Ромеро Рейес Илакаи
Старший научный сотрудник
кандидат физ.-мат. наук
Публикации с аффилиацией МЭГ-центра
2026
2.
Fadeev, Kirill A.; Romero Reyes, Ilacai V.; Goiaeva, Dzerassa E.; Ovsiannikova, Tatiana M.; Prokofyev, Andrey O.; Rytikova, Anna M.; Novikov, Artem Y.; Stroganova, Tatiana A.; Orekhova, Elena V. (2026). Auditory P100m and Language Difficulties in Children With ASD: Effects of Vowel-Like Acoustic Structure. Autism Research, e70232. https://doi.org/10.1002/aur.70232
Abstract | PDF (preprint) | BibTeX
@article{Fadeev2026,
title = {Auditory P100m and Language Difficulties in Children With ASD: Effects of Vowel-Like Acoustic Structure},
author = {Kirill A. Fadeev and Romero Reyes, Ilacai V. and Dzerassa E. Goiaeva and Tatiana M. Ovsiannikova and Andrey O. Prokofyev and Anna M. Rytikova and Artem Y. Novikov and Tatiana A. Stroganova and Elena V. Orekhova},
url = {https://www.biorxiv.org/content/10.1101/2025.04.10.648101},
doi = {10.1002/aur.70232},
issn = {1939-3806},
year = {2026},
date = {2026-03-25},
urldate = {2026-03-25},
journal = {Autism Research},
volume = {e70232},
publisher = {Wiley},
abstract = {The P100/P100m component of auditory event-related potentials/fields is considered a potential biomarker of atypical arousal and language difficulties in children with ASD. When elicited by complex speech-like sounds with regular temporal or frequency structure, P100/P100m may be influenced by sustained negativity (SN), which can reduce its amplitude due to opposing current polarity and contribute to ASD-related differences. Using magnetoencephalography (MEG), we examined P100m responses to acoustic regularities in the left and right auditory cortices in 35 ASD and 39 TD boys (7–12 years). Stimuli included (1) temporally and spectrally regular sounds (periodic vowels), (2) temporally regular sounds (periodic non-vowels), (3) spectrally regular sounds (non-periodic vowels), as well as (4) non-regular control stimuli (non-periodic, non-vowels). P100m was estimated using distributed source localization. Both groups showed decreased P100m amplitude and latency with acoustic regularities, accompanied by proportional SN increases, suggesting P100m modulation primarily reflects early SN enhancement. No group differences were observed in P100m latency or amplitude, and their modulation by stimulus type was also normal in ASD, indicating spared processing of acoustic regularities in the P100m time range. However, P100m latencies variability was increased in boys with ASD, and their left P100m amplitudes to both non-regular and regular sounds were negatively associated with cumulative language and intellectual abilities. These findings suggest that while most children with ASD show typical P100m responses, individual variations in P100m amplitude may reflect neurodevelopmental differences in cortical maturation and/or sensory habituation processes that contribute to the heterogeneity of cognitive and language abilities in ASD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The P100/P100m component of auditory event-related potentials/fields is considered a potential biomarker of atypical arousal and language difficulties in children with ASD. When elicited by complex speech-like sounds with regular temporal or frequency structure, P100/P100m may be influenced by sustained negativity (SN), which can reduce its amplitude due to opposing current polarity and contribute to ASD-related differences. Using magnetoencephalography (MEG), we examined P100m responses to acoustic regularities in the left and right auditory cortices in 35 ASD and 39 TD boys (7–12 years). Stimuli included (1) temporally and spectrally regular sounds (periodic vowels), (2) temporally regular sounds (periodic non-vowels), (3) spectrally regular sounds (non-periodic vowels), as well as (4) non-regular control stimuli (non-periodic, non-vowels). P100m was estimated using distributed source localization. Both groups showed decreased P100m amplitude and latency with acoustic regularities, accompanied by proportional SN increases, suggesting P100m modulation primarily reflects early SN enhancement. No group differences were observed in P100m latency or amplitude, and their modulation by stimulus type was also normal in ASD, indicating spared processing of acoustic regularities in the P100m time range. However, P100m latencies variability was increased in boys with ASD, and their left P100m amplitudes to both non-regular and regular sounds were negatively associated with cumulative language and intellectual abilities. These findings suggest that while most children with ASD show typical P100m responses, individual variations in P100m amplitude may reflect neurodevelopmental differences in cortical maturation and/or sensory habituation processes that contribute to the heterogeneity of cognitive and language abilities in ASD.
2024
1.
Fadeev, Kirill A.; Romero Reyes, Ilacai V.; Goiaeva, Dzerassa E.; Obukhova, Tatiana S.; Ovsiannikova, Tatiana M.; Prokofyev, Andrey O.; Rytikova, Anna M.; Novikov, Artem Y.; Kozunov, Vladimir V.; Stroganova, Tatiana A.; Orekhova, Elena V. (2024). Attenuated processing of vowels in the left temporal cortex predicts speech-in-noise perception deficit in children with autism. Journal of Neurodevelopmental Disorders, 16(1). https://doi.org/10.1186/s11689-024-09585-2
@article{Fadeev2024,
title = {Attenuated processing of vowels in the left temporal cortex predicts speech-in-noise perception deficit in children with autism},
author = {Kirill A. Fadeev and Romero Reyes, Ilacai V. and Dzerassa E. Goiaeva and Tatiana S. Obukhova and Tatiana M. Ovsiannikova and Andrey O. Prokofyev and Anna M. Rytikova and Artem Y. Novikov and Vladimir V. Kozunov and Tatiana A. Stroganova and Elena V. Orekhova},
url = {https://megmoscow.ru/wp-content/uploads/pubs/10.1186_s11689-024-09585-2.pdf},
doi = {10.1186/s11689-024-09585-2},
year = {2024},
date = {2024-12-06},
urldate = {2024-12-06},
journal = {Journal of Neurodevelopmental Disorders},
volume = {16},
number = {1},
publisher = {Springer Science and Business Media LLC},
abstract = {Background
Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory “object”.
Methods
We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio.
Results
SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150—200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise.
Conclusions
These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background
Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory “object”.
Methods
We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio.
Results
SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150—200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise.
Conclusions
These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.
Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory “object”.
Methods
We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio.
Results
SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150—200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise.
Conclusions
These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.