284.pdf},
doi = {10.1111/psyp.14284},
issn = {1469-8986},
year = {2023},
date = {2023-08-00},
urldate = {2023-08-00},
journal = {Psychophysiology},
volume = {60},
issue = {8},
pages = {e14284},
publisher = {Wiley},
abstract = {Large-scale cortical beta (β) oscillations were implicated in the learning processes, but their exact role is debated. We used MEG to explore the dynamics of movement-related β-oscillations while 22 adults learned, through trial and error, novel associations between four auditory pseudowords and movements of four limbs. As learning proceeded, spatial–temporal characteristics of β-oscillations accompanying cue-triggered movements underwent a major transition. Early in learning, widespread suppression of β-power occurred long before movement initiation and sustained throughout the whole behavioral trial. When learning advanced and performance reached asymptote, β-suppression after the initiation of correct motor response was replaced by a rise in β-power mainly in the prefrontal and medial temporal regions of the left hemisphere. This post-decision β-power predicted trial-by-trial response times (RT) at both stages of learning (before and after the rules become familiar), but with different signs of interaction. When a subject just started to acquire associative rules and gradually improved task performance, a decrease in RT correlated with the increase in the post-decision β-band power. When the participants implemented the already acquired rules, faster (more confident) responses were associated with the weaker post-decision β-band synchronization. Our findings suggest that maximal beta activity is pertinent to a distinct stage of learning and may serve to strengthen the newly learned association in a distributed memory network.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Large-scale cortical beta (β) oscillations were implicated in the learning processes, but their exact role is debated. We used MEG to explore the dynamics of movement-related β-oscillations while 22 adults learned, through trial and error, novel associations between four auditory pseudowords and movements of four limbs. As learning proceeded, spatial–temporal characteristics of β-oscillations accompanying cue-triggered movements underwent a major transition. Early in learning, widespread suppression of β-power occurred long before movement initiation and sustained throughout the whole behavioral trial. When learning advanced and performance reached asymptote, β-suppression after the initiation of correct motor response was replaced by a rise in β-power mainly in the prefrontal and medial temporal regions of the left hemisphere. This post-decision β-power predicted trial-by-trial response times (RT) at both stages of learning (before and after the rules become familiar), but with different signs of interaction. When a subject just started to acquire associative rules and gradually improved task performance, a decrease in RT correlated with the increase in the post-decision β-band power. When the participants implemented the already acquired rules, faster (more confident) responses were associated with the weaker post-decision β-band synchronization. Our findings suggest that maximal beta activity is pertinent to a distinct stage of learning and may serve to strengthen the newly learned association in a distributed memory network.
42.
Chernyshev, Boris V.; Pultsina, Kristina I.; Tretyakova, Vera D.; Miasnikova, Aleksandra S.; Prokofyev, Andrey O.; Kozunova, Galina L.; Stroganova, Tatiana A. (2023). Losses resulting from deliberate exploration trigger beta oscillations in frontal cortex. Frontiers in Neuroscience, 17, 1152926. https://doi.org/10.3389/fnins.2023.1152926
@article{Chernyshev2023c,
title = {Losses resulting from deliberate exploration trigger beta oscillations in frontal cortex},
author = {Boris V. Chernyshev and Kristina I. Pultsina and Vera D. Tretyakova and Aleksandra S. Miasnikova and Andrey O. Prokofyev and Galina L. Kozunova and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnins.2023.1152926.pdf},
doi = {10.3389/fnins.2023.1152926},
issn = {1662-453X},
year = {2023},
date = {2023-05-11},
urldate = {2023-05-11},
journal = {Frontiers in Neuroscience},
volume = {17},
pages = {1152926},
publisher = {Frontiers Media SA},
abstract = {We examined the neural signature of directed exploration by contrasting MEG beta (16–30 Hz) power changes between disadvantageous and advantageous choices in the two-choice probabilistic reward task. We analyzed the choices made after the participants have learned the probabilistic contingency between choices and their outcomes, i.e., acquired the inner model of choice values. Therefore, rare disadvantageous choices might serve explorative, environment-probing purposes. The study brought two main findings. Firstly, decision making leading to disadvantageous choices took more time and evidenced greater large-scale suppression of beta oscillations than its advantageous alternative. Additional neural resources recruited during disadvantageous decisions strongly suggest their deliberately explorative nature. Secondly, an outcome of disadvantageous and advantageous choices had qualitatively different impact on feedback-related beta oscillations. After the disadvantageous choices, only losses—but not gains—were followed by late beta synchronization in frontal cortex. Our results are consistent with the role of frontal beta oscillations in the stabilization of neural representations for selected behavioral rule when explorative strategy conflicts with value-based behavior. Punishment for explorative choice being congruent with its low value in the reward history is more likely to strengthen, through punishment-related beta oscillations, the representation of exploitative choices consistent with the inner utility model.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We examined the neural signature of directed exploration by contrasting MEG beta (16–30 Hz) power changes between disadvantageous and advantageous choices in the two-choice probabilistic reward task. We analyzed the choices made after the participants have learned the probabilistic contingency between choices and their outcomes, i.e., acquired the inner model of choice values. Therefore, rare disadvantageous choices might serve explorative, environment-probing purposes. The study brought two main findings. Firstly, decision making leading to disadvantageous choices took more time and evidenced greater large-scale suppression of beta oscillations than its advantageous alternative. Additional neural resources recruited during disadvantageous decisions strongly suggest their deliberately explorative nature. Secondly, an outcome of disadvantageous and advantageous choices had qualitatively different impact on feedback-related beta oscillations. After the disadvantageous choices, only losses—but not gains—were followed by late beta synchronization in frontal cortex. Our results are consistent with the role of frontal beta oscillations in the stabilization of neural representations for selected behavioral rule when explorative strategy conflicts with value-based behavior. Punishment for explorative choice being congruent with its low value in the reward history is more likely to strengthen, through punishment-related beta oscillations, the representation of exploitative choices consistent with the inner utility model.
41.
Фадеев, К. А.; Гояева, Д. Э.; Обухова, Т. С.; Овсянникова, Т. М.; Шведовский, Е. Ф.; Николаева, А. Ю.; Давыдова, Е. Ю.; Строганова, Т. А.; Орехова, Е. В. (2023). Трудности с восприятием речи на фоне шума у детей с расстройствами аутистического спектра не связаны с уровнем их интеллекта. Клиническая и специальная психология, 12(1), 180-212. https://doi.org/10.17759/cpse.2023120108
@article{Fadeev2023,
title = {Трудности с восприятием речи на фоне шума у детей с расстройствами аутистического спектра не связаны с уровнем их интеллекта},
author = {Фадеев, К.А. and Гояева, Д.Э. and Обухова, Т.С. and Овсянникова, Т.М. and Шведовский, Е.Ф. and Николаева, А.Ю. and Давыдова, Е.Ю. and Строганова, Т.А. and Орехова, Е.В.},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.17759_cpse.2023120108.pdf},
doi = {10.17759/cpse.2023120108},
issn = {2304-0394},
year = {2023},
date = {2023-04-10},
urldate = {2023-04-10},
journal = {Клиническая и специальная психология},
volume = {12},
number = {1},
pages = {180-212},
publisher = {Московский государственный психолого-педагогический университет},
abstract = {Известно, что детям с расстройствами аутистического спектра (РАС) сложнее, чем типично развивающимся сверстникам, понимать речь в шумной обстановке. В основе такого нарушения могут лежать снижение помехоустойчивости и/или трудности интеграции фрагментов речи, расслышанных в интервалах, которые имеются в окружающих шумах. Мы исследовали роль этих факторов в восприятии слов на фоне шума у детей с РАС с широким спектром интеллектуальных способностей. Выборку составили 42 ребенка с РАС и 38 типично развивающихся детей 7–12 лет. Детям предлагалось повторять двусложные слова, предъявляемые на фоне шума. Использовалось два типа маскировки: стационарный шум и шум, модулированный по амплитуде. Уровень интеллекта оценивался с помощью Батареи тестов Кауфмана для детей (KABC-II). Результаты свидетельствуют о том, что дети с РАС хуже, чем типично развивающиеся дети, распознавали слова на фоне стационарного шума, т.е. имели сниженную помехоустойчивость. Даже после поправки на помехоустойчивость, наличие интервалов сниженной интенсивности в шуме, модулированном по амплитуде, в меньшей степени улучшало распознавание слов у детей с РАС, чем у типично развивающихся детей (F(1,75)=18,57, p<0,001). Ни успешность восприятия слов на фоне стационарного шума, ни способность использовать для распознавания интервалы низкой интенсивности шума не коррелировали у детей с РАС с уровнем интеллекта (коэффициент Спирмена, все p>0,80). Трудности восприятия зашумленной речи у детей с РАС не зависят напрямую от уровня их когнитивных способностей и связаны как с низкой помехоустойчивостью, так и слабыми возможностями временной интеграции фонем в слова.
Портал психологических изданий PsyJournals.ru — https://psyjournals.ru/journals/cpse/archive/2023_n1/Fadeev_et_al [Трудности с восприятием речи на фоне шума у детей с расстройствами аутистического спектра не связаны с уровнем их интеллекта // Клиническая и специальная психология — 2023. Том 12. № 1]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Известно, что детям с расстройствами аутистического спектра (РАС) сложнее, чем типично развивающимся сверстникам, понимать речь в шумной обстановке. В основе такого нарушения могут лежать снижение помехоустойчивости и/или трудности интеграции фрагментов речи, расслышанных в интервалах, которые имеются в окружающих шумах. Мы исследовали роль этих факторов в восприятии слов на фоне шума у детей с РАС с широким спектром интеллектуальных способностей. Выборку составили 42 ребенка с РАС и 38 типично развивающихся детей 7–12 лет. Детям предлагалось повторять двусложные слова, предъявляемые на фоне шума. Использовалось два типа маскировки: стационарный шум и шум, модулированный по амплитуде. Уровень интеллекта оценивался с помощью Батареи тестов Кауфмана для детей (KABC-II). Результаты свидетельствуют о том, что дети с РАС хуже, чем типично развивающиеся дети, распознавали слова на фоне стационарного шума, т.е. имели сниженную помехоустойчивость. Даже после поправки на помехоустойчивость, наличие интервалов сниженной интенсивности в шуме, модулированном по амплитуде, в меньшей степени улучшало распознавание слов у детей с РАС, чем у типично развивающихся детей (F(1,75)=18,57, p<0,001). Ни успешность восприятия слов на фоне стационарного шума, ни способность использовать для распознавания интервалы низкой интенсивности шума не коррелировали у детей с РАС с уровнем интеллекта (коэффициент Спирмена, все p>0,80). Трудности восприятия зашумленной речи у детей с РАС не зависят напрямую от уровня их когнитивных способностей и связаны как с низкой помехоустойчивостью, так и слабыми возможностями временной интеграции фонем в слова.
Портал психологических изданий PsyJournals.ru — https://psyjournals.ru/journals/cpse/archive/2023_n1/Fadeev_et_al [Трудности с восприятием речи на фоне шума у детей с расстройствами аутистического спектра не связаны с уровнем их интеллекта // Клиническая и специальная психология — 2023. Том 12. № 1]
Портал психологических изданий PsyJournals.ru — https://psyjournals.ru/journals/cpse/archive/2023_n1/Fadeev_et_al [Трудности с восприятием речи на фоне шума у детей с расстройствами аутистического спектра не связаны с уровнем их интеллекта // Клиническая и специальная психология — 2023. Том 12. № 1]
40.
Козунова, Г. Л.; Закиров, Ф. Х.; Рытикова, А. М.; Строганова, Т. А.; Чернышев, Б. В. (2023). Нейробиологические факторы нарушения исполнительных функций при аутизме. Журнал высшей нервной деятельности им. И. П. Павлова, 73(2), 147-172. https://doi.org/10.31857/s0044467723020077
@article{Kozunova2023b,
title = {Нейробиологические факторы нарушения исполнительных функций при аутизме},
author = {Козунова, Г.Л. and Закиров, Ф.Х. and Рытикова, А.М. and Строганова, Т.А. and Чернышев, Б.В.},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.31857_s0044467723020077.pdf},
doi = {10.31857/s0044467723020077},
issn = {0044-4677},
year = {2023},
date = {2023-03-01},
urldate = {2023-03-01},
journal = {Журнал высшей нервной деятельности им. И. П. Павлова},
volume = {73},
number = {2},
pages = {147-172},
publisher = {Российская академия наук},
abstract = {Аутизм является нарушением психического развития, характеризующимся трудностями социального взаимодействия и склонностью к стереотипному поведению. Значительный вклад в развитие этих симптомов вносит нейропсихологический дефицит исполнительных функций – когнитивной гибкости, тормозного контроля, рабочей памяти и др. Ключевую роль в этих процессах играют префронтальная и поясная кора, которые регулируются нейромодуляторными системами мозга, включая холинергическую, норадренергическую, серотонинергическую и дофаминергическую. На ранних этапах развития мозга нейромодуляторы выполняют роль нейротрофических факторов и регулируют баланс возбуждения и торможения в коре больших полушарий. Патогенез аутизма может быть связан с нарушением метаболизма одного или нескольких нейромодуляторов. Цель настоящего обзора состоит в том, чтобы рассмотреть роль нейромодуляторов в сформированном и развивающемся мозге и вклад, который вносит их дисбаланс в развитие симптомов аутизма у детей и взрослых.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Аутизм является нарушением психического развития, характеризующимся трудностями социального взаимодействия и склонностью к стереотипному поведению. Значительный вклад в развитие этих симптомов вносит нейропсихологический дефицит исполнительных функций – когнитивной гибкости, тормозного контроля, рабочей памяти и др. Ключевую роль в этих процессах играют префронтальная и поясная кора, которые регулируются нейромодуляторными системами мозга, включая холинергическую, норадренергическую, серотонинергическую и дофаминергическую. На ранних этапах развития мозга нейромодуляторы выполняют роль нейротрофических факторов и регулируют баланс возбуждения и торможения в коре больших полушарий. Патогенез аутизма может быть связан с нарушением метаболизма одного или нескольких нейромодуляторов. Цель настоящего обзора состоит в том, чтобы рассмотреть роль нейромодуляторов в сформированном и развивающемся мозге и вклад, который вносит их дисбаланс в развитие симптомов аутизма у детей и взрослых.
39.
Orekhova, Elena V.; Manyukhina, Viktoriya O.; Galuta, Ilia A.; Prokofyev, Andrey O.; Goiaeva, Dzerassa E.; Obukhova, Tatiana S.; Fadeev, Kirill A.; Schneiderman, Justin F.; Stroganova, Tatiana A. (2023). Gamma oscillations point to the role of primary visual cortex in atypical motion processing in autism. PLoS ONE, 18(2), e0281531. https://doi.org/10.1371/journal.pone.0281531
@article{Orekhova2023,
title = {Gamma oscillations point to the role of primary visual cortex in atypical motion processing in autism},
author = {Elena V. Orekhova and Viktoriya O. Manyukhina and Ilia A. Galuta and Andrey O. Prokofyev and Dzerassa E. Goiaeva and Tatiana S. Obukhova and Kirill A. Fadeev and Justin F. Schneiderman and Tatiana A. Stroganova},
editor = {Mehdi Adibi},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1371_journal.pone.0281531.pdf},
doi = {10.1371/journal.pone.0281531},
issn = {1932-6203},
year = {2023},
date = {2023-02-13},
urldate = {2023-02-13},
journal = {PLoS ONE},
volume = {18},
number = {2},
pages = {e0281531},
publisher = {Public Library of Science (PLoS)},
abstract = {Neurophysiological studies suggest that abnormal neural inhibition may explain a range of sensory processing differences in autism spectrum disorders (ASD). In particular, the impaired ability of people with ASD to visually discriminate the motion direction of small-size objects and their reduced perceptual suppression of background-like visual motion may stem from deficient surround inhibition within the primary visual cortex (V1) and/or its atypical top-down modulation by higher-tier cortical areas. In this study, we estimate the contribution of abnormal surround inhibition to the motion-processing deficit in ASD. For this purpose, we used a putative correlate of surround inhibition–suppression of the magnetoencephalographic (MEG) gamma response (GR) caused by an increase in the drift rate of a large annular high-contrast grating. The motion direction discrimination thresholds for the gratings of different angular sizes (1° and 12°) were assessed in a separate psychophysical paradigm. The MEG data were collected in 42 boys with ASD and 37 typically developing (TD) boys aged 7–15 years. Psychophysical data were available in 33 and 34 of these participants, respectively. The results showed that the GR suppression in V1 was reduced in boys with ASD, while their ability to detect the direction of motion was compromised only in the case of small stimuli. In TD boys, the GR suppression directly correlated with perceptual suppression caused by increasing stimulus size, thus suggesting the role of the top-down modulations of V1 in surround inhibition. In ASD, weaker GR suppression was associated with the poor directional sensitivity to small stimuli, but not with perceptual suppression. These results strongly suggest that a local inhibitory deficit in V1 plays an important role in the reduction of directional sensitivity in ASD and that this perceptual deficit cannot be explained exclusively by atypical top-down modulation of V1 by higher-tier cortical areas.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Neurophysiological studies suggest that abnormal neural inhibition may explain a range of sensory processing differences in autism spectrum disorders (ASD). In particular, the impaired ability of people with ASD to visually discriminate the motion direction of small-size objects and their reduced perceptual suppression of background-like visual motion may stem from deficient surround inhibition within the primary visual cortex (V1) and/or its atypical top-down modulation by higher-tier cortical areas. In this study, we estimate the contribution of abnormal surround inhibition to the motion-processing deficit in ASD. For this purpose, we used a putative correlate of surround inhibition–suppression of the magnetoencephalographic (MEG) gamma response (GR) caused by an increase in the drift rate of a large annular high-contrast grating. The motion direction discrimination thresholds for the gratings of different angular sizes (1° and 12°) were assessed in a separate psychophysical paradigm. The MEG data were collected in 42 boys with ASD and 37 typically developing (TD) boys aged 7–15 years. Psychophysical data were available in 33 and 34 of these participants, respectively. The results showed that the GR suppression in V1 was reduced in boys with ASD, while their ability to detect the direction of motion was compromised only in the case of small stimuli. In TD boys, the GR suppression directly correlated with perceptual suppression caused by increasing stimulus size, thus suggesting the role of the top-down modulations of V1 in surround inhibition. In ASD, weaker GR suppression was associated with the poor directional sensitivity to small stimuli, but not with perceptual suppression. These results strongly suggest that a local inhibitory deficit in V1 plays an important role in the reduction of directional sensitivity in ASD and that this perceptual deficit cannot be explained exclusively by atypical top-down modulation of V1 by higher-tier cortical areas.
2022
38.
Manyukhina, Viktoriya O.; Orekhova, Elena V.; Prokofyev, Andrey O.; Obukhova, Tatiana S.; Stroganova, Tatiana A. (2022). Altered visual cortex excitability in premenstrual dysphoric disorder: Evidence from magnetoencephalographic gamma oscillations and perceptual suppression. PLoS ONE, 17(12), e0279868. https://doi.org/10.1371/journal.pone.0279868
@article{Manyukhina2022,
title = {Altered visual cortex excitability in premenstrual dysphoric disorder: Evidence from magnetoencephalographic gamma oscillations and perceptual suppression},
author = {Viktoriya O. Manyukhina and Elena V. Orekhova and Andrey O. Prokofyev and Tatiana S. Obukhova and Tatiana A. Stroganova},
editor = {Thiago P. Fernandes},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1371_journal.pone.0279868.pdf},
doi = {10.1371/journal.pone.0279868},
issn = {1932-6203},
year = {2022},
date = {2022-12-30},
urldate = {2022-12-30},
journal = {PLoS ONE},
volume = {17},
number = {12},
pages = {e0279868},
publisher = {Public Library of Science (PLoS)},
abstract = {Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by extreme mood shifts during the luteal phase of the menstrual cycle (MC) due to abnormal sensitivity to neurosteroids and unbalanced neural excitation/inhibition (E/I) ratio. We hypothesized that in women with PMDD in the luteal phase, these factors would alter the frequency of magnetoencephalographic visual gamma oscillations, affect modulation of their power by excitatory drive, and decrease perceptual spatial suppression. Women with PMDD and control women were examined twice–during the follicular and luteal phases of their MC. We recorded visual gamma response (GR) while modulating the excitatory drive by increasing the drift rate of the high-contrast grating (static, ‘slow’, ‘medium’, and ‘fast’). Contrary to our expectations, GR frequency was not affected in women with PMDD in either phase of the MC. GR power suppression, which is normally associated with a switch from the ‘optimal’ for GR slow drift rate to the medium drift rate, was reduced in women with PMDD and was the only GR parameter that distinguished them from control participants specifically in the luteal phase and predicted severity of their premenstrual symptoms. Over and above the atypical luteal GR suppression, in both phases of the MC women with PMDD had abnormally strong GR facilitation caused by a switch from the ‘suboptimal’ static to the ‘optimal’ slow drift rate. Perceptual spatial suppression did not differ between the groups but decreased from the follicular to the luteal phase only in PMDD women. The atypical modulation of GR power suggests that neuronal excitability in the visual cortex is constitutively elevated in PMDD and that this E/I imbalance is further exacerbated during the luteal phase. However, the unaltered GR frequency does not support the hypothesis of inhibitory neuron dysfunction in PMDD.
},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by extreme mood shifts during the luteal phase of the menstrual cycle (MC) due to abnormal sensitivity to neurosteroids and unbalanced neural excitation/inhibition (E/I) ratio. We hypothesized that in women with PMDD in the luteal phase, these factors would alter the frequency of magnetoencephalographic visual gamma oscillations, affect modulation of their power by excitatory drive, and decrease perceptual spatial suppression. Women with PMDD and control women were examined twice–during the follicular and luteal phases of their MC. We recorded visual gamma response (GR) while modulating the excitatory drive by increasing the drift rate of the high-contrast grating (static, ‘slow’, ‘medium’, and ‘fast’). Contrary to our expectations, GR frequency was not affected in women with PMDD in either phase of the MC. GR power suppression, which is normally associated with a switch from the ‘optimal’ for GR slow drift rate to the medium drift rate, was reduced in women with PMDD and was the only GR parameter that distinguished them from control participants specifically in the luteal phase and predicted severity of their premenstrual symptoms. Over and above the atypical luteal GR suppression, in both phases of the MC women with PMDD had abnormally strong GR facilitation caused by a switch from the ‘suboptimal’ static to the ‘optimal’ slow drift rate. Perceptual spatial suppression did not differ between the groups but decreased from the follicular to the luteal phase only in PMDD women. The atypical modulation of GR power suggests that neuronal excitability in the visual cortex is constitutively elevated in PMDD and that this E/I imbalance is further exacerbated during the luteal phase. However, the unaltered GR frequency does not support the hypothesis of inhibitory neuron dysfunction in PMDD.
37.
Козунова, Г. Л.; Новиков, А. Ю.; Строганова, Т. А.; Чернышев, Б. В. (2022). Нетерпимость к неопределенности и трудности принятия решений у взрослых людей с высокофункциональным аутизмом. Клиническая и специальная психология, 11(4), 30-69. https://doi.org/10.17759/cpse.2022110402
@article{Kozunova2022,
title = {Нетерпимость к неопределенности и трудности принятия решений у взрослых людей с высокофункциональным аутизмом},
author = {Козунова, Г.Л. and Новиков, А.Ю. and Строганова, Т.А. and Чернышев, Б.В.},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.17759_cpse.2022110402.pdf},
doi = {10.17759/cpse.2022110402},
issn = {2304-0394},
year = {2022},
date = {2022-12-17},
urldate = {2022-12-17},
journal = {Клиническая и специальная психология},
volume = {11},
number = {4},
pages = {30-69},
publisher = {Московский государственный психолого-педагогический университет},
abstract = {Взрослые люди с высокофункциональным аутизмом испытывают трудности с принятием решений в условиях неполноты и неоднозначности информации, в частности, в контексте социального взаимодействия. Необходимость быстрого ответа или отступления от привычного распорядка вызывает у них чрезмерную тревогу, ограничивающую их социальную и профессиональную активность. Попытки замаскировать для окружающих свою консервативность являются одним из факторов риска по развитию у них коморбидной депрессии. С другой стороны, стремление к постоянству и ясности может давать людям с аутизмом преимущества при длительном выполнении монотонных задач. Цель настоящего обзора состоит в том, чтобы рассмотреть эти симптомы в рамках подхода прогностического кодирования информации. Данные ряда экспериментов свидетельствуют о том, что у испытуемых с аутизмом затруднен процесс прогнозирования последствий на основе обобщенного опыта своего взаимодействия с окружающей средой, а также обновления ожиданий по мере поступления новых свидетельств. Можно предполагать, что эти особенности анализа и прагматической оценки информации лежат в основе характерной для большинства людей с аутизмом нетерпимости к неопределенности и избеганию новизны.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Взрослые люди с высокофункциональным аутизмом испытывают трудности с принятием решений в условиях неполноты и неоднозначности информации, в частности, в контексте социального взаимодействия. Необходимость быстрого ответа или отступления от привычного распорядка вызывает у них чрезмерную тревогу, ограничивающую их социальную и профессиональную активность. Попытки замаскировать для окружающих свою консервативность являются одним из факторов риска по развитию у них коморбидной депрессии. С другой стороны, стремление к постоянству и ясности может давать людям с аутизмом преимущества при длительном выполнении монотонных задач. Цель настоящего обзора состоит в том, чтобы рассмотреть эти симптомы в рамках подхода прогностического кодирования информации. Данные ряда экспериментов свидетельствуют о том, что у испытуемых с аутизмом затруднен процесс прогнозирования последствий на основе обобщенного опыта своего взаимодействия с окружающей средой, а также обновления ожиданий по мере поступления новых свидетельств. Можно предполагать, что эти особенности анализа и прагматической оценки информации лежат в основе характерной для большинства людей с аутизмом нетерпимости к неопределенности и избеганию новизны.
36.
Chirkov, Valerii; Kryuchkova, Anna; Koptelova, Alexandra; Stroganova, Tatiana; Kuznetsova, Alexandra; Kleeva, Daria; Ossadtchi, Alexei; Fedele, Tommaso (2022). Data-driven approach for the delineation of the irritative zone in epilepsy in MEG. PLoS ONE, 17(10), e0275063. https://doi.org/10.1371/journal.pone.0275063
@article{Chirkov2022,
title = {Data-driven approach for the delineation of the irritative zone in epilepsy in MEG},
author = {Valerii Chirkov and Anna Kryuchkova and Alexandra Koptelova and Tatiana Stroganova and Alexandra Kuznetsova and Daria Kleeva and Alexei Ossadtchi and Tommaso Fedele},
editor = {Gennady S. Cymbalyuk},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1371_journal.pone.0275063.pdf},
doi = {10.1371/journal.pone.0275063},
issn = {1932-6203},
year = {2022},
date = {2022-10-25},
urldate = {2022-10-25},
journal = {PLoS ONE},
volume = {17},
number = {10},
pages = {e0275063},
publisher = {Public Library of Science (PLoS)},
abstract = {The reliable identification of the irritative zone (IZ) is a prerequisite for the correct clinical evaluation of medically refractory patients affected by epilepsy. Given the complexity of MEG data, visual analysis of epileptiform neurophysiological activity is highly time consuming and might leave clinically relevant information undetected. We recorded and analyzed the interictal activity from seven patients affected by epilepsy (Vectorview Neuromag), who successfully underwent epilepsy surgery (Engel > = II). We visually marked and localized characteristic epileptiform activity (VIS). We implemented a two-stage pipeline for the detection of interictal spikes and the delineation of the IZ. First, we detected candidate events from peaky ICA components, and then clustered events around spatio-temporal patterns identified by convolutional sparse coding. We used the average of clustered events to create IZ maps computed at the amplitude peak (PEAK), and at the 50% of the peak ascending slope (SLOPE). We validated our approach by computing the distance of the estimated IZ (VIS, SLOPE and PEAK) from the border of the surgically resected area (RA). We identified 25 spatiotemporal patterns mimicking the underlying interictal activity (3.6 clusters/patient). Each cluster was populated on average by 22.1 [15.0–31.0] spikes. The predicted IZ maps had an average distance from the resection margin of 8.4 ± 9.3 mm for visual analysis, 12.0 ± 16.5 mm for SLOPE and 22.7 ±. 16.4 mm for PEAK. The consideration of the source spread at the ascending slope provided an IZ closer to RA and resembled the analysis of an expert observer. We validated here the performance of a data-driven approach for the automated detection of interictal spikes and delineation of the IZ. This computational framework provides the basis for reproducible and bias-free analysis of MEG recordings in epilepsy.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The reliable identification of the irritative zone (IZ) is a prerequisite for the correct clinical evaluation of medically refractory patients affected by epilepsy. Given the complexity of MEG data, visual analysis of epileptiform neurophysiological activity is highly time consuming and might leave clinically relevant information undetected. We recorded and analyzed the interictal activity from seven patients affected by epilepsy (Vectorview Neuromag), who successfully underwent epilepsy surgery (Engel > = II). We visually marked and localized characteristic epileptiform activity (VIS). We implemented a two-stage pipeline for the detection of interictal spikes and the delineation of the IZ. First, we detected candidate events from peaky ICA components, and then clustered events around spatio-temporal patterns identified by convolutional sparse coding. We used the average of clustered events to create IZ maps computed at the amplitude peak (PEAK), and at the 50% of the peak ascending slope (SLOPE). We validated our approach by computing the distance of the estimated IZ (VIS, SLOPE and PEAK) from the border of the surgically resected area (RA). We identified 25 spatiotemporal patterns mimicking the underlying interictal activity (3.6 clusters/patient). Each cluster was populated on average by 22.1 [15.0–31.0] spikes. The predicted IZ maps had an average distance from the resection margin of 8.4 ± 9.3 mm for visual analysis, 12.0 ± 16.5 mm for SLOPE and 22.7 ±. 16.4 mm for PEAK. The consideration of the source spread at the ascending slope provided an IZ closer to RA and resembled the analysis of an expert observer. We validated here the performance of a data-driven approach for the automated detection of interictal spikes and delineation of the IZ. This computational framework provides the basis for reproducible and bias-free analysis of MEG recordings in epilepsy.
35.
Vander, Tatiana; Stroganova, Tatiana; Doufish, Diya; Eliashiv, Dawn; Gilboa, Tal; Medvedovsky, Mordekhay; Ekstein, Dana (2022). What is the optimal duration of home-video-EEG monitoring for patients with <1 seizure per day? A simulation study. Frontiers in Neurology, 13, 938294. https://doi.org/10.3389/fneur.2022.938294
@article{Vander2022,
title = {What is the optimal duration of home-video-EEG monitoring for patients with <1 seizure per day? A simulation study},
author = {Tatiana Vander and Tatiana Stroganova and Diya Doufish and Dawn Eliashiv and Tal Gilboa and Mordekhay Medvedovsky and Dana Ekstein},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fneur.2022.938294.pdf},
doi = {10.3389/fneur.2022.938294},
issn = {1664-2295},
year = {2022},
date = {2022-08-22},
urldate = {2022-08-22},
journal = {Frontiers in Neurology},
volume = {13},
pages = {938294},
publisher = {Frontiers Media SA},
abstract = {Ambulatory “at home” video-EEG monitoring (HVEM) may offer a more cost-effective and accessible option as compared to traditional inpatient admissions to epilepsy monitoring units. However, home monitoring may not allow for safe tapering of anti-seizure medications (ASM). As a result, longer periods of monitoring may be necessary to capture a sufficient number of the patients' stereotypic seizures. We aimed to quantitatively estimate the necessary length of HVEM corresponding to various diagnostic scenarios in clinical practice. Using available seizure frequency statistics, we estimated the HVEM duration required to capture one, three, or five seizures on different days, by simulating 100,000 annual time-courses of seizure occurrence in adults and children with more than one and <30 seizures per month (89% of adults and 85% of children). We found that the durations of HVEM needed to record 1, 3, or 5 seizures in 80% of children were 2, 5, and 8 weeks (median 2, 12, and 21 days), respectively, and significantly longer in adults −2, 6, and 10 weeks (median 3, 14, and 26 days; p < 10−10 for all comparisons). Thus, longer HVEM than currently used is needed for expanding its clinical value from diagnosis of nonepileptic or very frequent epileptic events to a presurgical tool for patients with drug-resistant epilepsy. Technical developments and further studies are warranted.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ambulatory “at home” video-EEG monitoring (HVEM) may offer a more cost-effective and accessible option as compared to traditional inpatient admissions to epilepsy monitoring units. However, home monitoring may not allow for safe tapering of anti-seizure medications (ASM). As a result, longer periods of monitoring may be necessary to capture a sufficient number of the patients' stereotypic seizures. We aimed to quantitatively estimate the necessary length of HVEM corresponding to various diagnostic scenarios in clinical practice. Using available seizure frequency statistics, we estimated the HVEM duration required to capture one, three, or five seizures on different days, by simulating 100,000 annual time-courses of seizure occurrence in adults and children with more than one and <30 seizures per month (89% of adults and 85% of children). We found that the durations of HVEM needed to record 1, 3, or 5 seizures in 80% of children were 2, 5, and 8 weeks (median 2, 12, and 21 days), respectively, and significantly longer in adults −2, 6, and 10 weeks (median 3, 14, and 26 days; p < 10−10 for all comparisons). Thus, longer HVEM than currently used is needed for expanding its clinical value from diagnosis of nonepileptic or very frequent epileptic events to a presurgical tool for patients with drug-resistant epilepsy. Technical developments and further studies are warranted.
34.
Stroganova, T. A.; Komarov, K. S.; Goiaeva, D. E.; Obukhova, T. S.; Ovsiannikova, T. M.; Prokofyev, A. O.; Orekhova, E. V. (2022). Effects of the Periodicity and Vowelness of Sounds on Auditory Cortex Responses in Children. Neuroscience and Behavioral Physiology, 52(3), 395-404. https://doi.org/10.1007/s11055-022-01253-z
@article{Stroganova2022,
title = {Effects of the Periodicity and Vowelness of Sounds on Auditory Cortex Responses in Children},
author = {T. A. Stroganova and K. S. Komarov and D. E. Goiaeva and T. S. Obukhova and T. M. Ovsiannikova and A. O. Prokofyev and E. V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1007_s11055-022-01253-z.pdf},
doi = {10.1007/s11055-022-01253-z},
issn = {1573-899X},
year = {2022},
date = {2022-06-07},
urldate = {2022-06-07},
journal = {Neuroscience and Behavioral Physiology},
volume = {52},
number = {3},
pages = {395-404},
publisher = {Springer Science and Business Media LLC},
abstract = {The mechanisms of the human brain decoding speech sounds are of fundamental and applied interest in many areas of neuroscience. This study addresses the roles of periodicity and the speech nature (fixed formant structure) of vowel sounds in modulating auditory cortex activity in typically developing children. We proposed that both of these characteristics are typical of the vowel sounds of speech and that they are processed by different neural networks in the auditory cortex. To test this hypothesis, we constructed a set of acoustic stimuli by manipulating their periodicity and vowelness separately and used magnetoencephalography combined with individual models of the cortical surface to evaluate the cortical topography of the sources of auditory cortex responses and their strengths. The cohort consisted of nine typically developing children aged 7–12 years. We found that early auditory cortex responses (50–150 msec after stimulus onset) were highly sensitive to both the periodicity and vowelness of sounds, with independent tuning of neural networks to each of these properties of speech sounds. Differences in the locations, time dynamics, and hemisphere asymmetry of these differential responses indicated that “sound vowelness zones” in the temporal cortex constitute the earliest level in the speech information processing hierarchy at which processing of the acoustic properties of a periodic signal is transformed into decoding of speech sounds. These results allow the specific features and roles of possible impairments to the processing of the low-level properties of speech sounds and difficulties in speech perception in children with pervasive developmental disorders to be evaluated.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The mechanisms of the human brain decoding speech sounds are of fundamental and applied interest in many areas of neuroscience. This study addresses the roles of periodicity and the speech nature (fixed formant structure) of vowel sounds in modulating auditory cortex activity in typically developing children. We proposed that both of these characteristics are typical of the vowel sounds of speech and that they are processed by different neural networks in the auditory cortex. To test this hypothesis, we constructed a set of acoustic stimuli by manipulating their periodicity and vowelness separately and used magnetoencephalography combined with individual models of the cortical surface to evaluate the cortical topography of the sources of auditory cortex responses and their strengths. The cohort consisted of nine typically developing children aged 7–12 years. We found that early auditory cortex responses (50–150 msec after stimulus onset) were highly sensitive to both the periodicity and vowelness of sounds, with independent tuning of neural networks to each of these properties of speech sounds. Differences in the locations, time dynamics, and hemisphere asymmetry of these differential responses indicated that “sound vowelness zones” in the temporal cortex constitute the earliest level in the speech information processing hierarchy at which processing of the acoustic properties of a periodic signal is transformed into decoding of speech sounds. These results allow the specific features and roles of possible impairments to the processing of the low-level properties of speech sounds and difficulties in speech perception in children with pervasive developmental disorders to be evaluated.
33.
Manyukhina, Viktoriya O.; Prokofyev, Andrey O.; Galuta, Ilia A.; Goiaeva, Dzerassa E.; Obukhova, Tatiana S.; Schneiderman, Justin F.; Altukhov, Dmitrii I.; Stroganova, Tatiana A.; Orekhova, Elena V. (2022). Globally elevated excitation–inhibition ratio in children with autism spectrum disorder and below-average intelligence. Molecular Autism, 13(1). https://doi.org/10.1186/s13229-022-00498-2
@article{Manyukhina2022b,
title = {Globally elevated excitation–inhibition ratio in children with autism spectrum disorder and below-average intelligence},
author = {Viktoriya O. Manyukhina and Andrey O. Prokofyev and Ilia A. Galuta and Dzerassa E. Goiaeva and Tatiana S. Obukhova and Justin F. Schneiderman and Dmitrii I. Altukhov and Tatiana A. Stroganova and Elena V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1186_s13229-022-00498-2.pdf},
doi = {10.1186/s13229-022-00498-2},
issn = {2040-2392},
year = {2022},
date = {2022-05-12},
urldate = {2022-05-12},
journal = {Molecular Autism},
volume = {13},
number = {1},
publisher = {Springer Science and Business Media LLC},
abstract = {Background
Altered neuronal excitation–inhibition (E–I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E–I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E–I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability.
Methods
Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below–average (< 85) IQ. MEG was recorded at rest with eyes open/closed in 49 boys with ASD aged 6–15 years with IQ ranging from 54 to 128, and in 49 age-matched typically developing (TD) boys. The cortical source activity was estimated using the beamformer approach and individual brain models. We then extracted the 1/f slope by fitting a linear function to the log–log-scale power spectra in the high-frequency range.
Results
The global 1/f slope averaged over all cortical sources demonstrated high rank-order stability between the two conditions. Consistent with previous research, it was steeper in the eyes-closed than in the eyes-open condition and flattened with age. Regardless of condition, children with ASD and below-average IQ had flatter slopes than either TD or ASD children with average or above-average IQ. These group differences could not be explained by differences in signal-to-noise ratio or periodic (alpha and beta) activity.
Limitations
Further research is needed to find out whether the observed changes in E–I ratios are characteristic of children with below-average IQ of other diagnostic groups.
Conclusions
The atypically flattened spectral slope of aperiodic activity in children with ASD and below-average IQ suggests a shift of the global E–I balance toward hyper-excitation. The spectral slope can provide an accessible noninvasive biomarker of the E–I ratio for making objective judgments about treatment effectiveness in people with ASD and comorbid intellectual disability.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background
Altered neuronal excitation–inhibition (E–I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E–I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E–I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability.
Methods
Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below–average (< 85) IQ. MEG was recorded at rest with eyes open/closed in 49 boys with ASD aged 6–15 years with IQ ranging from 54 to 128, and in 49 age-matched typically developing (TD) boys. The cortical source activity was estimated using the beamformer approach and individual brain models. We then extracted the 1/f slope by fitting a linear function to the log–log-scale power spectra in the high-frequency range.
Results
The global 1/f slope averaged over all cortical sources demonstrated high rank-order stability between the two conditions. Consistent with previous research, it was steeper in the eyes-closed than in the eyes-open condition and flattened with age. Regardless of condition, children with ASD and below-average IQ had flatter slopes than either TD or ASD children with average or above-average IQ. These group differences could not be explained by differences in signal-to-noise ratio or periodic (alpha and beta) activity.
Limitations
Further research is needed to find out whether the observed changes in E–I ratios are characteristic of children with below-average IQ of other diagnostic groups.
Conclusions
The atypically flattened spectral slope of aperiodic activity in children with ASD and below-average IQ suggests a shift of the global E–I balance toward hyper-excitation. The spectral slope can provide an accessible noninvasive biomarker of the E–I ratio for making objective judgments about treatment effectiveness in people with ASD and comorbid intellectual disability.
Altered neuronal excitation–inhibition (E–I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E–I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E–I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability.
Methods
Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below–average (< 85) IQ. MEG was recorded at rest with eyes open/closed in 49 boys with ASD aged 6–15 years with IQ ranging from 54 to 128, and in 49 age-matched typically developing (TD) boys. The cortical source activity was estimated using the beamformer approach and individual brain models. We then extracted the 1/f slope by fitting a linear function to the log–log-scale power spectra in the high-frequency range.
Results
The global 1/f slope averaged over all cortical sources demonstrated high rank-order stability between the two conditions. Consistent with previous research, it was steeper in the eyes-closed than in the eyes-open condition and flattened with age. Regardless of condition, children with ASD and below-average IQ had flatter slopes than either TD or ASD children with average or above-average IQ. These group differences could not be explained by differences in signal-to-noise ratio or periodic (alpha and beta) activity.
Limitations
Further research is needed to find out whether the observed changes in E–I ratios are characteristic of children with below-average IQ of other diagnostic groups.
Conclusions
The atypically flattened spectral slope of aperiodic activity in children with ASD and below-average IQ suggests a shift of the global E–I balance toward hyper-excitation. The spectral slope can provide an accessible noninvasive biomarker of the E–I ratio for making objective judgments about treatment effectiveness in people with ASD and comorbid intellectual disability.
32.
Kozunova, Galina L.; Sayfulina, Ksenia E.; Prokofyev, Andrey O.; Medvedev, Vladimir A.; Rytikova, Anna M.; Stroganova, Tatiana A.; Chernyshev, Boris V. (2022). Pupil dilation and response slowing distinguish deliberate explorative choices in the probabilistic learning task. Cognitive, Affective, & Behavioral Neuroscience, 22(5), 1108-1129. https://doi.org/10.3758/s13415-022-00996-z
@article{Kozunova2022b,
title = {Pupil dilation and response slowing distinguish deliberate explorative choices in the probabilistic learning task},
author = {Galina L. Kozunova and Ksenia E. Sayfulina and Andrey O. Prokofyev and Vladimir A. Medvedev and Anna M. Rytikova and Tatiana A. Stroganova and Boris V. Chernyshev},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3758_s13415-022-00996-z.pdf},
doi = {10.3758/s13415-022-00996-z},
issn = {1531-135X},
year = {2022},
date = {2022-04-01},
urldate = {2022-04-01},
journal = {Cognitive, Affective, & Behavioral Neuroscience },
volume = {22},
number = {5},
pages = {1108-1129},
publisher = {Springer Science and Business Media LLC},
abstract = {This study examined whether pupil size and response time would distinguish directed exploration from random exploration and exploitation. Eighty-nine participants performed the two-choice probabilistic learning task while their pupil size and response time were continuously recorded. Using LMM analysis, we estimated differences in the pupil size and response time between the advantageous and disadvantageous choices as a function of learning success, i.e., whether or not a participant has learned the probabilistic contingency between choices and their outcomes. We proposed that before a true value of each choice became known to a decision-maker, both advantageous and disadvantageous choices represented a random exploration of the two options with an equally uncertain outcome, whereas the same choices after learning manifested exploitation and direct exploration strategies, respectively. We found that disadvantageous choices were associated with increases both in response time and pupil size, but only after the participants had learned the choice-reward contingencies. For the pupil size, this effect was strongly amplified for those disadvantageous choices that immediately followed gains as compared to losses in the preceding choice. Pupil size modulations were evident during the behavioral choice rather than during the pretrial baseline. These findings suggest that occasional disadvantageous choices, which violate the acquired internal utility model, represent directed exploration. This exploratory strategy shifts choice priorities in favor of information seeking and its autonomic and behavioral concomitants are mainly driven by the conflict between the behavioral plan of the intended exploratory choice and its strong alternative, which has already proven to be more rewarding.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
This study examined whether pupil size and response time would distinguish directed exploration from random exploration and exploitation. Eighty-nine participants performed the two-choice probabilistic learning task while their pupil size and response time were continuously recorded. Using LMM analysis, we estimated differences in the pupil size and response time between the advantageous and disadvantageous choices as a function of learning success, i.e., whether or not a participant has learned the probabilistic contingency between choices and their outcomes. We proposed that before a true value of each choice became known to a decision-maker, both advantageous and disadvantageous choices represented a random exploration of the two options with an equally uncertain outcome, whereas the same choices after learning manifested exploitation and direct exploration strategies, respectively. We found that disadvantageous choices were associated with increases both in response time and pupil size, but only after the participants had learned the choice-reward contingencies. For the pupil size, this effect was strongly amplified for those disadvantageous choices that immediately followed gains as compared to losses in the preceding choice. Pupil size modulations were evident during the behavioral choice rather than during the pretrial baseline. These findings suggest that occasional disadvantageous choices, which violate the acquired internal utility model, represent directed exploration. This exploratory strategy shifts choice priorities in favor of information seeking and its autonomic and behavioral concomitants are mainly driven by the conflict between the behavioral plan of the intended exploratory choice and its strong alternative, which has already proven to be more rewarding.
2021
31.
Manyukhina, Viktoriya O.; Rostovtseva, Ekaterina N.; Prokofyev, Andrey O.; Obukhova, Tatiana S.; Schneiderman, Justin F.; Stroganova, Tatiana A.; Orekhova, Elena V. (2021). Visual gamma oscillations predict sensory sensitivity in females as they do in males. Scientific Reports, 11(1), 12013. https://doi.org/10.1038/s41598-021-91381-2
@article{Manyukhina2021,
title = {Visual gamma oscillations predict sensory sensitivity in females as they do in males},
author = {Viktoriya O. Manyukhina and Ekaterina N. Rostovtseva and Andrey O. Prokofyev and Tatiana S. Obukhova and Justin F. Schneiderman and Tatiana A. Stroganova and Elena V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1038_s41598-021-91381-2.pdf},
doi = {10.1038/s41598-021-91381-2},
issn = {2045-2322},
year = {2021},
date = {2021-12-00},
urldate = {2021-12-00},
journal = {Scientific Reports},
volume = {11},
number = {1},
pages = {12013},
publisher = {Springer Science and Business Media LLC},
abstract = {Gamma oscillations are driven by local cortical excitatory (E)–inhibitory (I) loops and may help to characterize neural processing involving excitatory-inhibitory interactions. In the visual cortex reliable gamma oscillations can be recorded with magnetoencephalography (MEG) in the majority of individuals, which makes visual gamma an attractive candidate for biomarkers of brain disorders associated with E/I imbalance. Little is known, however, about if/how these oscillations reflect individual differences in neural excitability and associated sensory/perceptual phenomena. The power of visual gamma response (GR) changes nonlinearly with increasing stimulation intensity: it increases with transition from static to slowly drifting high-contrast grating and then attenuates with further increase in the drift rate. In a recent MEG study we found that the GR attenuation predicted sensitivity to sensory stimuli in everyday life in neurotypical adult men and in men with autism spectrum disorders. Here, we replicated these results in neurotypical female participants. The GR enhancement with transition from static to slowly drifting grating did not correlate significantly with the sensory sensitivity measures. These findings suggest that weak velocity-related attenuation of the GR is a reliable neural concomitant of visual hypersensitivity and that the degree of GR attenuation may provide useful information about E/I balance in the visual cortex.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gamma oscillations are driven by local cortical excitatory (E)–inhibitory (I) loops and may help to characterize neural processing involving excitatory-inhibitory interactions. In the visual cortex reliable gamma oscillations can be recorded with magnetoencephalography (MEG) in the majority of individuals, which makes visual gamma an attractive candidate for biomarkers of brain disorders associated with E/I imbalance. Little is known, however, about if/how these oscillations reflect individual differences in neural excitability and associated sensory/perceptual phenomena. The power of visual gamma response (GR) changes nonlinearly with increasing stimulation intensity: it increases with transition from static to slowly drifting high-contrast grating and then attenuates with further increase in the drift rate. In a recent MEG study we found that the GR attenuation predicted sensitivity to sensory stimuli in everyday life in neurotypical adult men and in men with autism spectrum disorders. Here, we replicated these results in neurotypical female participants. The GR enhancement with transition from static to slowly drifting grating did not correlate significantly with the sensory sensitivity measures. These findings suggest that weak velocity-related attenuation of the GR is a reliable neural concomitant of visual hypersensitivity and that the degree of GR attenuation may provide useful information about E/I balance in the visual cortex.
30.
Smirnov, Kirill; Stroganova, Tatiana; Molholm, Sophie; Sysoeva, Olga (2021). Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies. International Journal of Molecular Sciences, 22(10), 5308. https://doi.org/10.3390/ijms22105308
@article{Smirnov2021,
title = {Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies},
author = {Kirill Smirnov and Tatiana Stroganova and Sophie Molholm and Olga Sysoeva},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3390_ijms22105308.pdf},
doi = {10.3390/ijms22105308},
issn = {1422-0067},
year = {2021},
date = {2021-05-18},
urldate = {2021-05-18},
journal = {International Journal of Molecular Sciences},
volume = {22},
number = {10},
pages = {5308},
publisher = {MDPI AG},
abstract = {Rett syndrome (RTT) is a rare neurodevelopmental disorder that is usually caused by mutations of the MECP2 gene. Patients with RTT suffer from severe deficits in motor, perceptual and cognitive domains. Electroencephalogram (EEG) has provided useful information to clinicians and scientists, from the very first descriptions of RTT, and yet no reliable neurophysiological biomarkers related to the pathophysiology of the disorder or symptom severity have been identified to date. To identify consistently observed and potentially informative EEG characteristics of RTT pathophysiology, and ascertain areas most worthy of further systematic investigation, here we review the literature for EEG abnormalities reported in patients with RTT and in its disease models. While pointing to some promising potential EEG biomarkers of RTT, our review identify areas of need to realize the potential of EEG including (1) quantitative investigation of promising clinical-EEG observations in RTT, e.g., shift of mu rhythm frequency and EEG during sleep; (2) closer alignment of approaches between patients with RTT and its animal models to strengthen the translational significance of the work (e.g., EEG measurements and behavioral states); (3) establishment of large-scale consortium research, to provide adequate Ns to investigate age and genotype effects.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Rett syndrome (RTT) is a rare neurodevelopmental disorder that is usually caused by mutations of the MECP2 gene. Patients with RTT suffer from severe deficits in motor, perceptual and cognitive domains. Electroencephalogram (EEG) has provided useful information to clinicians and scientists, from the very first descriptions of RTT, and yet no reliable neurophysiological biomarkers related to the pathophysiology of the disorder or symptom severity have been identified to date. To identify consistently observed and potentially informative EEG characteristics of RTT pathophysiology, and ascertain areas most worthy of further systematic investigation, here we review the literature for EEG abnormalities reported in patients with RTT and in its disease models. While pointing to some promising potential EEG biomarkers of RTT, our review identify areas of need to realize the potential of EEG including (1) quantitative investigation of promising clinical-EEG observations in RTT, e.g., shift of mu rhythm frequency and EEG during sleep; (2) closer alignment of approaches between patients with RTT and its animal models to strengthen the translational significance of the work (e.g., EEG measurements and behavioral states); (3) establishment of large-scale consortium research, to provide adequate Ns to investigate age and genotype effects.
2020
29.
Stroganova, T. A.; Komarov, K. S.; Sysoeva, O. V.; Goiaeva, D. E.; Obukhova, T. S.; Ovsiannikova, T. M.; Prokofyev, A. O.; Orekhova, E. V. (2020). Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD. Molecular Autism, 11, 100. https://doi.org/10.1186/s13229-020-00408-4
@article{Stroganova2020,
title = {Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD},
author = {T. A. Stroganova and K. S. Komarov and O. V. Sysoeva and D. E. Goiaeva and T. S. Obukhova and T. M. Ovsiannikova and A. O. Prokofyev and E. V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1186_s13229-020-00408-4.pdf},
doi = {10.1186/s13229-020-00408-4},
issn = {2040-2392},
year = {2020},
date = {2020-12-31},
urldate = {2020-12-31},
journal = {Molecular Autism},
volume = {11},
pages = {100},
publisher = {Springer Science and Business Media LLC},
abstract = {Background
Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses—the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD.
Methods
We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N = 35) and neurotypical (NT) boys (N = 35) aged 7–12-years.
Results
In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms.
Limitations
We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative.
Conclusion
Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background
Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses—the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD.
Methods
We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N = 35) and neurotypical (NT) boys (N = 35) aged 7–12-years.
Results
In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms.
Limitations
We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative.
Conclusion
Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody.
Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses—the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD.
Methods
We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N = 35) and neurotypical (NT) boys (N = 35) aged 7–12-years.
Results
In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms.
Limitations
We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative.
Conclusion
Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody.
28.
Строганова, Т. А.; Комаров, К. С.; Гояева, Д. Э.; Обухова, Т. С.; Овсянникова, Т. М.; Прокофьев, А. О.; Орехова, Е. В. (2020). Влияние периодичности и гласности звука на ответы слуховой коры мозга детей. Журнал высшей нервной деятельности им. И. П. Павлова, 71(4), 563-577. https://doi.org/10.31857/S0044467721040109
@article{nokey,
title = {Влияние периодичности и гласности звука на ответы слуховой коры мозга детей},
author = {Строганова, Т.А. and Комаров, К.С. and Гояева, Д.Э. and Обухова, Т.С. and Овсянникова, Т.М. and Прокофьев, А.О. and Орехова, Е.В.},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.31857_S0044467721040109.pdf},
doi = {10.31857/S0044467721040109},
year = {2020},
date = {2020-12-22},
urldate = {2020-12-22},
journal = {Журнал высшей нервной деятельности им. И. П. Павлова},
volume = {71},
number = {4},
pages = {563-577},
publisher = {Российская академия наук},
abstract = {Механизмы мозга человека, направленные на декодирование звуков речи, представляют как фундаментальный, так и практический интерес для многих областей нейронауки. Настоящая работа посвящена роли периодичности и речевой природы (фиксированной формантной структуры) гласных звуков в модуляции активности слуховой коры мозга у типично развивающихся детей. Мы предположили, что, хотя обе этих характеристики свойственны гласным звукам речи, их обработка осуществляется разными нейронными сетями слуховой коры. Для проверки этой гипотезы мы сконструировали набор акустических стимулов, манипулируя их периодичностью и гласностью по отдельности, и использовали магнитоэнцефалографию в сочетании с индивидуальными моделями поверхности коры мозга для оценки кортикальной топографии источников и силы ответов слуховой коры мозга. Выборку составили девять типично развивающихся детей в возрасте 7–12 лет. Мы обнаружили высокую чувствительность ранних ответов слуховой коры (50–150 мс после начала стимула) как к периодичности, так и к гласности звука, при независимой настройке нейронных сетей на каждое из этих свойств звуков речи. Различия в локализации, временной динамике и полушарной асимметрии этих дифференциальных ответов указывали на то, что “зоны гласности звука” в височной коре являются наиболее ранним уровнем в иерархии обработки речевой информации, на котором обработка собственно акустических свойств периодического звука трансформируется в декодирование звуков речи. Полученные результаты позволят оценить специфику и роль возможных нарушений обработки низкоуровневых свойств речевых звуков в трудностях восприятия речи у детей с первазивными расстройствами развития.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Механизмы мозга человека, направленные на декодирование звуков речи, представляют как фундаментальный, так и практический интерес для многих областей нейронауки. Настоящая работа посвящена роли периодичности и речевой природы (фиксированной формантной структуры) гласных звуков в модуляции активности слуховой коры мозга у типично развивающихся детей. Мы предположили, что, хотя обе этих характеристики свойственны гласным звукам речи, их обработка осуществляется разными нейронными сетями слуховой коры. Для проверки этой гипотезы мы сконструировали набор акустических стимулов, манипулируя их периодичностью и гласностью по отдельности, и использовали магнитоэнцефалографию в сочетании с индивидуальными моделями поверхности коры мозга для оценки кортикальной топографии источников и силы ответов слуховой коры мозга. Выборку составили девять типично развивающихся детей в возрасте 7–12 лет. Мы обнаружили высокую чувствительность ранних ответов слуховой коры (50–150 мс после начала стимула) как к периодичности, так и к гласности звука, при независимой настройке нейронных сетей на каждое из этих свойств звуков речи. Различия в локализации, временной динамике и полушарной асимметрии этих дифференциальных ответов указывали на то, что “зоны гласности звука” в височной коре являются наиболее ранним уровнем в иерархии обработки речевой информации, на котором обработка собственно акустических свойств периодического звука трансформируется в декодирование звуков речи. Полученные результаты позволят оценить специфику и роль возможных нарушений обработки низкоуровневых свойств речевых звуков в трудностях восприятия речи у детей с первазивными расстройствами развития.
27.
Kozunov, Vladimir V.; West, Timothy O.; Nikolaeva, Anastasia Y.; Stroganova, Tatiana A.; Friston, Karl J. (2020). Object recognition is enabled by an experience-dependent appraisal of visual features in the brain’s value system. NeuroImage, 221, 117143. https://doi.org/10.1016/j.neuroimage.2020.117143
@article{Kozunov2020,
title = {Object recognition is enabled by an experience-dependent appraisal of visual features in the brain’s value system},
author = {Vladimir V. Kozunov and Timothy O. West and Anastasia Y. Nikolaeva and Tatiana A. Stroganova and Karl J. Friston},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1016_j.neuroimage.2020.117143.pdf},
doi = {10.1016/j.neuroimage.2020.117143},
issn = {1053-8119},
year = {2020},
date = {2020-11-01},
urldate = {2020-11-01},
journal = {NeuroImage},
volume = {221},
pages = {117143},
publisher = {Elsevier BV},
abstract = {This paper addresses perceptual synthesis by comparing responses evoked by visual stimuli before and after they are recognized, depending on prior exposure. Using magnetoencephalography, we analyzed distributed patterns of neuronal activity – evoked by Mooney figures – before and after they were recognized as meaningful objects. Recognition induced changes were first seen at 100–120 ms, for both faces and tools. These early effects – in right inferior and middle occipital regions – were characterized by an increase in power in the absence of any changes in spatial patterns of activity. Within a later 210–230 ms window, a quite different type of recognition effect appeared. Regions of the brain’s value system (insula, entorhinal cortex and cingulate of the right hemisphere for faces and right orbitofrontal cortex for tools) evinced a reorganization of their neuronal activity without an overall power increase in the region. Finally, we found that during the perception of disambiguated face stimuli, a face-specific response in the right fusiform gyrus emerged at 240–290 ms, with a much greater latency than the well-known N170m component, and, crucially, followed the recognition effect in the value system regions. These results can clarify one of the most intriguing issues of perceptual synthesis, namely, how a limited set of high-level predictions, which is required to reduce the uncertainty when resolving the ill-posed inverse problem of perception, can be available before category-specific processing in visual cortex. We suggest that a subset of local spatial features serves as partial cues for a fast re-activation of object-specific appraisal by the value system. The ensuing top-down feedback from value system to visual cortex, in particular, the fusiform gyrus enables high levels of processing to form category-specific predictions. This descending influence of the value system was more prominent for faces than for tools, the fact that reflects different dependence of these categories on value-related information.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
This paper addresses perceptual synthesis by comparing responses evoked by visual stimuli before and after they are recognized, depending on prior exposure. Using magnetoencephalography, we analyzed distributed patterns of neuronal activity – evoked by Mooney figures – before and after they were recognized as meaningful objects. Recognition induced changes were first seen at 100–120 ms, for both faces and tools. These early effects – in right inferior and middle occipital regions – were characterized by an increase in power in the absence of any changes in spatial patterns of activity. Within a later 210–230 ms window, a quite different type of recognition effect appeared. Regions of the brain’s value system (insula, entorhinal cortex and cingulate of the right hemisphere for faces and right orbitofrontal cortex for tools) evinced a reorganization of their neuronal activity without an overall power increase in the region. Finally, we found that during the perception of disambiguated face stimuli, a face-specific response in the right fusiform gyrus emerged at 240–290 ms, with a much greater latency than the well-known N170m component, and, crucially, followed the recognition effect in the value system regions. These results can clarify one of the most intriguing issues of perceptual synthesis, namely, how a limited set of high-level predictions, which is required to reduce the uncertainty when resolving the ill-posed inverse problem of perception, can be available before category-specific processing in visual cortex. We suggest that a subset of local spatial features serves as partial cues for a fast re-activation of object-specific appraisal by the value system. The ensuing top-down feedback from value system to visual cortex, in particular, the fusiform gyrus enables high levels of processing to form category-specific predictions. This descending influence of the value system was more prominent for faces than for tools, the fact that reflects different dependence of these categories on value-related information.
26.
Razorenova, Alexandra M.; Chernyshev, Boris V.; Nikolaeva, Anastasia Yu; Butorina, Anna V.; Prokofyev, Andrey O.; Tyulenev, Nikita B.; Stroganova, Tatiana A. (2020). Rapid Cortical Plasticity Induced by Active Associative Learning of Novel Words in Human Adults. Frontiers in Neuroscience, 14, 895. https://doi.org/10.3389/fnins.2020.00895
@article{Razorenova2020b,
title = {Rapid Cortical Plasticity Induced by Active Associative Learning of Novel Words in Human Adults},
author = {Alexandra M. Razorenova and Boris V. Chernyshev and Anastasia Yu Nikolaeva and Anna V. Butorina and Andrey O. Prokofyev and Nikita B. Tyulenev and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnins.2020.00895.pdf},
doi = {10.3389/fnins.2020.00895},
issn = {1662-453X},
year = {2020},
date = {2020-09-11},
urldate = {2020-09-11},
journal = {Frontiers in Neuroscience},
volume = {14},
pages = {895},
publisher = {Frontiers Media SA},
abstract = {Human speech requires that new words are routinely memorized, yet neurocognitive mechanisms of such acquisition of memory remain highly debatable. Major controversy concerns the question whether cortical plasticity related to word learning occurs in neocortical speech-related areas immediately after learning, or neocortical plasticity emerges only on the second day after a prolonged time required for consolidation after learning. The functional spatiotemporal pattern of cortical activity related to such learning also remains largely unknown. In order to address these questions, we examined magnetoencephalographic responses elicited in the cerebral cortex by passive presentations of eight novel pseudowords before and immediately after an operant conditioning task. This associative procedure forced participants to perform an active search for unique meaning of four pseudowords that referred to movements of left and right hands and feet. The other four pseudowords did not require any movement and thus were not associated with any meaning. Familiarization with novel pseudowords led to a bilateral repetition suppression of cortical responses to them; the effect started before or around the uniqueness point and lasted for more than 500 ms. After learning, response amplitude to pseudowords that acquired meaning was greater compared with response amplitude to pseudowords that were not assigned meaning; the effect was significant within 144–362 ms after the uniqueness point, and it was found only in the left hemisphere. Within this time interval, a learning-related selective response initially emerged in cortical areas surrounding the Sylvian fissure: anterior superior temporal sulcus, ventral premotor cortex, the anterior part of intraparietal sulcus and insula. Later within this interval, activation additionally spread to more anterior higher-tier brain regions, and reached the left temporal pole and the triangular part of the left inferior frontal gyrus extending to its orbital part. Altogether, current findings evidence rapid plastic changes in cortical representations of meaningful auditory word-forms occurring almost immediately after learning. Additionally, our results suggest that familiarization resulting from stimulus repetition and semantic acquisition resulting from an active learning procedure have separable effects on cortical activity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Human speech requires that new words are routinely memorized, yet neurocognitive mechanisms of such acquisition of memory remain highly debatable. Major controversy concerns the question whether cortical plasticity related to word learning occurs in neocortical speech-related areas immediately after learning, or neocortical plasticity emerges only on the second day after a prolonged time required for consolidation after learning. The functional spatiotemporal pattern of cortical activity related to such learning also remains largely unknown. In order to address these questions, we examined magnetoencephalographic responses elicited in the cerebral cortex by passive presentations of eight novel pseudowords before and immediately after an operant conditioning task. This associative procedure forced participants to perform an active search for unique meaning of four pseudowords that referred to movements of left and right hands and feet. The other four pseudowords did not require any movement and thus were not associated with any meaning. Familiarization with novel pseudowords led to a bilateral repetition suppression of cortical responses to them; the effect started before or around the uniqueness point and lasted for more than 500 ms. After learning, response amplitude to pseudowords that acquired meaning was greater compared with response amplitude to pseudowords that were not assigned meaning; the effect was significant within 144–362 ms after the uniqueness point, and it was found only in the left hemisphere. Within this time interval, a learning-related selective response initially emerged in cortical areas surrounding the Sylvian fissure: anterior superior temporal sulcus, ventral premotor cortex, the anterior part of intraparietal sulcus and insula. Later within this interval, activation additionally spread to more anterior higher-tier brain regions, and reached the left temporal pole and the triangular part of the left inferior frontal gyrus extending to its orbital part. Altogether, current findings evidence rapid plastic changes in cortical representations of meaningful auditory word-forms occurring almost immediately after learning. Additionally, our results suggest that familiarization resulting from stimulus repetition and semantic acquisition resulting from an active learning procedure have separable effects on cortical activity.
25.
Orekhova, Elena V.; Rostovtseva, Ekaterina N.; Manyukhina, Viktoriya O.; Prokofiev, Andrey O.; Obukhova, Tatiana S.; Nikolaeva, Anastasia Yu.; Schneiderman, Justin F.; Stroganova, Tatiana A. (2020). Spatial suppression in visual motion perception is driven by inhibition: Evidence from MEG gamma oscillations. NeuroImage, 213, 116753. https://doi.org/10.1016/j.neuroimage.2020.116753
@article{Orekhova2020,
title = {Spatial suppression in visual motion perception is driven by inhibition: Evidence from MEG gamma oscillations},
author = {Elena V. Orekhova and Ekaterina N. Rostovtseva and Viktoriya O. Manyukhina and Andrey O. Prokofiev and Tatiana S. Obukhova and Anastasia Yu. Nikolaeva and Justin F. Schneiderman and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1016_j.neuroimage.2020.116753.pdf},
doi = {10.1016/j.neuroimage.2020.116753},
issn = {1053-8119},
year = {2020},
date = {2020-06-00},
urldate = {2020-06-00},
journal = {NeuroImage},
volume = {213},
pages = {116753},
publisher = {Elsevier BV},
abstract = {Spatial suppression (SS) is a visual perceptual phenomenon that is manifest in a reduction of directional sensitivity for drifting high-contrast gratings whose size exceeds the center of the visual field. Gratings moving at faster velocities induce stronger SS. The neural processes that give rise to such size- and velocity-dependent reductions in directional sensitivity are currently unknown, and the role of surround inhibition is unclear. In magnetoencephalogram (MEG), large high-contrast drifting gratings induce a strong gamma response (GR), which also attenuates with an increase in the gratings’ velocity. It has been suggested that the slope of this GR attenuation is mediated by inhibitory interactions in the primary visual cortex. Herein, we investigate whether SS is related to this inhibitory-based MEG measure. We evaluated SS and GR in two independent samples of participants: school-age boys and adult women. The slope of GR attenuation predicted inter-individual differences in SS in both samples. Test-retest reliability of the neuro-behavioral correlation was assessed in the adults, and was high between two sessions separated by several days or weeks. Neither frequencies nor absolute amplitudes of the GRs correlated with SS, which highlights the functional relevance of velocity-related changes in GR magnitude caused by augmentation of incoming input. Our findings provide evidence that links the psychophysical phenomenon of SS to inhibitory-based neural responses in the human primary visual cortex. This supports the role of inhibitory interactions as an important underlying mechanism for spatial suppression.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Spatial suppression (SS) is a visual perceptual phenomenon that is manifest in a reduction of directional sensitivity for drifting high-contrast gratings whose size exceeds the center of the visual field. Gratings moving at faster velocities induce stronger SS. The neural processes that give rise to such size- and velocity-dependent reductions in directional sensitivity are currently unknown, and the role of surround inhibition is unclear. In magnetoencephalogram (MEG), large high-contrast drifting gratings induce a strong gamma response (GR), which also attenuates with an increase in the gratings’ velocity. It has been suggested that the slope of this GR attenuation is mediated by inhibitory interactions in the primary visual cortex. Herein, we investigate whether SS is related to this inhibitory-based MEG measure. We evaluated SS and GR in two independent samples of participants: school-age boys and adult women. The slope of GR attenuation predicted inter-individual differences in SS in both samples. Test-retest reliability of the neuro-behavioral correlation was assessed in the adults, and was high between two sessions separated by several days or weeks. Neither frequencies nor absolute amplitudes of the GRs correlated with SS, which highlights the functional relevance of velocity-related changes in GR magnitude caused by augmentation of incoming input. Our findings provide evidence that links the psychophysical phenomenon of SS to inhibitory-based neural responses in the human primary visual cortex. This supports the role of inhibitory interactions as an important underlying mechanism for spatial suppression.
24.
Orekhova, Elena V.; Prokofyev, Andrey O.; Nikolaeva, Anastasia Yu.; Schneiderman, Justin F.; Stroganova, Tatiana A. (2020). Additive effect of contrast and velocity suggests the role of strong excitatory drive in suppression of visual gamma response. PLoS ONE, 15(2), e0228937. https://doi.org/10.1371/journal.pone.0228937
@article{Orekhova2020b,
title = {Additive effect of contrast and velocity suggests the role of strong excitatory drive in suppression of visual gamma response},
author = {Elena V. Orekhova and Andrey O. Prokofyev and Anastasia Yu. Nikolaeva and Justin F. Schneiderman and Tatiana A. Stroganova},
editor = {César Rennó‐Costa},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1371_journal.pone.0228937.pdf},
doi = {10.1371/journal.pone.0228937},
issn = {1932-6203},
year = {2020},
date = {2020-02-13},
urldate = {2020-02-13},
journal = {PLoS ONE},
volume = {15},
number = {2},
pages = {e0228937},
publisher = {Public Library of Science (PLoS)},
abstract = {It is commonly acknowledged that gamma-band oscillations arise from interplay between neural excitation and inhibition; however, the neural mechanisms controlling the power of stimulus-induced gamma responses (GR) in the human brain remain poorly understood. A moderate increase in velocity of drifting gratings results in GR power enhancement, while increasing the velocity beyond some ‘transition point’ leads to GR power attenuation. We tested two alternative explanations for this nonlinear input-output dependency in the GR power. First, the GR power can be maximal at the preferable velocity/temporal frequency of motion-sensitive V1 neurons. This ‘velocity tuning’ hypothesis predicts that lowering contrast either will not affect the transition point or shift it to a lower velocity. Second, the GR power attenuation at high velocities of visual motion can be caused by changes in excitation/inhibition balance with increasing excitatory drive. Since contrast and velocity both add to excitatory drive, this ‘excitatory drive’ hypothesis predicts that the ‘transition point’ for low-contrast gratings would be reached at a higher velocity, as compared to high-contrast gratings. To test these alternatives, we recorded magnetoencephalography during presentation of low (50%) and high (100%) contrast gratings drifting at four velocities. We found that lowering contrast led to a highly reliable shift of the GR suppression transition point to higher velocities, thus supporting the excitatory drive hypothesis. No effects of contrast or velocity were found in the alpha-beta range. The results have implications for understanding the mechanisms of gamma oscillations and developing gamma-based biomarkers of disturbed excitation/inhibition balance in brain disorders.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
It is commonly acknowledged that gamma-band oscillations arise from interplay between neural excitation and inhibition; however, the neural mechanisms controlling the power of stimulus-induced gamma responses (GR) in the human brain remain poorly understood. A moderate increase in velocity of drifting gratings results in GR power enhancement, while increasing the velocity beyond some ‘transition point’ leads to GR power attenuation. We tested two alternative explanations for this nonlinear input-output dependency in the GR power. First, the GR power can be maximal at the preferable velocity/temporal frequency of motion-sensitive V1 neurons. This ‘velocity tuning’ hypothesis predicts that lowering contrast either will not affect the transition point or shift it to a lower velocity. Second, the GR power attenuation at high velocities of visual motion can be caused by changes in excitation/inhibition balance with increasing excitatory drive. Since contrast and velocity both add to excitatory drive, this ‘excitatory drive’ hypothesis predicts that the ‘transition point’ for low-contrast gratings would be reached at a higher velocity, as compared to high-contrast gratings. To test these alternatives, we recorded magnetoencephalography during presentation of low (50%) and high (100%) contrast gratings drifting at four velocities. We found that lowering contrast led to a highly reliable shift of the GR suppression transition point to higher velocities, thus supporting the excitatory drive hypothesis. No effects of contrast or velocity were found in the alpha-beta range. The results have implications for understanding the mechanisms of gamma oscillations and developing gamma-based biomarkers of disturbed excitation/inhibition balance in brain disorders.
2019
23.
Sysoeva, Olga V.; Smirnov, Kirill; Stroganova, Tatiana A. (2019). Sensory evoked potentials in patients with Rett syndrome through the lens of animal studies: Systematic review. Clinical Neurophysiology, 131(1), 213-224. https://doi.org/10.1016/j.clinph.2019.11.003
@article{Sysoeva2020,
title = {Sensory evoked potentials in patients with Rett syndrome through the lens of animal studies: Systematic review},
author = {Olga V. Sysoeva and Kirill Smirnov and Tatiana A. Stroganova},
doi = {10.1016/j.clinph.2019.11.003},
issn = {1388-2457},
year = {2019},
date = {2019-11-21},
urldate = {2020-01-00},
journal = {Clinical Neurophysiology},
volume = {131},
number = {1},
pages = {213-224},
publisher = {Elsevier BV},
abstract = {Objective: Systematically review the abnormalities in event related potential (ERP) recorded in Rett Syndrome (RTT) patients and animals in search of translational biomarkers of deficits related to the particular neurophysiological processes of known genetic origin (MECP2 mutations).
Methods: Pubmed, ISI Web of Knowledge and BIORXIV were searched for the relevant articles according to PRISMA standards.
Results: ERP components are generally delayed across all sensory modalities both in RTT patients and its animal model, while findings on ERPs amplitude strongly depend on stimulus properties and presentation rate. Studies on RTT animal models uncovered the abnormalities in the excitatory and inhibitory transmission as critical mechanisms underlying the ERPs changes, but showed that even similar ERP alterations in auditory and visual domains have a diverse neural basis. A range of novel approaches has been developed in animal studies bringing along the meaningful neurophysiological interpretation of ERP measures in RTT patients.
Conclusions: While there is a clear evidence for sensory ERPs abnormalities in RTT, to further advance the field there is a need in a large-scale ERP studies with the functionally-relevant experimental paradigms.
Significance: The review provides insights into domain-specific neural basis of the ERP abnormalities and promotes clinical application of the ERP measures as the non-invasive functional biomarkers of RTT pathophysiology.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Objective: Systematically review the abnormalities in event related potential (ERP) recorded in Rett Syndrome (RTT) patients and animals in search of translational biomarkers of deficits related to the particular neurophysiological processes of known genetic origin (MECP2 mutations).
Methods: Pubmed, ISI Web of Knowledge and BIORXIV were searched for the relevant articles according to PRISMA standards.
Results: ERP components are generally delayed across all sensory modalities both in RTT patients and its animal model, while findings on ERPs amplitude strongly depend on stimulus properties and presentation rate. Studies on RTT animal models uncovered the abnormalities in the excitatory and inhibitory transmission as critical mechanisms underlying the ERPs changes, but showed that even similar ERP alterations in auditory and visual domains have a diverse neural basis. A range of novel approaches has been developed in animal studies bringing along the meaningful neurophysiological interpretation of ERP measures in RTT patients.
Conclusions: While there is a clear evidence for sensory ERPs abnormalities in RTT, to further advance the field there is a need in a large-scale ERP studies with the functionally-relevant experimental paradigms.
Significance: The review provides insights into domain-specific neural basis of the ERP abnormalities and promotes clinical application of the ERP measures as the non-invasive functional biomarkers of RTT pathophysiology.
Methods: Pubmed, ISI Web of Knowledge and BIORXIV were searched for the relevant articles according to PRISMA standards.
Results: ERP components are generally delayed across all sensory modalities both in RTT patients and its animal model, while findings on ERPs amplitude strongly depend on stimulus properties and presentation rate. Studies on RTT animal models uncovered the abnormalities in the excitatory and inhibitory transmission as critical mechanisms underlying the ERPs changes, but showed that even similar ERP alterations in auditory and visual domains have a diverse neural basis. A range of novel approaches has been developed in animal studies bringing along the meaningful neurophysiological interpretation of ERP measures in RTT patients.
Conclusions: While there is a clear evidence for sensory ERPs abnormalities in RTT, to further advance the field there is a need in a large-scale ERP studies with the functionally-relevant experimental paradigms.
Significance: The review provides insights into domain-specific neural basis of the ERP abnormalities and promotes clinical application of the ERP measures as the non-invasive functional biomarkers of RTT pathophysiology.
22.
Ulanov, M. A.; Shtyrov, Y. Y.; Stroganova, T. A. (2019). Transcranial Direct Current Stimulation as a Tool to Induce Language Recovery in Patients with Post-Stroke Aphasia. Neuroscience and Behavioral Physiology, 49(9), 1169-1180. https://doi.org/10.1007/s11055-019-00854-5
@article{Ulanov2019,
title = {Transcranial Direct Current Stimulation as a Tool to Induce Language Recovery in Patients with Post-Stroke Aphasia},
author = {M. A. Ulanov and Y. Y. Shtyrov and T. A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1007_s11055-019-00854-5.pdf},
doi = {10.1007/s11055-019-00854-5},
issn = {1573-899X},
year = {2019},
date = {2019-11-00},
urldate = {2019-11-00},
journal = {Neuroscience and Behavioral Physiology},
volume = {49},
number = {9},
pages = {1169-1180},
publisher = {The Russian Academy of Sciences},
abstract = {In recent years, possible therapeutic effects of transcranial direct current stimulation (tDCS) have been widely investigated in studies dealing with different types of neural pathologies. Initially, tDCS was applied for treatment of patients with motor stroke; later on, it was introduced into studies of patients with Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, schizophrenia and post-stroke aphasia. Recent reviews of tDCS application in patients with post-stroke aphasia did not provide coherent evidence on the tDCS efficiency. There were no uniform protocols of stimulation used, patients’ selection criteria were highly divergent, and the reports of treatment outcomes varied dramatically. In this review, we will focus on the reported heterogeneity of tDCS effects trying to disentangle its putative underpinnings rooted in the diversity of lesion types, aphasia severity and recovery stages. Given the current theoretical models suggesting the qualitatively different patterns of brain activity to accompany post-stroke aphasia recovery, a number of physiological factors should be taken into account to choose optimal tDCS parameters. With this in mind, we assess results of ten studies applying tDCS in post-stroke aphasia treatment, and, based on this analysis, suggest directions for further research in this rapidly developing field.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
In recent years, possible therapeutic effects of transcranial direct current stimulation (tDCS) have been widely investigated in studies dealing with different types of neural pathologies. Initially, tDCS was applied for treatment of patients with motor stroke; later on, it was introduced into studies of patients with Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, schizophrenia and post-stroke aphasia. Recent reviews of tDCS application in patients with post-stroke aphasia did not provide coherent evidence on the tDCS efficiency. There were no uniform protocols of stimulation used, patients’ selection criteria were highly divergent, and the reports of treatment outcomes varied dramatically. In this review, we will focus on the reported heterogeneity of tDCS effects trying to disentangle its putative underpinnings rooted in the diversity of lesion types, aphasia severity and recovery stages. Given the current theoretical models suggesting the qualitatively different patterns of brain activity to accompany post-stroke aphasia recovery, a number of physiological factors should be taken into account to choose optimal tDCS parameters. With this in mind, we assess results of ten studies applying tDCS in post-stroke aphasia treatment, and, based on this analysis, suggest directions for further research in this rapidly developing field.
21.
Pavlova, Anna A.; Butorina, Anna V.; Nikolaeva, Anastasia Y.; Prokofyev, Andrey O.; Ulanov, Maxim A.; Bondarev, Denis P.; Stroganova, Tatiana A. (2019). Effortful verb retrieval from semantic memory drives beta suppression in mesial frontal regions involved in action initiation. Human Brain Mapping, 40(12), 3669-3681. https://doi.org/10.1002/hbm.24624
@article{Pavlova2019b,
title = {Effortful verb retrieval from semantic memory drives beta suppression in mesial frontal regions involved in action initiation},
author = {Anna A. Pavlova and Anna V. Butorina and Anastasia Y. Nikolaeva and Andrey O. Prokofyev and Maxim A. Ulanov and Denis P. Bondarev and Tatiana A. Stroganova},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.24624},
doi = {10.1002/hbm.24624},
issn = {1097-0193},
year = {2019},
date = {2019-08-15},
urldate = {2019-08-15},
journal = {Human Brain Mapping},
volume = {40},
number = {12},
pages = {3669-3681},
publisher = {Wiley},
abstract = {The contribution of the motor cortex to the semantic retrieval of verbs remains a subject of debate in neuroscience. Here, we examined whether additional engagement of the cortical motor system was required when access to verbs semantics was hindered during a verb generation task. We asked participants to produce verbs related to presented noun cues that were either strongly associated with a single verb to prompt fast and effortless verb retrieval, or were weakly associated with multiple verbs and more difficult to respond to. Using power suppression of magnetoencephalography beta oscillations (15–30 Hz) as an index of cortical activation, we performed a whole‐brain analysis in order to identify the cortical regions sensitive to the difficulty of verb semantic retrieval. Highly reliable suppression of beta oscillations occurred 250 ms after the noun cue presentation and was sustained until the onset of verbal response. This was localized to multiple cortical regions, mainly in the temporal and frontal lobes of the left hemisphere. Crucially, the only cortical regions where beta suppression was sensitive to the task difficulty, were the higher order motor areas on the medial and lateral surfaces of the frontal lobe. Stronger activation of the premotor cortex and supplementary motor area accompanied the effortful verb retrieval and preceded the preparation of verbal responses for more than 500 ms, thus, overlapping with the time window of verb retrieval from semantic memory. Our results suggest that reactivation of verb‐related motor plans in higher order motor circuitry promotes the semantic retrieval of target verbs.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The contribution of the motor cortex to the semantic retrieval of verbs remains a subject of debate in neuroscience. Here, we examined whether additional engagement of the cortical motor system was required when access to verbs semantics was hindered during a verb generation task. We asked participants to produce verbs related to presented noun cues that were either strongly associated with a single verb to prompt fast and effortless verb retrieval, or were weakly associated with multiple verbs and more difficult to respond to. Using power suppression of magnetoencephalography beta oscillations (15–30 Hz) as an index of cortical activation, we performed a whole‐brain analysis in order to identify the cortical regions sensitive to the difficulty of verb semantic retrieval. Highly reliable suppression of beta oscillations occurred 250 ms after the noun cue presentation and was sustained until the onset of verbal response. This was localized to multiple cortical regions, mainly in the temporal and frontal lobes of the left hemisphere. Crucially, the only cortical regions where beta suppression was sensitive to the task difficulty, were the higher order motor areas on the medial and lateral surfaces of the frontal lobe. Stronger activation of the premotor cortex and supplementary motor area accompanied the effortful verb retrieval and preceded the preparation of verbal responses for more than 500 ms, thus, overlapping with the time window of verb retrieval from semantic memory. Our results suggest that reactivation of verb‐related motor plans in higher order motor circuitry promotes the semantic retrieval of target verbs.
20.
Korosteleva, Anastasia; Ushakov, Vadim; Orlov, Vyacheslav; Stroganova, Tatiana; Velichkovskiy, Boris (2019). Neurophysiological Correlators of Semantic Features. Biologically Inspired Cognitive Architectures 2019. BICA 2019. Advances in Intelligent Systems and Computing, vol 948.. Springer, Cham. 240--245. https://doi.org/10.1007/978-3-030-25719-4_31
@conference{Korosteleva2019,
title = {Neurophysiological Correlators of Semantic Features},
author = {Anastasia Korosteleva and Vadim Ushakov and Vyacheslav Orlov and Tatiana Stroganova and Boris Velichkovskiy},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1007_978-3-030-25719-4_31.pdf},
doi = {10.1007/978-3-030-25719-4_31},
isbn = {9783030257194},
year = {2019},
date = {2019-07-17},
urldate = {2019-07-17},
booktitle = {Biologically Inspired Cognitive Architectures 2019. BICA 2019. Advances in Intelligent Systems and Computing, vol 948.},
pages = {240--245},
publisher = {Springer, Cham},
abstract = {The article presents the result of fMRI data processing - a map and characteristics of brain activity in the process of monitoring human speech activity. Experimental data calculated by 8 subjects. The main goal of the work was to localize the spatial and temporal dynamics of the neural networks of the cortex, which is responsible for the mechanism of verbal control. The secondary goal of the work was to recognize and remove noise components from the fMRI signal, which are related to human physiology and a feature of the test items.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
The article presents the result of fMRI data processing - a map and characteristics of brain activity in the process of monitoring human speech activity. Experimental data calculated by 8 subjects. The main goal of the work was to localize the spatial and temporal dynamics of the neural networks of the cortex, which is responsible for the mechanism of verbal control. The secondary goal of the work was to recognize and remove noise components from the fMRI signal, which are related to human physiology and a feature of the test items.
19.
Orekhova, Elena V.; Stroganova, Tatiana A.; Schneiderman, Justin F.; Lundström, Sebastian; Riaz, Bushra; Sarovic, Darko; Sysoeva, Olga V.; Brant, Georg; Gillberg, Christopher; Hadjikhani, Nouchine (2019). Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity. Human Brain Mapping, 40(5), 1583-1593. https://doi.org/10.1002/hbm.24469
@article{Orekhova2018b,
title = {Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity},
author = {Elena V. Orekhova and Tatiana A. Stroganova and Justin F. Schneiderman and Sebastian Lundström and Bushra Riaz and Darko Sarovic and Olga V. Sysoeva and Georg Brant and Christopher Gillberg and Nouchine Hadjikhani},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.24469},
doi = {10.1002/hbm.24469},
issn = {1097-0193},
year = {2019},
date = {2019-04-01},
urldate = {2019-04-01},
journal = {Human Brain Mapping},
volume = {40},
number = {5},
pages = {1583-1593},
publisher = {Wiley},
abstract = {Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. To test this prediction, we assessed the link between self-reported sensitivity and changes in magneto-encephalographic gamma oscillations as a function of motion velocity of high-contrast visual gratings. The induced gamma oscillations increased in frequency and decreased in power with increasing stimulation intensity. As expected, weaker suppression of the gamma response correlated with sensory hypersensitivity. Robustness of this result was confirmed by its replication in the two samples: neurotypical subjects and people with autism, who had generally elevated sensory sensitivity. We conclude that intensity-related suppression of gamma response is a promising biomarker of homeostatic control of the excitation-inhibition balance in the visual cortex.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. To test this prediction, we assessed the link between self-reported sensitivity and changes in magneto-encephalographic gamma oscillations as a function of motion velocity of high-contrast visual gratings. The induced gamma oscillations increased in frequency and decreased in power with increasing stimulation intensity. As expected, weaker suppression of the gamma response correlated with sensory hypersensitivity. Robustness of this result was confirmed by its replication in the two samples: neurotypical subjects and people with autism, who had generally elevated sensory sensitivity. We conclude that intensity-related suppression of gamma response is a promising biomarker of homeostatic control of the excitation-inhibition balance in the visual cortex.
2018
18.
Уланов, М. А.; Штыров, Ю. Ю.; Строганова, Т. А. (2018). Транскраниальная микрополяризация как метод стимуляции восстановления речи у пациентов с постинсультной афазией. Журнал высшей нервной деятельности им. И.П. Павлова, 68(6), 703-718. https://doi.org/10.1134/s0044467718060114
@article{Ulanov2018,
title = {Транскраниальная микрополяризация как метод стимуляции восстановления речи у пациентов с постинсультной афазией},
author = {Уланов, М.А. and Штыров, Ю.Ю. and Строганова, Т.А.},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1134_s0044467718060114.pdf},
doi = {10.1134/s0044467718060114},
issn = {0044-4677},
year = {2018},
date = {2018-12-00},
urldate = {2018-12-00},
journal = {Журнал высшей нервной деятельности им. И.П. Павлова},
volume = {68},
number = {6},
pages = {703-718},
publisher = {Российская академия наук},
abstract = {В последние годы возможные терапевтические эффекты транскраниальной микрополяризации подробно изучались в работах, посвященных различным неврологическим патологиям. Изначально транскраниальная микрополяризация использовалась для восстановления двигательных функций у пациентов, перенесших инсульт. Позже она стала применяться в исследованиях пациентов с болезнью Альцгеймера, Паркинсона, пациентов с
шизофренией, а также с постинсультной афазией. Последние обзоры результатов использования транскраниальной микрополяризации для восстановления речи у пациентов с
постинсультной афазией не приводят надежных доказательств ее эффективности. В работах по данной проблематике отсутствуют стандартные протоколы микрополяризации, пациенты объединяются в выборки по очень разнородным критериям, данные об исходах терапии чрезвычайно расходятся. В этом обзоре мы сосредоточились на индивидуальных
различиях эффектов микрополяризации у пациентов с постинсультной афазией и попытались раскрыть причины этих различий. Предположительно, они обусловлены разнообразием локализации поражений, степени речевых нарушений и стадий восстановления у пациентов с афазией. Современные теоретические модели описывают различные паттерны
мозговой активности, связанные с восстановлением речи при афазии. Следовательно, для
оптимального использования микрополяризации необходимо принимать во внимание
множество физиологических факторов. Исходя из этого, мы проанализировали результаты десяти исследований, использующих транскраниальную микрополяризацию для восстановления речи при постинсультной афазии. Также, основываясь на результатах нашего
анализа, мы обозначили направления для дальнейших исследований в этой стремительно
развивающейся области.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
В последние годы возможные терапевтические эффекты транскраниальной микрополяризации подробно изучались в работах, посвященных различным неврологическим патологиям. Изначально транскраниальная микрополяризация использовалась для восстановления двигательных функций у пациентов, перенесших инсульт. Позже она стала применяться в исследованиях пациентов с болезнью Альцгеймера, Паркинсона, пациентов с
шизофренией, а также с постинсультной афазией. Последние обзоры результатов использования транскраниальной микрополяризации для восстановления речи у пациентов с
постинсультной афазией не приводят надежных доказательств ее эффективности. В работах по данной проблематике отсутствуют стандартные протоколы микрополяризации, пациенты объединяются в выборки по очень разнородным критериям, данные об исходах терапии чрезвычайно расходятся. В этом обзоре мы сосредоточились на индивидуальных
различиях эффектов микрополяризации у пациентов с постинсультной афазией и попытались раскрыть причины этих различий. Предположительно, они обусловлены разнообразием локализации поражений, степени речевых нарушений и стадий восстановления у пациентов с афазией. Современные теоретические модели описывают различные паттерны
мозговой активности, связанные с восстановлением речи при афазии. Следовательно, для
оптимального использования микрополяризации необходимо принимать во внимание
множество физиологических факторов. Исходя из этого, мы проанализировали результаты десяти исследований, использующих транскраниальную микрополяризацию для восстановления речи при постинсультной афазии. Также, основываясь на результатах нашего
анализа, мы обозначили направления для дальнейших исследований в этой стремительно
развивающейся области.
шизофренией, а также с постинсультной афазией. Последние обзоры результатов использования транскраниальной микрополяризации для восстановления речи у пациентов с
постинсультной афазией не приводят надежных доказательств ее эффективности. В работах по данной проблематике отсутствуют стандартные протоколы микрополяризации, пациенты объединяются в выборки по очень разнородным критериям, данные об исходах терапии чрезвычайно расходятся. В этом обзоре мы сосредоточились на индивидуальных
различиях эффектов микрополяризации у пациентов с постинсультной афазией и попытались раскрыть причины этих различий. Предположительно, они обусловлены разнообразием локализации поражений, степени речевых нарушений и стадий восстановления у пациентов с афазией. Современные теоретические модели описывают различные паттерны
мозговой активности, связанные с восстановлением речи при афазии. Следовательно, для
оптимального использования микрополяризации необходимо принимать во внимание
множество физиологических факторов. Исходя из этого, мы проанализировали результаты десяти исследований, использующих транскраниальную микрополяризацию для восстановления речи при постинсультной афазии. Также, основываясь на результатах нашего
анализа, мы обозначили направления для дальнейших исследований в этой стремительно
развивающейся области.
17.
Orekhova, Elena V.; Sysoeva, Olga V.; Schneiderman, Justin F.; Lundström, Sebastian; Galuta, Ilia A.; Goiaeva, Dzerasa E.; Prokofyev, Andrey O.; Riaz, Bushra; Keeler, Courtney; Hadjikhani, Nouchine; Gillberg, Christopher; Stroganova, Tatiana A. (2018). Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex. Scientific reports, 8(1), 8451. https://doi.org/10.1038/s41598-018-26779-6
@article{Orekhova2018c,
title = {Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex},
author = {Elena V. Orekhova and Olga V. Sysoeva and Justin F. Schneiderman and Sebastian Lundström and Ilia A. Galuta and Dzerasa E. Goiaeva and Andrey O. Prokofyev and Bushra Riaz and Courtney Keeler and Nouchine Hadjikhani and Christopher Gillberg and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1038_s41598-018-26779-6.pdf},
doi = {10.1038/s41598-018-26779-6},
issn = {2045-2322},
year = {2018},
date = {2018-05-31},
urldate = {2018-05-31},
journal = {Scientific reports},
volume = {8},
number = {1},
pages = {8451},
publisher = {Springer Science and Business Media LLC},
abstract = {Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sought to find a similar input-output relationship in humans with MEG via modulating the intensity of a visual stimulation by changing the velocity/temporal-frequency of visual motion. In the first experiment, adult participants observed static and moving gratings. The frequency of the MEG gamma response monotonically increased with motion velocity whereas power followed a bell-shape. In the second experiment, on a large group of children and adults, we found that despite drastic developmental changes in frequency and power of gamma oscillations, the relative suppression at high motion velocities was scaled to the same range of values across the life-span. In light of animal and modeling studies, the modulation of gamma power and frequency at high stimulation intensities characterizes the capacity of inhibitory neurons to counterbalance increasing excitation in visual networks. Gamma suppression may thus provide a non-invasive measure of inhibitory-based gain control in the healthy and diseased brain.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sought to find a similar input-output relationship in humans with MEG via modulating the intensity of a visual stimulation by changing the velocity/temporal-frequency of visual motion. In the first experiment, adult participants observed static and moving gratings. The frequency of the MEG gamma response monotonically increased with motion velocity whereas power followed a bell-shape. In the second experiment, on a large group of children and adults, we found that despite drastic developmental changes in frequency and power of gamma oscillations, the relative suppression at high motion velocities was scaled to the same range of values across the life-span. In light of animal and modeling studies, the modulation of gamma power and frequency at high stimulation intensities characterizes the capacity of inhibitory neurons to counterbalance increasing excitation in visual networks. Gamma suppression may thus provide a non-invasive measure of inhibitory-based gain control in the healthy and diseased brain.
16.
Koptelova, A.; Bikmullina, R.; Medvedovsky, M.; Novikova, S.; Golovteev, A.; Grinenko, O.; Korsakova, M.; Kozlova, A.; Arkhipova, N.; Vorobyev, A.; Melikyan, A.; Paetau, R.; Stroganova, T.; Metsähonkala, L. (2018). Ictal and interictal MEG in pediatric patients with tuberous sclerosis and drug resistant epilepsy. Epilepsy Research, 140, 162-165. https://doi.org/10.1016/j.eplepsyres.2017.12.014
@article{Koptelova2018,
title = {Ictal and interictal MEG in pediatric patients with tuberous sclerosis and drug resistant epilepsy},
author = {A. Koptelova and R. Bikmullina and M. Medvedovsky and S. Novikova and A. Golovteev and O. Grinenko and M. Korsakova and A. Kozlova and N. Arkhipova and A. Vorobyev and A. Melikyan and R. Paetau and T. Stroganova and L. Metsähonkala},
doi = {10.1016/j.eplepsyres.2017.12.014},
issn = {0920-1211},
year = {2018},
date = {2018-02-00},
urldate = {2018-02-00},
journal = {Epilepsy Research},
volume = {140},
pages = {162-165},
publisher = {Elsevier BV},
abstract = {Purpose: Drug resistant epilepsy (DRE) is common in patients with tuberous sclerosis (TS). Interictal MEG has been shown as a valuable instrument in the presurgical workup. The goal of our study was to evaluate the role of ictal MEG in epileptogenic tuber selection, especially in patients with multiple irritative zones.
Methods: The clinical and MEG data of 23 patients with TS and DRE from two medical/research centers were reviewed. Seven pediatric patients, who had seizures during MEG recording and underwent resection or disconnection surgery, were included into the study. Cortical sources of ictal and interictal epileptiform MEG discharges were compared with epileptogenic zone location in six patients with favorable surgery outcome.
Results: In patients who improved substantially after surgery all resected and several other tubers demonstrated epileptiform activity on interictal MEG. Ictal MEG provided crucial information about lobar location of the seizure onset zone (SOZ) in two cases, and in the other four it confirmed the SOZ location derived from the interictal data. In one case, ictal MEG findings were unreliable. In one patient, who did not benefit from surgical treatment, the resected tubers did not overlap with interictal and ictal MEG sources.
Conclusion: The combination of interictal and ictal MEG is a valuable tool for identification of the epileptogenic tuber/tubers in presurgical work-up in patients with TS.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Purpose: Drug resistant epilepsy (DRE) is common in patients with tuberous sclerosis (TS). Interictal MEG has been shown as a valuable instrument in the presurgical workup. The goal of our study was to evaluate the role of ictal MEG in epileptogenic tuber selection, especially in patients with multiple irritative zones.
Methods: The clinical and MEG data of 23 patients with TS and DRE from two medical/research centers were reviewed. Seven pediatric patients, who had seizures during MEG recording and underwent resection or disconnection surgery, were included into the study. Cortical sources of ictal and interictal epileptiform MEG discharges were compared with epileptogenic zone location in six patients with favorable surgery outcome.
Results: In patients who improved substantially after surgery all resected and several other tubers demonstrated epileptiform activity on interictal MEG. Ictal MEG provided crucial information about lobar location of the seizure onset zone (SOZ) in two cases, and in the other four it confirmed the SOZ location derived from the interictal data. In one case, ictal MEG findings were unreliable. In one patient, who did not benefit from surgical treatment, the resected tubers did not overlap with interictal and ictal MEG sources.
Conclusion: The combination of interictal and ictal MEG is a valuable tool for identification of the epileptogenic tuber/tubers in presurgical work-up in patients with TS.
Methods: The clinical and MEG data of 23 patients with TS and DRE from two medical/research centers were reviewed. Seven pediatric patients, who had seizures during MEG recording and underwent resection or disconnection surgery, were included into the study. Cortical sources of ictal and interictal epileptiform MEG discharges were compared with epileptogenic zone location in six patients with favorable surgery outcome.
Results: In patients who improved substantially after surgery all resected and several other tubers demonstrated epileptiform activity on interictal MEG. Ictal MEG provided crucial information about lobar location of the seizure onset zone (SOZ) in two cases, and in the other four it confirmed the SOZ location derived from the interictal data. In one case, ictal MEG findings were unreliable. In one patient, who did not benefit from surgical treatment, the resected tubers did not overlap with interictal and ictal MEG sources.
Conclusion: The combination of interictal and ictal MEG is a valuable tool for identification of the epileptogenic tuber/tubers in presurgical work-up in patients with TS.
15.
Kozunov, Vladimir; Nikolaeva, Anastasia; Stroganova, Tatiana A. (2018). Categorization for Faces and Tools—Two Classes of Objects Shaped by Different Experience—Differs in Processing Timing, Brain Areas Involved, and Repetition Effects. Frontiers in Human Neuroscience, 11, 650. https://doi.org/10.3389/fnhum.2017.00650
@article{Kozunov2018,
title = {Categorization for Faces and Tools—Two Classes of Objects Shaped by Different Experience—Differs in Processing Timing, Brain Areas Involved, and Repetition Effects},
author = {Vladimir Kozunov and Anastasia Nikolaeva and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnhum.2017.00650.pdf},
doi = {10.3389/fnhum.2017.00650},
issn = {1662-5161},
year = {2018},
date = {2018-01-09},
urldate = {2018-01-09},
journal = {Frontiers in Human Neuroscience},
volume = {11},
pages = {650},
publisher = {Frontiers Media SA},
abstract = {The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se, or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140–170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210–220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions. Furthermore, we hypothesized and tested whether activity within face and tool-specific binding-related patterns would demonstrate oppositely acting effects following procedural perceptual learning. We found that activity in the ventral, face-specific network increased following the stimuli repetition. In contrast, tool processing in the dorsal network adapted by reducing its activity over the repetition period. Altogether, we have demonstrated that activity associated with visual processing of faces and tools during the categorization stage differ in processing timing, brain areas involved, and in their dynamics underlying stimuli learning.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se, or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140–170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210–220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions. Furthermore, we hypothesized and tested whether activity within face and tool-specific binding-related patterns would demonstrate oppositely acting effects following procedural perceptual learning. We found that activity in the ventral, face-specific network increased following the stimuli repetition. In contrast, tool processing in the dorsal network adapted by reducing its activity over the repetition period. Altogether, we have demonstrated that activity associated with visual processing of faces and tools during the categorization stage differ in processing timing, brain areas involved, and in their dynamics underlying stimuli learning.
14.
Козунова, Г. Л.; Воронин, Н. А.; Венидиктов, В. В.; Строганова, Т. А. (2018). Обучение с подкреплением: роль непосредственной обратной связи и внутренней модели ситуации. Журнал высшей нервной деятельности им. И.П. Павлова, 68(5), 602-613. https://doi.org/10.1134/s0044467718050076
@article{Козунова2018,
title = {Обучение с подкреплением: роль непосредственной обратной связи и внутренней модели ситуации},
author = {Г. Л. Козунова and Н. А. Воронин and В. В. Венидиктов and Т. А. Строганова},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1134_s0044467718050076.pdf},
doi = {10.1134/s0044467718050076},
issn = {0044-4677},
year = {2018},
date = {2018-01-00},
urldate = {2018-01-00},
journal = {Журнал высшей нервной деятельности им. И.П. Павлова},
volume = {68},
number = {5},
pages = {602-613},
publisher = {Российская академия наук},
abstract = {Поведение человека в условиях частичной неопределенности исхода характеризуется соответствием частоты выполняемых действий вероятности их подкрепления. Мы исследовали роль вероятностных сигналов награды и наказания в этом феномене. 29 взрослых испытуемых выполняли задачу на выбор из двух альтернатив, где один стимул из пары вознаграждался в 70% случаев, а другой – в 30% случаев. Перед появлением предпочтения выгодного стимула у испытуемых возникала парадоксальная восприимчивость к редким, нерепрезентативным сигналам награды и наказания. Это указывает на наличие имплицитной оценки вероятности награды при выборе каждого стимула. Расхождение актуального результата с моделью провоцировало у испытуемых смену стратегии. Этот механизм может лежать в основе феномена вероятностного соответствия.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Поведение человека в условиях частичной неопределенности исхода характеризуется соответствием частоты выполняемых действий вероятности их подкрепления. Мы исследовали роль вероятностных сигналов награды и наказания в этом феномене. 29 взрослых испытуемых выполняли задачу на выбор из двух альтернатив, где один стимул из пары вознаграждался в 70% случаев, а другой – в 30% случаев. Перед появлением предпочтения выгодного стимула у испытуемых возникала парадоксальная восприимчивость к редким, нерепрезентативным сигналам награды и наказания. Это указывает на наличие имплицитной оценки вероятности награды при выборе каждого стимула. Расхождение актуального результата с моделью провоцировало у испытуемых смену стратегии. Этот механизм может лежать в основе феномена вероятностного соответствия.
13.
Николаева, А. Ю.; Строганова, Т. А. (2018). Влияние лексико-семантической обработки глаголов движения рук и ног на указательные движения тех же конечностей. Журнал высшей нервной деятельности им. И.П.Павлова, 68(5), 627-636. https://doi.org/10.1134/s0044467718050118
@article{Николаева2018,
title = {Влияние лексико-семантической обработки глаголов движения рук и ног на указательные движения тех же конечностей},
author = {А. Ю. Николаева and Т. А. Строганова},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1134_s0044467718050118.pdf},
doi = {10.1134/s0044467718050118},
issn = {0044-4677},
year = {2018},
date = {2018-00-00},
urldate = {2018-00-00},
journal = {Журнал высшей нервной деятельности им. И.П.Павлова},
volume = {68},
number = {5},
pages = {627-636},
publisher = {Российская академия наук},
abstract = {Согласно теории ассоциативного обучения, при восприятии глаголов “ходить” или “писать” происходит реактивация моторных нейронных репрезентаций руки или ноги, вовлеченных в осуществление соответствующих действий. Общая активация моторных зон
должна приводить к эффектам интерференции, т.е. к замедлению движения определенной
конечности при семантической обработке глагола, обозначающего ее движения. Целью
работы был анализ избирательности эффектов интерференции семантической обработки
глаголов, обозначающих движения рук и ног, с движениями этих же конечностей. Перед
испытуемыми (14 женщин, 14 мужчин, средний возраст 28 лет) стояла семантическая задача – определить конкретность/абстрактность глаголов, включавших в том числе глаголы
движения рук и ног. Испытуемые отвечали либо рукой, либо ногой, как правой, так и левой в зависимости от серии эксперимента. Результаты исследования показали, что обработка семантической информации о глаголах движения интерферирует с одновременными произвольными движениями конечностей, но не по соматотопическому принципу.
Выявленная избирательная интерференция говорит о том, что структуры левого полушария, вовлеченные в восприятие глаголов, частично задействуют те же мозговые механизмы, что и инициация движений правых конечностей, в особенности движений правой руки. Наши результаты не опровергают теорию ассоциативного обучения речи, но показывают, что ее предсказания нельзя проверить с помощью предназначенных для этой цели
поведенческих экспериментов.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Согласно теории ассоциативного обучения, при восприятии глаголов “ходить” или “писать” происходит реактивация моторных нейронных репрезентаций руки или ноги, вовлеченных в осуществление соответствующих действий. Общая активация моторных зон
должна приводить к эффектам интерференции, т.е. к замедлению движения определенной
конечности при семантической обработке глагола, обозначающего ее движения. Целью
работы был анализ избирательности эффектов интерференции семантической обработки
глаголов, обозначающих движения рук и ног, с движениями этих же конечностей. Перед
испытуемыми (14 женщин, 14 мужчин, средний возраст 28 лет) стояла семантическая задача – определить конкретность/абстрактность глаголов, включавших в том числе глаголы
движения рук и ног. Испытуемые отвечали либо рукой, либо ногой, как правой, так и левой в зависимости от серии эксперимента. Результаты исследования показали, что обработка семантической информации о глаголах движения интерферирует с одновременными произвольными движениями конечностей, но не по соматотопическому принципу.
Выявленная избирательная интерференция говорит о том, что структуры левого полушария, вовлеченные в восприятие глаголов, частично задействуют те же мозговые механизмы, что и инициация движений правых конечностей, в особенности движений правой руки. Наши результаты не опровергают теорию ассоциативного обучения речи, но показывают, что ее предсказания нельзя проверить с помощью предназначенных для этой цели
поведенческих экспериментов.
должна приводить к эффектам интерференции, т.е. к замедлению движения определенной
конечности при семантической обработке глагола, обозначающего ее движения. Целью
работы был анализ избирательности эффектов интерференции семантической обработки
глаголов, обозначающих движения рук и ног, с движениями этих же конечностей. Перед
испытуемыми (14 женщин, 14 мужчин, средний возраст 28 лет) стояла семантическая задача – определить конкретность/абстрактность глаголов, включавших в том числе глаголы
движения рук и ног. Испытуемые отвечали либо рукой, либо ногой, как правой, так и левой в зависимости от серии эксперимента. Результаты исследования показали, что обработка семантической информации о глаголах движения интерферирует с одновременными произвольными движениями конечностей, но не по соматотопическому принципу.
Выявленная избирательная интерференция говорит о том, что структуры левого полушария, вовлеченные в восприятие глаголов, частично задействуют те же мозговые механизмы, что и инициация движений правых конечностей, в особенности движений правой руки. Наши результаты не опровергают теорию ассоциативного обучения речи, но показывают, что ее предсказания нельзя проверить с помощью предназначенных для этой цели
поведенческих экспериментов.
2017
12.
Pavlova, Anna A.; Butorina, Anna V.; Nikolaeva, Anastasia Y.; Prokofyev, Andrey O.; Ulanov, Maxim A.; Stroganova, Tatiana A. (2017). Not all reading is alike: task modulation of magnetic evoked response to visual word. Psychology in Russia: State of the art, 10(3), 190-205. https://doi.org/10.11621/pir.2017.0313
@article{nokey,
title = {Not all reading is alike: task modulation of magnetic evoked response to visual word},
author = {Pavlova, Anna A. and Butorina, Anna V. and Nikolaeva, Anastasia Y. and Prokofyev, Andrey O. and Ulanov, Maxim A. and Stroganova, Tatiana A.},
doi = {10.11621/pir.2017.0313},
year = {2017},
date = {2017-12-00},
journal = {Psychology in Russia: State of the art},
volume = {10},
number = {3},
pages = {190-205},
publisher = {Russian Psychology Society},
abstract = {Background.
Previous studies have shown that brain response to a written word depends on the task: whether the word is a target in a version of lexical decision task or should be read silently. Although this effect has been interpreted as an evidence for an interaction between word recognition processes and task demands, it also may be caused by greater attention allocation to the target word.
Objective.
We aimed to examine the task effect on brain response evoked by non-target written words.
Design.
Using MEG and magnetic source imaging, we compared spatial-temporal pattern of brain response elicited by a noun cue when it was read silently either without additional task (SR) or with a requirement to produce an associated verb (VG).
Results.
The task demands penetrated into early (200-300 ms) and late (500-800 ms) stages of a word processing by enhancing brain response under VG versus SR condition. The cortical sources of the early response were localized to bilateral inferior occipitotem-poral and anterior temporal cortex suggesting that more demanding VG task required elaborated lexical-semantic analysis. The late effect was observed in the associative auditory areas in middle and superior temporal gyri and in motor representation of articulators. Our results suggest that a remote goal plays a pivotal role in enhanced recruitment of cortical structures underlying orthographic, semantic and sensorimotor dimensions of written word perception from the early processing stages. Surprisingly, we found that to full a more challenging goal the brain progressively engaged resources of the right hemisphere throughout all stages of silent reading. Conclusion. Our study demonstrates that a deeper processing of linguistic input amplies activation of brain areas involved in integration of speech perception and pro-duction. This is consistent with theories that emphasize the role of sensorimotor integration in speech understanding.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background.
Previous studies have shown that brain response to a written word depends on the task: whether the word is a target in a version of lexical decision task or should be read silently. Although this effect has been interpreted as an evidence for an interaction between word recognition processes and task demands, it also may be caused by greater attention allocation to the target word.
Objective.
We aimed to examine the task effect on brain response evoked by non-target written words.
Design.
Using MEG and magnetic source imaging, we compared spatial-temporal pattern of brain response elicited by a noun cue when it was read silently either without additional task (SR) or with a requirement to produce an associated verb (VG).
Results.
The task demands penetrated into early (200-300 ms) and late (500-800 ms) stages of a word processing by enhancing brain response under VG versus SR condition. The cortical sources of the early response were localized to bilateral inferior occipitotem-poral and anterior temporal cortex suggesting that more demanding VG task required elaborated lexical-semantic analysis. The late effect was observed in the associative auditory areas in middle and superior temporal gyri and in motor representation of articulators. Our results suggest that a remote goal plays a pivotal role in enhanced recruitment of cortical structures underlying orthographic, semantic and sensorimotor dimensions of written word perception from the early processing stages. Surprisingly, we found that to full a more challenging goal the brain progressively engaged resources of the right hemisphere throughout all stages of silent reading. Conclusion. Our study demonstrates that a deeper processing of linguistic input amplies activation of brain areas involved in integration of speech perception and pro-duction. This is consistent with theories that emphasize the role of sensorimotor integration in speech understanding.
Previous studies have shown that brain response to a written word depends on the task: whether the word is a target in a version of lexical decision task or should be read silently. Although this effect has been interpreted as an evidence for an interaction between word recognition processes and task demands, it also may be caused by greater attention allocation to the target word.
Objective.
We aimed to examine the task effect on brain response evoked by non-target written words.
Design.
Using MEG and magnetic source imaging, we compared spatial-temporal pattern of brain response elicited by a noun cue when it was read silently either without additional task (SR) or with a requirement to produce an associated verb (VG).
Results.
The task demands penetrated into early (200-300 ms) and late (500-800 ms) stages of a word processing by enhancing brain response under VG versus SR condition. The cortical sources of the early response were localized to bilateral inferior occipitotem-poral and anterior temporal cortex suggesting that more demanding VG task required elaborated lexical-semantic analysis. The late effect was observed in the associative auditory areas in middle and superior temporal gyri and in motor representation of articulators. Our results suggest that a remote goal plays a pivotal role in enhanced recruitment of cortical structures underlying orthographic, semantic and sensorimotor dimensions of written word perception from the early processing stages. Surprisingly, we found that to full a more challenging goal the brain progressively engaged resources of the right hemisphere throughout all stages of silent reading. Conclusion. Our study demonstrates that a deeper processing of linguistic input amplies activation of brain areas involved in integration of speech perception and pro-duction. This is consistent with theories that emphasize the role of sensorimotor integration in speech understanding.
11.
Butorina, Anna V.; Pavlova, Anna A.; Nikolaeva, Anastasia Y.; Prokofyev, Andrey O.; Bondarev, Denis P.; Stroganova, Tatiana A. (2017). Simultaneous Processing of Noun Cue and to-be-Produced Verb in Verb Generation Task: Electromagnetic Evidence. Frontiers in Human Neuroscience, 11, 279. https://doi.org/10.3389/fnhum.2017.00279
@article{Butorina2017,
title = {Simultaneous Processing of Noun Cue and to-be-Produced Verb in Verb Generation Task: Electromagnetic Evidence},
author = {Anna V. Butorina and Anna A. Pavlova and Anastasia Y. Nikolaeva and Andrey O. Prokofyev and Denis P. Bondarev and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnhum.2017.00279.pdf},
doi = {10.3389/fnhum.2017.00279},
issn = {1662-5161},
year = {2017},
date = {2017-05-30},
urldate = {2017-05-30},
journal = {Frontiers in Human Neuroscience},
volume = {11},
pages = {279},
publisher = {Frontiers Media SA},
abstract = {A long-standing but implicit assumption is that words strongly associated with a presented cue are automatically activated in the memory through rapid spread of activation within brain semantic networks. The current study was aimed to provide direct evidence of such rapid access to words’ semantic representations and to investigate its neural sources using magnetoencephalography (MEG) and distributed source localization technique. Thirty-three neurotypical subjects underwent the MEG recording during verb generation task, which was to produce verbs related to the presented noun cues. Brain responses evoked by the noun cues were examined while manipulating the strength of association between the noun and the potential verb responses. The strong vs. weak noun-verb association led to a greater noun-related neural response at 250–400 ms after cue onset, and faster verb production. The cortical sources of the differential response were localized in left temporal pole, previously implicated in semantic access, and left ventrolateral prefrontal cortex (VLPFC), thought to subserve controlled semantic retrieval. The strength of the left VLPFC’s response to the nouns with strong verb associates was positively correlated to the speed of verbs production. Our findings empirically validate the theoretical expectation that in case of a strongly connected noun-verb pair, successful access to target verb representation may occur already at the stage of lexico-semantic analysis of the presented noun. Moreover, the MEG results suggest that contrary to the previous conclusion derived from fMRI studies left VLPFC supports selection of the target verb representations, even if they were retrieved from semantic memory rapidly and effortlessly. The discordance between MEG and fMRI findings in verb generation task may stem from different modes of neural activation captured by phase-locked activity in MEG and slow changes of blood-oxygen-level-dependent (BOLD) signal in fMRI.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A long-standing but implicit assumption is that words strongly associated with a presented cue are automatically activated in the memory through rapid spread of activation within brain semantic networks. The current study was aimed to provide direct evidence of such rapid access to words’ semantic representations and to investigate its neural sources using magnetoencephalography (MEG) and distributed source localization technique. Thirty-three neurotypical subjects underwent the MEG recording during verb generation task, which was to produce verbs related to the presented noun cues. Brain responses evoked by the noun cues were examined while manipulating the strength of association between the noun and the potential verb responses. The strong vs. weak noun-verb association led to a greater noun-related neural response at 250–400 ms after cue onset, and faster verb production. The cortical sources of the differential response were localized in left temporal pole, previously implicated in semantic access, and left ventrolateral prefrontal cortex (VLPFC), thought to subserve controlled semantic retrieval. The strength of the left VLPFC’s response to the nouns with strong verb associates was positively correlated to the speed of verbs production. Our findings empirically validate the theoretical expectation that in case of a strongly connected noun-verb pair, successful access to target verb representation may occur already at the stage of lexico-semantic analysis of the presented noun. Moreover, the MEG results suggest that contrary to the previous conclusion derived from fMRI studies left VLPFC supports selection of the target verb representations, even if they were retrieved from semantic memory rapidly and effortlessly. The discordance between MEG and fMRI findings in verb generation task may stem from different modes of neural activation captured by phase-locked activity in MEG and slow changes of blood-oxygen-level-dependent (BOLD) signal in fMRI.
10.
Sysoeva, Olga V.; Galuta, Ilia A.; Davletshina, Maria S.; Orekhova, Elena V.; Stroganova, Tatiana A. (2017). Abnormal Size-Dependent Modulation of Motion Perception in Children with Autism Spectrum Disorder (ASD). Frontiers in Neuroscience, 11, 164. https://doi.org/10.3389/fnins.2017.00164
@article{Sysoeva2017,
title = {Abnormal Size-Dependent Modulation of Motion Perception in Children with Autism Spectrum Disorder (ASD)},
author = {Olga V. Sysoeva and Ilia A. Galuta and Maria S. Davletshina and Elena V. Orekhova and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnins.2017.00164.pdf},
doi = {10.3389/fnins.2017.00164},
issn = {1662-453X},
year = {2017},
date = {2017-03-29},
urldate = {2017-03-29},
journal = {Frontiers in Neuroscience},
volume = {11},
pages = {164},
publisher = {Frontiers Media SA},
abstract = {Excitation/Inhibition (E/I) imbalance in neural networks is now considered among the core neural underpinnings of autism psychopathology. In motion perception at least two phenomena critically depend on E/I balance in visual cortex: spatial suppression (SS), and spatial facilitation (SF) corresponding to impoverished or improved motion perception with increasing stimuli size, respectively. While SS is dominant at high contrast, SF is evident for low contrast stimuli, due to the prevalence of inhibitory contextual modulations in the former, and excitatory ones in the latter case. Only one previous study (Foss-Feig et al., 2013) investigated SS and SF in Autism Spectrum Disorder (ASD). Our study aimed to replicate previous findings, and to explore the putative contribution of deficient inhibitory influences into an enhanced SF index in ASD—a cornerstone for interpretation proposed by Foss-Feig et al. (2013). The SS and SF were examined in 40 boys with ASD, broad spectrum of intellectual abilities (63 < IQ < 127) and 44 typically developing (TD) boys, aged 6–15 years. The stimuli of small (1°) and large (12°) radius were presented under high (100%) and low (1%) contrast conditions. Social Responsiveness Scale and Sensory Profile Questionnaire were used to assess the autism severity and sensory processing abnormalities. We found that the SS index was atypically reduced, while SF index abnormally enhanced in children with ASD. The presence of abnormally enhanced SF in children with ASD was the only consistent finding between our study and that of Foss-Feig et al. While the SS and SF indexes were strongly interrelated in TD participants, this correlation was absent in their peers with ASD. In addition, the SF index but not the SS index correlated with the severity of autism and the poor registration abilities. The pattern of results is partially consistent with the idea of hypofunctional inhibitory transmission in visual areas in ASD. Nonetheless, the absence of correlation between SF and SS indexes paired with a strong direct link between abnormally enhanced SF and autism symptoms in our ASD sample emphasizes the role of the enhanced excitatory influences by themselves in the observed abnormalities in low-level visual phenomena found in ASD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Excitation/Inhibition (E/I) imbalance in neural networks is now considered among the core neural underpinnings of autism psychopathology. In motion perception at least two phenomena critically depend on E/I balance in visual cortex: spatial suppression (SS), and spatial facilitation (SF) corresponding to impoverished or improved motion perception with increasing stimuli size, respectively. While SS is dominant at high contrast, SF is evident for low contrast stimuli, due to the prevalence of inhibitory contextual modulations in the former, and excitatory ones in the latter case. Only one previous study (Foss-Feig et al., 2013) investigated SS and SF in Autism Spectrum Disorder (ASD). Our study aimed to replicate previous findings, and to explore the putative contribution of deficient inhibitory influences into an enhanced SF index in ASD—a cornerstone for interpretation proposed by Foss-Feig et al. (2013). The SS and SF were examined in 40 boys with ASD, broad spectrum of intellectual abilities (63 < IQ < 127) and 44 typically developing (TD) boys, aged 6–15 years. The stimuli of small (1°) and large (12°) radius were presented under high (100%) and low (1%) contrast conditions. Social Responsiveness Scale and Sensory Profile Questionnaire were used to assess the autism severity and sensory processing abnormalities. We found that the SS index was atypically reduced, while SF index abnormally enhanced in children with ASD. The presence of abnormally enhanced SF in children with ASD was the only consistent finding between our study and that of Foss-Feig et al. While the SS and SF indexes were strongly interrelated in TD participants, this correlation was absent in their peers with ASD. In addition, the SF index but not the SS index correlated with the severity of autism and the poor registration abilities. The pattern of results is partially consistent with the idea of hypofunctional inhibitory transmission in visual areas in ASD. Nonetheless, the absence of correlation between SF and SS indexes paired with a strong direct link between abnormally enhanced SF and autism symptoms in our ASD sample emphasizes the role of the enhanced excitatory influences by themselves in the observed abnormalities in low-level visual phenomena found in ASD.
2016
9.
Chernyshev, Boris V.; Pronko, Platon K.; Stroganova, Tatiana A. (2016). Early suppression effect in human primary visual cortex during Kanizsa illusion processing: A magnetoencephalographic evidence. Visual Neuroscience, 33, E007. https://doi.org/10.1017/s0952523816000031
@article{CHERNYSHEV2016,
title = {Early suppression effect in human primary visual cortex during Kanizsa illusion processing: A magnetoencephalographic evidence},
author = {Boris V. Chernyshev and Platon K. Pronko and Tatiana A. Stroganova},
doi = {10.1017/s0952523816000031},
issn = {1469-8714},
year = {2016},
date = {2016-03-16},
urldate = {2016-00-00},
journal = {Visual Neuroscience},
volume = {33},
pages = {E007},
publisher = {Maximum Academic Press},
abstract = {Detection of illusory contours (ICs) such as Kanizsa figures is known to depend primarily upon the lateral occipital complex. Yet there is no universal agreement on the role of the primary visual cortex in this process; some existing evidence hints that an early stage of the visual response in V1 may involve relative suppression to Kanizsa figures compared with controls. Iso-oriented luminance borders, which are responsible for Kanizsa illusion, may evoke surround suppression in V1 and adjacent areas leading to the reduction in the initial response to Kanizsa figures. We attempted to test the existence, as well as to find localization and timing of the early suppression effect produced by Kanizsa figures in adult nonclinical human participants. We used two sizes of visual stimuli (4.5 and 9.0°) in order to probe the effect at two different levels of eccentricity; the stimuli were presented centrally in passive viewing conditions. We recorded magnetoencephalogram, which is more sensitive than electroencephalogram to activity originating from V1 and V2 areas. We restricted our analysis to the medial occipital area and the occipital pole, and to a 40–120 ms time window after the stimulus onset. By applying threshold-free cluster enhancement technique in combination with permutation statistics, we were able to detect the inverted IC effect—a relative suppression of the response to the Kanizsa figures compared with the control stimuli. The current finding is highly compatible with the explanation involving surround suppression evoked by iso-oriented collinear borders. The effect may be related to the principle of sparse coding, according to which V1 suppresses representations of inner parts of collinear assemblies as being informationally redundant. Such a mechanism is likely to be an important preliminary step preceding object contour detection.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Detection of illusory contours (ICs) such as Kanizsa figures is known to depend primarily upon the lateral occipital complex. Yet there is no universal agreement on the role of the primary visual cortex in this process; some existing evidence hints that an early stage of the visual response in V1 may involve relative suppression to Kanizsa figures compared with controls. Iso-oriented luminance borders, which are responsible for Kanizsa illusion, may evoke surround suppression in V1 and adjacent areas leading to the reduction in the initial response to Kanizsa figures. We attempted to test the existence, as well as to find localization and timing of the early suppression effect produced by Kanizsa figures in adult nonclinical human participants. We used two sizes of visual stimuli (4.5 and 9.0°) in order to probe the effect at two different levels of eccentricity; the stimuli were presented centrally in passive viewing conditions. We recorded magnetoencephalogram, which is more sensitive than electroencephalogram to activity originating from V1 and V2 areas. We restricted our analysis to the medial occipital area and the occipital pole, and to a 40–120 ms time window after the stimulus onset. By applying threshold-free cluster enhancement technique in combination with permutation statistics, we were able to detect the inverted IC effect—a relative suppression of the response to the Kanizsa figures compared with the control stimuli. The current finding is highly compatible with the explanation involving surround suppression evoked by iso-oriented collinear borders. The effect may be related to the principle of sparse coding, according to which V1 suppresses representations of inner parts of collinear assemblies as being informationally redundant. Such a mechanism is likely to be an important preliminary step preceding object contour detection.
8.
Sysoeva, Olga V.; Davletshina, Maria A.; Orekhova, Elena V.; Galuta, Ilia A.; Stroganova, Tatiana A. (2016). Reduced Oblique Effect in Children with Autism Spectrum Disorders (ASD). Frontiers in Neuroscience, 9, 512. https://doi.org/10.3389/fnins.2015.00512
@article{Sysoeva2016,
title = {Reduced Oblique Effect in Children with Autism Spectrum Disorders (ASD)},
author = {Olga V. Sysoeva and Maria A. Davletshina and Elena V. Orekhova and Ilia A. Galuta and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnins.2015.00512.pdf},
doi = {10.3389/fnins.2015.00512},
issn = {1662-453X},
year = {2016},
date = {2016-01-21},
urldate = {2016-01-21},
journal = {Frontiers in Neuroscience},
volume = {9},
pages = {512},
publisher = {Frontiers Media SA},
abstract = {People are very precise in the discrimination of a line orientation relative to the cardinal (vertical and horizontal) axes, while their orientation discrimination sensitivity along the oblique axes is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the “oblique effect.” Given that the oblique effect is a basic feature of visual processing with an early developmental origin, its investigation in children with Autism Spectrum Disorder (ASD) may shed light on the nature of visual sensory abnormalities frequently reported in this population. We examined line orientation sensitivity along oblique and vertical axes in a sample of 26 boys with ASD (IQ > 68) and 38 typically developing (TD) boys aged 7–15 years, as well as in a subsample of carefully IQ-matched ASD and TD participants. Children were asked to detect the direction of tilt of a high-contrast black-and-white grating relative to vertical (90°) or oblique (45°) templates. The oblique effect was reduced in children with ASD as compared to TD participants, irrespective of their IQ. This reduction was due to poor orientation sensitivity along the vertical axis in ASD children, while their ability to discriminate line orientation along the oblique axis was unaffected. We speculate that this deficit in sensitivity to vertical orientation may reflect disrupted mechanisms of early experience-dependent learning that takes place during the critical period for orientation selectivity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
People are very precise in the discrimination of a line orientation relative to the cardinal (vertical and horizontal) axes, while their orientation discrimination sensitivity along the oblique axes is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the “oblique effect.” Given that the oblique effect is a basic feature of visual processing with an early developmental origin, its investigation in children with Autism Spectrum Disorder (ASD) may shed light on the nature of visual sensory abnormalities frequently reported in this population. We examined line orientation sensitivity along oblique and vertical axes in a sample of 26 boys with ASD (IQ > 68) and 38 typically developing (TD) boys aged 7–15 years, as well as in a subsample of carefully IQ-matched ASD and TD participants. Children were asked to detect the direction of tilt of a high-contrast black-and-white grating relative to vertical (90°) or oblique (45°) templates. The oblique effect was reduced in children with ASD as compared to TD participants, irrespective of their IQ. This reduction was due to poor orientation sensitivity along the vertical axis in ASD children, while their ability to discriminate line orientation along the oblique axis was unaffected. We speculate that this deficit in sensitivity to vertical orientation may reflect disrupted mechanisms of early experience-dependent learning that takes place during the critical period for orientation selectivity.
7.
Величковский, Б. М.; Нуждин, Ю. О.; Свирин, Е. П.; Строганова, Т. А.; Федорова, А. А.; Шишкин, С. Л. (2016). Управление «силой мысли»: На пути к новым формам взаимодействия человека с техническими устройствами. Вопросы психологии, 62(1), 78-88.
@bachelorthesis{nokey,
title = {Управление «силой мысли»: На пути к новым формам взаимодействия человека с техническими устройствами},
author = {Величковский, Б.М. and Нуждин, Ю.О. and Свирин, Е.П. and Строганова, Т.А. and Федорова, А.А. and Шишкин, С.Л.},
year = {2016},
date = {2016-01-00},
journal = {Вопросы психологии},
volume = {62},
number = {1},
pages = {78-88},
abstract = {Рассмотрены две группы перспективных интерфейсов, создаваемых сегодня для улучшения взаимодействия человека с техническими системами. Интерфейсы первой группы опираются на использование данных, получаемых с помощью методов нейрофизиологии и психофизиологии, прежде всего путем регистрации ЭЭГ/магнитоэнцефалограммы. Интерфейсы второй группы используют данные о микроповедении глаза человека, опираясь на методы айтрекинга, популярные в психологии и эргономике. Продемонстрирована полезность совмещения этих подходов для создания высокоскоростных гибридных интерфейсов, пригодных не только для обеспечения коммуникации лиц с тяжелыми нарушениями речи и моторики, но и для повышения эффективности работы здоровых пользователей операторских профессий. Критическую роль в таком развитии имеет решение ряда фундаментальных проблем психологической науки, таких как поддержка зон совместного внимания в процессах опосредствованного техникой общения и выявление намерений пользователя по характеристикам движений глаз и мозговой активности.},
keywords = {},
pubstate = {published},
tppubtype = {bachelorthesis}
}
Рассмотрены две группы перспективных интерфейсов, создаваемых сегодня для улучшения взаимодействия человека с техническими системами. Интерфейсы первой группы опираются на использование данных, получаемых с помощью методов нейрофизиологии и психофизиологии, прежде всего путем регистрации ЭЭГ/магнитоэнцефалограммы. Интерфейсы второй группы используют данные о микроповедении глаза человека, опираясь на методы айтрекинга, популярные в психологии и эргономике. Продемонстрирована полезность совмещения этих подходов для создания высокоскоростных гибридных интерфейсов, пригодных не только для обеспечения коммуникации лиц с тяжелыми нарушениями речи и моторики, но и для повышения эффективности работы здоровых пользователей операторских профессий. Критическую роль в таком развитии имеет решение ряда фундаментальных проблем психологической науки, таких как поддержка зон совместного внимания в процессах опосредствованного техникой общения и выявление намерений пользователя по характеристикам движений глаз и мозговой активности.
2015
6.
Stroganova, Tatiana A.; Butorina, Anna V.; Sysoeva, Olga V.; Prokofyev, Andrey O.; Nikolaeva, Anastasia Yu.; Tsetlin, Marina M.; Orekhova, Elena V. (2015). Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders. Journal of Neurodevelopmental Disorders, 7(1), 21. https://doi.org/10.1186/s11689-015-9121-x
@article{Stroganova2015,
title = {Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders},
author = {Tatiana A. Stroganova and Anna V. Butorina and Olga V. Sysoeva and Andrey O. Prokofyev and Anastasia Yu. Nikolaeva and Marina M. Tsetlin and Elena V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1186_s11689-015-9121-x.pdf},
doi = {10.1186/s11689-015-9121-x},
issn = {1866-1955},
year = {2015},
date = {2015-12-00},
urldate = {2015-12-00},
journal = {Journal of Neurodevelopmental Disorders},
volume = {7},
number = {1},
pages = {21},
publisher = {Springer Science and Business Media LLC},
abstract = {Background
Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50–120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of excitation of the fast-spiking inhibitory basket cells recruited by increasing strength of excitatory input. Therefore, the experimental manipulations affecting gamma frequency may throw light on inhibitory networks dysfunction in ASD.
Methods
Here, we used magnetoencephalography (MEG) to investigate modulation of visual gamma oscillation frequency by speed of drifting annular gratings (1.2, 3.6, 6.0 °/s) in 21 boys with ASD and 26 typically developing boys aged 7–15 years. Multitaper method was used for analysis of spectra of gamma power change upon stimulus presentation and permutation test was applied for statistical comparisons. We also assessed in our participants visual orientation discrimination thresholds, which are thought to depend on excitability of inhibitory networks in the visual cortex.
Results
Although frequency of the oscillatory gamma response increased with increasing velocity of visual motion in both groups of participants, the velocity effect was reduced in a substantial proportion of children with ASD. The range of velocity-related gamma frequency modulation correlated inversely with the ability to discriminate oblique line orientation in the ASD group, while no such correlation has been observed in the group of typically developing participants.
Conclusions
Our findings suggest that abnormal velocity-related gamma frequency modulation in ASD may constitute a potential biomarker for reduced excitability of fast-spiking inhibitory neurons in a subset of children with ASD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background
Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50–120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of excitation of the fast-spiking inhibitory basket cells recruited by increasing strength of excitatory input. Therefore, the experimental manipulations affecting gamma frequency may throw light on inhibitory networks dysfunction in ASD.
Methods
Here, we used magnetoencephalography (MEG) to investigate modulation of visual gamma oscillation frequency by speed of drifting annular gratings (1.2, 3.6, 6.0 °/s) in 21 boys with ASD and 26 typically developing boys aged 7–15 years. Multitaper method was used for analysis of spectra of gamma power change upon stimulus presentation and permutation test was applied for statistical comparisons. We also assessed in our participants visual orientation discrimination thresholds, which are thought to depend on excitability of inhibitory networks in the visual cortex.
Results
Although frequency of the oscillatory gamma response increased with increasing velocity of visual motion in both groups of participants, the velocity effect was reduced in a substantial proportion of children with ASD. The range of velocity-related gamma frequency modulation correlated inversely with the ability to discriminate oblique line orientation in the ASD group, while no such correlation has been observed in the group of typically developing participants.
Conclusions
Our findings suggest that abnormal velocity-related gamma frequency modulation in ASD may constitute a potential biomarker for reduced excitability of fast-spiking inhibitory neurons in a subset of children with ASD.
Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50–120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of excitation of the fast-spiking inhibitory basket cells recruited by increasing strength of excitatory input. Therefore, the experimental manipulations affecting gamma frequency may throw light on inhibitory networks dysfunction in ASD.
Methods
Here, we used magnetoencephalography (MEG) to investigate modulation of visual gamma oscillation frequency by speed of drifting annular gratings (1.2, 3.6, 6.0 °/s) in 21 boys with ASD and 26 typically developing boys aged 7–15 years. Multitaper method was used for analysis of spectra of gamma power change upon stimulus presentation and permutation test was applied for statistical comparisons. We also assessed in our participants visual orientation discrimination thresholds, which are thought to depend on excitability of inhibitory networks in the visual cortex.
Results
Although frequency of the oscillatory gamma response increased with increasing velocity of visual motion in both groups of participants, the velocity effect was reduced in a substantial proportion of children with ASD. The range of velocity-related gamma frequency modulation correlated inversely with the ability to discriminate oblique line orientation in the ASD group, while no such correlation has been observed in the group of typically developing participants.
Conclusions
Our findings suggest that abnormal velocity-related gamma frequency modulation in ASD may constitute a potential biomarker for reduced excitability of fast-spiking inhibitory neurons in a subset of children with ASD.
5.
Shtyrov, Yury Y.; Stroganova, Tatyana A. (2015). When ultrarapid is ultrarapid: on importance of temporal precision in neuroscience of language. Frontiers in Human Neuroscience, 9, 576. https://doi.org/10.3389/fnhum.2015.00576
@article{Shtyrov2015,
title = {When ultrarapid is ultrarapid: on importance of temporal precision in neuroscience of language},
author = {Yury Y. Shtyrov and Tatyana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.3389_fnhum.2015.00576.pdf},
doi = {10.3389/fnhum.2015.00576},
issn = {1662-5161},
year = {2015},
date = {2015-10-21},
urldate = {2015-10-21},
journal = {Frontiers in Human Neuroscience},
volume = {9},
pages = {576},
publisher = {Frontiers Media SA},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
4.
Orekhova, Elena V.; Butorina, Anna V.; Sysoeva, Olga V.; Prokofyev, Andrey O.; Nikolaeva, Anastasia Yu.; Stroganova, Tatiana A. (2015). Frequency of gamma oscillations in humans is modulated by velocity of visual motion. Journal of Neurophysiology, 114(1), 244-255. https://doi.org/10.1152/jn.00232.2015
@article{Orekhova2015,
title = {Frequency of gamma oscillations in humans is modulated by velocity of visual motion},
author = {Elena V. Orekhova and Anna V. Butorina and Olga V. Sysoeva and Andrey O. Prokofyev and Anastasia Yu. Nikolaeva and Tatiana A. Stroganova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1152_jn.00232.2015.pdf},
doi = {10.1152/jn.00232.2015},
issn = {1522-1598},
year = {2015},
date = {2015-07-00},
urldate = {2015-07-00},
journal = {Journal of Neurophysiology},
volume = {114},
number = {1},
pages = {244-255},
publisher = {American Physiological Society},
abstract = {Gamma oscillations are generated in networks of inhibitory fast-spiking (FS) parvalbumin-positive (PV) interneurons and pyramidal cells. In animals, gamma frequency is modulated by the velocity of visual motion; the effect of velocity has not been evaluated in humans. In this work, we have studied velocity-related modulations of gamma frequency in children using MEG/EEG. We also investigated whether such modulations predict the prominence of the "spatial suppression" effect (Tadin D, Lappin JS, Gilroy LA, Blake R. Nature 424: 312-315, 2003) that is thought to depend on cortical center-surround inhibitory mechanisms. MEG/EEG was recorded in 27 normal boys aged 8-15 yr while they watched high-contrast black-and-white annular gratings drifting with velocities of 1.2, 3.6, and 6.0°/s and performed a simple detection task. The spatial suppression effect was assessed in a separate psychophysical experiment. MEG gamma oscillation frequency increased while power decreased with increasing velocity of visual motion. In EEG, the effects were less reliable. The frequencies of the velocity-specific gamma peaks were 64.9, 74.8, and 87.1 Hz for the slow, medium, and fast motions, respectively. The frequency of the gamma response elicited during slow and medium velocity of visual motion decreased with subject age, whereas the range of gamma frequency modulation by velocity increased with age. The frequency modulation range predicted spatial suppression even after controlling for the effect of age. We suggest that the modulation of the MEG gamma frequency by velocity of visual motion reflects excitability of cortical inhibitory circuits and can be used to investigate their normal and pathological development in the human brain.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gamma oscillations are generated in networks of inhibitory fast-spiking (FS) parvalbumin-positive (PV) interneurons and pyramidal cells. In animals, gamma frequency is modulated by the velocity of visual motion; the effect of velocity has not been evaluated in humans. In this work, we have studied velocity-related modulations of gamma frequency in children using MEG/EEG. We also investigated whether such modulations predict the prominence of the "spatial suppression" effect (Tadin D, Lappin JS, Gilroy LA, Blake R. Nature 424: 312-315, 2003) that is thought to depend on cortical center-surround inhibitory mechanisms. MEG/EEG was recorded in 27 normal boys aged 8-15 yr while they watched high-contrast black-and-white annular gratings drifting with velocities of 1.2, 3.6, and 6.0°/s and performed a simple detection task. The spatial suppression effect was assessed in a separate psychophysical experiment. MEG gamma oscillation frequency increased while power decreased with increasing velocity of visual motion. In EEG, the effects were less reliable. The frequencies of the velocity-specific gamma peaks were 64.9, 74.8, and 87.1 Hz for the slow, medium, and fast motions, respectively. The frequency of the gamma response elicited during slow and medium velocity of visual motion decreased with subject age, whereas the range of gamma frequency modulation by velocity increased with age. The frequency modulation range predicted spatial suppression even after controlling for the effect of age. We suggest that the modulation of the MEG gamma frequency by velocity of visual motion reflects excitability of cortical inhibitory circuits and can be used to investigate their normal and pathological development in the human brain.